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3/26/2026

Q&A: Why Do SIBO Treatments Worsen My Symptoms? Is it MCAS/Histamine Intolerance?

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This video addresses challenges encountered with SIBO treatment protocols and explores potential underlying issues and alternative approaches.

A Patient's SIBO Treatment Experience
  • A patient has undergone 4 treatment protocols, including elemental diet, antibiotics and herbs.
  • Each treatment cycle has unfortunately worsened SIBO and food sensitivities.
  • She is experiencing severe symptoms such as brain fog, making work impossible, joint pain, and insomnia.
  • The patient is seeking to understand if she's missing a root cause or what other strategies she could try.
Addressing Difficult SIBO Cases
  • Dr. Allison Siebecker notes that more information is needed for a proper analysis, including test results (before and after) and details of past treatments.
  • However, for individuals experiencing severe symptoms from SIBO treatments, common considerations include:
    • Yeast overgrowth (which can cause worse die-off vs bactaria)
    • Histamine sensitivity (MCAS or histamine intolerance)
    • Mold exposure
  • These conditions can complicate SIBO treatment due to adverse reactions to the treatments.
A Success Story with Cromolyn for MCAS
  • A participant shares her positive experience starting cromolyn.
  • She takes 200 milligrams orally three times a day for MCAS.
  • Within 20 days, all her symptoms have reportedly disappeared, which is highlighted as a significant positive outcome.
Alternative Approach for Histamine Intolerance (MCAS)
  • A colleague who treats many MCAS, Lyme, and mold cases, utilizes an interesting protocol.
  • This approach involves using traditional over-the-counter antihistamines.
  • The doses are adjusted to be lower, such as cutting pills in half or using child dosing, taken three times a day.
  • This method has shown excellent results for her patients.
Key Takeaway
  • Mast Cell Activation Syndrome (MCAS) is frequently an underlying factor for individuals dealing with difficult-to-treat SIBO.
Product Mentioned:
~Cromolyn Sodium prescription Rx for histamine intolerance/MCAS
~standard antihistamines  

For more on treating Tough SIBO see: Tough SIBO Masterclass by Dr. Siebecker

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  • HOME
    • HOME
  • About SIBO
    • WHAT IS SIBO?
    • SIBO Symptoms
    • Associated Diseases
    • What Causes SIBO?
    • SIBO & IBS
  • SIBO TESTS
    • SIBO Tests
  • TREATMENT
    • How To Treat SIBO
    • Symptom Relief
    • What to Avoid
    • Antibiotics
    • Herbal Antibiotics
    • Elemental Diet
    • SIBO Diet
    • Prevention of Relapse
    • Probiotics
  • SIBO COURSES
    • SIBO Courses
  • SIBO SUPPORT
    • SIBO Support
  • RESOURCES
    • Discounts
    • BLOG
    • SIBO Podcasts
    • SIBO Studies >
      • SIBO Studies: 2026
      • SIBO Studies: 2025
      • SIBO Studies: 2024
      • SIBO Studies: 2023
      • SIBO Studies: 2022
      • SIBO Studies: 2021
      • SIBO Studies: 2020
      • SIBO Studies: 2019
      • SIBO Studies: 2018
      • SIBO Studies: 2017
      • SIBO Studies: 2016
      • SIBO Studies: 2015
      • SIBO Studies: 2014
      • SIBO Studies: 2013
      • SIBO Studies: 2012
      • SIBO Studies: 2011
      • SIBO Studies: 2009
      • SIBO Studies: 1990's
      • SIBO Studies: 1980's
    • SIBO Books
    • SIBO Recipes & Cookbooks
    • MMC Videos
    • Test Directory
    • Finding a SIBO Doctor
  • CONTACT
    • Contact
    • About Dr. Siebecker
    • Online Consultations
  • Log in button LOGIN