SIBO Associated Conditions

SIBO is associated with a very large list of other disorders. There are three ways other conditions can relate to SIBO: 1) they can be a cause of SIBO, 2) SIBO can cause them, or 3) they can co-exist with SIBO. If you or one of your patients has one of the following conditions, testing for SIBO may be merited. [Studies are linked in brackets]. 

Alphabetical listing of SIBO associated conditions, with study links:

  • Multiple conditions [1]
  • Acne Vulgaris [1]
  • Acromegaly [1]
  • Acute Gastroenteritis (Food Poisoning) [1], [2], [3], [4], [5], [6], [7]
  • Age: 
    • Elderly [1], [2], [3], [4]
    • Children (see Pediatric)
  • Alcohol Consumption (moderate intake) [1], [2]
  • Alcoholic Liver Disease (see Liver below)
  • Alzheimer's [1],[2],[3]
  • Anorexia [1]
  • Anemia (see also Pernicious Anemia) [1], [2]
  • Amyloidosis [1]
  • Anxiety [1], [2]
  • Asthma [1]
  • Atherosclerosis (Subclinical) [1]
  • Atrophic Gastritis [1], [2]
  • Autism [1], [2], [3]
  • Autoimmune SIBO (see Acute Gastroenteritis)
  • Behçet's disease (intestinal) [1]
  • Bile Acid Dysmetabolism [1], [3]
  • Bloating (Chronic Functional Bloating) [1]
  • Bowel-associated dermatosis-arthritis syndrome [1], [2]
  • Burn Injury [1]
  • Brain Fog [1], [2], [3], [4]
  • C. difficele infection [1]
  • Cancer [1], [2], [3], [4], [5], [6], [7], [8]
  • Candida overgrowth (see SIFO)
  • Celiac Disease (see also Tropical Sprue) [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
  • Children (see Pediatric) 
  • Cholangitis [2], [3]
  • Cholestasis (Progressive Familial Intrahepatic) [1]
  • Chronic diarrhea [1], [2]
  • Chronic Fatigue Syndrome [1], [2], [3], [4], [5]
  • Chronic Intestinal Pseudo-Obstruction [1], [2], [3], [4], [5], [6], [7], [8]
  • Chronic Lymphocytic Leukemia [1]
  • Cirrhosis (see also Liver, Hepatic, MASH) [1], {2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]
  • Common Variable Immunodeficiency (CVID) [1], [2], [3]
  • Congestive Heart Failure (see Heart Failure) 
  • Congenital sucrase-isomaltase deficiency [1], [2]
  • COPD (Chronic Obstructive Pulmonary Disease) [1]
  • Coronary Artery Disease [1], [2], [3]
  • Covid-19  [1], [2]
  • Critically Ill ICU patients [1]
  • Crohn's Disease (see IBD)
  • Cronkhite-Canada Syndrome [1]
  • Cystic Fibrosis [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
  • D-Lactic Acidosis [1], [2], [3], [4]
  • Deep Vein Thrombosis [1], [2], [3]
  • Dental/Oral Health [1]
  • Depression [1], [2], [3]
  • Diabetes [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
    • Diabetes Type I [1]
    • Gestational Diabetes [1]
  • Diverticular Disease [1], [2], [3], [4], [5], [6]
  • Drugs [1], 
  • Dyspepsia [1], [2], [3], [4], [5]
  • Ehlers-Danlos Syndrome [1], [2], [3], [4], [5], [6]
  • Elderly [1], [2], [3], [4], [5]
  • Endometriosis [1], [2]
  • Environmental Enteric Dysfunction [1], [2], [3], [4], [5]
  • Erosive Esophagitis [1]
  • Familial Mediterranean Fever [1]
  • Fatty Liver Disease (see MASH)
  • Fecal Microbiota Transplantation (FMT) [1]
  • Fibromyalgia [1], [2], [3]
  • Food Poisoning (see Acute Gastroenteritis)
  • Functional Dyspepsia [1], [2}, [3], [4], [5], [6]
  • Fructose Malabsorption [1], [2], [3]
  • Gallbladder Disease [1] 
  • Gallbladder Polyps [1]
  • Gallstones [1], [2], [3], [4]
