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10/30/2025

Q&A: Does SIBO or SIFO (Candida/ Yeast) Cause Brain Fog? How to Treat Brain Fog?

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Key Discussions:
  1. Brain Fog and Its Causes:
    The video begins with a discussion by Dr. Siebecker on brain fog, exploring whether it is caused by Small Intestinal Bacterial Overgrowth (SIBO), Small Intestinal Fungal Overgrowth (SIFO), or a combination of both. The hosts explain that both conditions can contribute to brain fog, with SIFO potentially having a more pronounced effect.
  2. Symptomatic Relief for Brain Fog:
    The conversation shifts to potential remedies for brain fog. While there are no specific "anti-brain fog" medications, anti-inflammatories like NSAIDs, quercetin, bromelain, and fish oil are mentioned as helpful for some individuals. In addition, activated charcoal is highlighted as a top choice for absorbing metabolites that may contribute to brain fog.
  3. Personal Experiences and Recommendations:
    • Shivan Sarna shares her personal experiences with brain fog and the strategies that have helped her, such as using Advil PM and staying hydrated.
    • The importance of addressing the underlying conditions of SIBO and SIFO to alleviate brain fog is emphasized.
Takeaways:
  • Brain fog can be a complex symptom with multiple potential causes, including SIBO and SIFO.
  • While specific anti-brain fog treatments are not available, managing inflammation and addressing underlying gut health issues can provide relief.
  • Personal strategies like hydration, sleep, and certain supplements can be beneficial.
 Exclusive pricing on professional-grade supplements at Fullscript is mentioned.


Products mentioned:
- Anti-inflammatories (NSAIDS, fish oil, querceting, bromelain)
- LDN (low dose Naltrexone)
- Activated Charcoal: https://amzn.to/3S0zy7U (Amazon), https://us.fullscript.com/welcome/asiebecker (exclusive pricing at Fullscript)

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10/23/2025

Q&A: Stool Test for Methanogens and Does Zonulin Indicate Leaky Gut and SIBO?

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Key Discussions:
  1. Methane Overgrowth in Stool:
    The video begins with a discussion on the presence of methanogen levels in stool tests and whether this indicates methanogen overgrowth in the large intestine. The hosts express uncertainty about the sufficiency of evidence to classify it as IMO (Intestinal Methanogen Overgrowth) (Methane-SIBO).
  2. Expert Opinion:
    Dr. Allison Siebecker recalls Dr. Ali Rezaie suggesting that the presence of methane in stool could indeed indicate overgrowth.
  3. Zonulin, Leaky Gut and SIBO:
    The conversation shifts to Zonulin, a protein associated with leaky gut syndrome. It is clarified that high levels of Zonulin indicate leaky gut, but are not necessarily caused by SIBO (Small Intestinal Bacterial Overgrowth) or LIBO (Large Intestinal Bacterial Overgrowth). Zonulin and leaky gut do not necessarily indicate SIBO.
Takeaways:
  • Methane SIBO/ IMO: There is ongoing debate about the significance of methane presence in stool as an indicator of IMO (Intestinal Methanogen Overgrowth). Expert opinions vary, highlighting the need for more evidence.
  • Zonulin's Role: Zonulin is a marker for leaky gut but should not be used as a standalone indicator for bacterial overgrowth conditions like SIBO or LIBO.
  • Supplement Discount: Listeners in the US are informed about a discount on supplements, at Fullscript.
Products mentioned:
- Leaky gut supplements

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10/16/2025

Q&A: Is ibs-smart Test Enough to Know that Food Poisoning is the Root Cause for SIBO?

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Key Discussions

1. IBS-Smart Test Overview
The video begins with a discussion on the ibs-smart test, highlighting its utility in diagnosing underlying causes of SIBO (Small Intestinal Bacterial Overgrowth). The test is particularly useful for individuals who have experienced food poisoning, as it can indicate whether these incidents are contributing to their SIBO condition.

2. Case Study with Shivan Sarna
Shivan's experience is shared as a case study. She had a positive IBS-smart test, which confirmed food poisoning as a factor in her chronic SIBO. Additionally, Shivan's condition is complicated by Ehlers-Danlos syndrome and mold exposure, illustrating that multiple conditions can contribute to SIBO.

