Q&A: Is LDN a Good Prokinetic for SIBO? Does LDN Help the MMC?

This video delves into the nuances of prokinetics and their effectiveness, particularly in the context of SIBO (Small Intestinal Bacterial Overgrowth).

• Individual Variability of Prokinetics: The discussion highlights that prokinetic treatments differ significantly in their effects from person to person. What works wonders for one individual may have little to no impact on another.
• Low Dose Naltrexone (LDN) as a Prokinetic:
  • While not technically classified as a prokinetic, LDN has demonstrated prokinetic effects in studies, largely due to its influence on opioids in the body.
  • For some, LDN can be "phenomenal," leading to no relapses and offering additional benefits such as anti-inflammatory properties, immune system balance, and mood improvement.
  • However, for others, LDN may not be a strong enough prokinetic.
• LDN and Severe SIBO:
  • LDN is often not sufficient for individuals with severe or recalcitrant SIBO, especially when underlying conditions like Ehlers-Danlos syndrome or scleroderma are present.
  • In such cases, a combined approach using LDN alongside another prokinetic, especially pharmaceutical, is recommended.
• Pharmaceutical Prokinetic Options: When LDN is insufficient, stronger interventions are necessary:
  • Prucalopride (marketed as Motegrity in the US).
  • Low-dose Erythromycin
• Conclusion: The effectiveness of any treatment, especially prokinetics, requires individual assessment. Trying different options is key to finding what works best.

Products Mentioned:
Prokinetics (pharmaceutical):
~ LDN (low dose Naltrexone - low dose has very different effects vs regular dose)
~ Prucalopride (Motegrity)
~ Low Dose Erythromycin
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Herbal Prokinetics list: (Fullscript here)