Q&A: Which Prokinetics Help SIBO Constipation and What Dose?

Key Discussions on Gastrointestinal Prokinetic Agents
This video delves into the mechanisms and effectiveness of several substances known to influence gastrointestinal motility, particularly focusing on their prokinetic effects.

• Prucalopride: The discussion confirms that Prucalopride can be effective for constipation at higher doses. It is noted for its potential to affect the whole gastrointestinal tract depending on dose, and has been specifically studied for constipation.
• Ginger: Ginger is highlighted as being primarily associated with effects on the stomach and upper small intestine.
• Erythromycin: At higher, antibiotic dosing strengths, erythromycin is understood to affect the large intestine. Whereas at lower doses, it affects the small intestine MMC. This is similar to prucalopride. 
• Comparative Study Findings: An interesting point raised is a study comparing different doses of Prucalopride. In this study, 2 milligrams of Prucalopride was found to be more effective than 4 milligrams for treating constipation, a surprising but significant finding.
  
  

Products Mentioned:
- Prucalopride (Motegrity) Rx: 2-4mg helps constipation (0.5-1mg helps SIBO relapse prevention)
- Erythromycin Rx
Ginger Prokinetics:
- Various options (15% off at Fullscript)
- Motility Activator: https://amzn.to/3WKWs6o (Amazon)
- GI Motility Complex: https://amzn.to/3htdu93 (Amazon)
- Gut Motility: https://amzn.to/3twZ8r3 (Amazon)
- SIBO-MMC: https://amzn.to/3Tnu1bL (Amazon)

Links are affiliate.