3. Importance of Prokinetics
The discussion emphasizes the role of prokinetics in managing SIBO, especially when the IBS smart test is positive because it indicates a slow or deficient migrating motor complex. Prokinetics are recommended for long-term use with chronic SIBO (as when Food Poisoning is the cause) to aid in symptom management. A positive IBS-Smart test helps improve patient compliance with prokinetics.

4. Current Research and Future Outlook
Dr. Pimentel's ongoing research is mentioned, with hopes for future advancements in curing SIBO caused by food poisoning. The discussion underscores the importance of understanding the physiological needs for effective treatment and management of SIBO.

Main Takeaways
- The ibs-smart test is a valuable diagnostic tool for identifying food poisoning as a cause of SIBO.
- Multiple underlying conditions can contribute to SIBO, necessitating a comprehensive approach to diagnosis and treatment.
- Prokinetics play a crucial role in managing symptoms and improving the quality of life for SIBO patients.
- Ongoing research is vital for developing future treatments and potentially curing SIBO.


Product mentioned:
- ibs-smart test 

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10/9/2025

Q&A: Should Laxatives Be Stopped Before a SIBO Test? How Long and Why?

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Key Discussions:

1. Challenges with Breath Tests 
The video begins with a discussion on the difficulties faced by individuals who are dependent on laxatives and the challenges they encounter when preparing for a breath test. The instructions typically require a waiting period of two weeks from diarrhea out of normal pattern, and abstaining from laxatives for four days prior to the test.

2. Expert Advice
Dr. Allison Siebecker provides advice on how to manage the preparation for a breath test. It is suggested that while four days without laxatives is the minimum requirement, five days would yield more accurate results. The importance of avoiding false negatives by adhering to these guidelines is emphasized.

 Takeaways:
Answer:
Yes, stop laxatives before SIBO testing x 5 days for best results.

Preparation for SIBO Tests
- Proper preparation is crucial for accurate medical test results. In the context of breath tests, stopping laxative use for 4-5 days is essential to avoid false negatives.

Supplement Discount

- Fullscript is a resource for obtaining supplements at exclusive pricing  


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10/2/2025

Q&A: What Helps Die Off During SIBO Treatment, and How Long Does it Last?

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In this video, we delve into the phenomenon of microbial die-off in SIBO, exploring its causes, symptoms, and management strategies. Our discussion provides insights into how die-off reactions occur and their impact on health, particularly focusing on yeast and bacteria.

Key Discussions:

1. What is Microbial Die-Off?
 Die-off occurs when microbes die, releasing toxins that can cause various symptoms. It is often associated with the treatment of infections and is more severe with yeast than bacteria.

2. Symptoms of Die-Off
Common symptoms include fatigue, flu-like symptoms, headaches, swollen glands, body aches, and muscle pain. These symptoms are similar to detox reactions and can vary in intensity.

3. Duration and Onset 
Symptoms typically begin on the second day of treatment and can last from one to three days. However, they can start as early as the first day after treatment begins and last longer.

4. Management and Treatment
To manage die-off symptoms, treatments such as anti-inflammatories, activated charcoal, and alkalinizing agents like Alka Seltzer Gold (no longer available) are recommended. These treatments are particularly noted in the Lyme disease community, where die-off is referred to as Herxheimer reaction.

5. Expert Opinions 
Dr. Mona Morstein's observations on die-off in SIBO patients are discussed, highlighting differing experiences among practitioners. This discussion also touches on the prevalence of die-off in SIBO (Small Intestinal Bacterial Overgrowth) patients.

Takeaways
- Understanding the symptoms and management of microbial die-off is crucial for those undergoing treatment for SIBO, IMO (methane SIBO) ISO (Hydrogen Sulfide SIBO) and SIFO (Candida, Yeast/Fungal overgrowth).
- Personalized treatment plans and awareness of potential reactions can help mitigate discomfort and improve outcomes.

Conclusion
This video provides insights into the complexities of SIBO die-off, equipping patients with knowledge to better manage the treatment process.


Products mentioned:
- Activated Charcoal: 
Amazon, or exclusive pricing at Fullscript 
- Alka Seltzer (no aspirin)

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This website is not intended to provide diagnosis, treatment or medical advice. Content is for informational purposes only. Always consult with a licensed healthcare professional regarding any medical or health related diagnosis or treatment options. Information on this website should not be considered as a substitute for advice from a licensed healthcare professional that knows your individual information. References to and statements made about specific products on this we website have not been evaluated by the U.S. Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent any disease.
  • HOME
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  • About SIBO
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    • SIBO Studies >
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