  • Gastric Bypass [1], [2], [3], [4], [5], [6], [7], [8]
  • Gastroparesis [1], [2], [3], [4], [5], [6], [7], [8], [9] review
  • GERD (Gastroesophageal Reflux Disease) [1], [2], [3], [4], [5], [6], [7], [8], [9]
    • GERD & PPI's [1], [2], [3], 
  • GLP-1 [1], [2]
  • Halitosis [1], [2], [3]
  • Hashimoto's (see Hypothyroid)
  • Heart Failure [1], [2], [3], [4], [5], [6]
  • HIV [1], [2], [3], [4]
  • Hepatocellular Carcinoma [1]
  • Hepatic Encephalopathy [1], [2], [3], [4], [5], [6]
  • Hepatic Injury (see also Cirrhosis, Liver, MASH) [1]
  • Hypertension (High Blood Pressure) [1]
  • Hypothyroidism [1], [2]
  • H pylori Infection [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
  • Hypochlorhydria (low stomach acid) [1], [2], [3]
  • Hypothyroid/Hashimoto's Thyroiditis [1], [2], [3], [4], [5], [6], [7], [8], [9], [10]
  • Ileocecal Valve
    • Resection [1], [2], [3], [4]
    • Insufficiency (Ileocical valve syndrome) [1], [2], [3]
  • Inflammatory Bowel Disease (IBD) [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
    • Crohn's [1], [2], [3], [4], [5], [6], [7], [8], [9]
    • Ulcerative Colitis [1], [2], [3], [4], [5], [6]
  • Irritable Bowel Syndrome (IBS) [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21]
  • Immune Deficiency/Suppression [1]
  • Interstitial Cystitis [1]
  • Intestinal ischemia/reperfusion injury [1]
  • Intestinal Failure [1], {2}, [3], [4], [5], [6]
  • Kidney Stones [1]
  • Klein-Levin Syndrome [1]
  • Lactose Intolerance [1], [2], [3], [4], [5], [6], [7], [8], [9], [10]
  • Large Intestine Dysbiosis [1]
  • Leaky Gut [1] (Increased Intestinal Permeability), [2], [3], [4]
  • Lipomatosis [1]
  • Liver Disease (see also: Cirrhosis, Hepatic and MASH)  [1], [2], [3],[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
    • Alcoholic Liver Disease [1], [2]
    • Liver inflammation [1], [2], [3], [4], [5]
    • Liver failure [1]
  • Long Covid [1]
  • Lyme [1/pdf of 1], [2] 
  • Malabsorption Syndrome [1], [2], [3], [4], [5], [6]
  • Malnutrition [1]
  • Marfan Syndrome [1], [2]
  • MASH/MAFLD (Metabolic dysfunction-associated steatohepatitis) [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17, [18], [19], [20], [21], [22], [23], [24], [25]
  • Mast Cell Activation Syndrome (MCAS) [1], [2], [3], [4]
  • Medications
    • Antibiotics [1]
    • Anesthesia [1], [2]
    • Narcotics/Opioids [1]
    • NSAIDS [1]
    • Proton Pump Inhibitors (PPI) [1], [2], [3], [4], [5], [6], [7], [8]
    • Steroids [1], [2]
    • Total Parenteral Nutrition [1]
  • ​Metabolic Syndrome [1], [2]
  • Mood Disorders ​[1]
  • Multiple Sclerosis (MS) [1]
  • Muscular Dystrophy [1] 
  • Myelomeningocele (spina bifida) [1] 
  • NASH/NAFLD (see MASH) 
  • Obesity [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
  • Osteoporosis/Osteopenia [1], [2]
  • Pancreatitis [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
  • Pancreatic Insufficiency [1]
  • Pancreatic Carcinoma [1]
  • Pancreatic Resection [1] 
  • Parasites [1], [2], [3], [4], [5], [6]
  • Parkinson's disease [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37]
  • Pediatric [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23],[24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]. [66], [67], [68], [69], [70], [71], [72], [73], [74]
    • Pediatric Intestinal Failure [1], [2], [3]
  • Pernicious Anemia [1], [2]
  • Pneumatosis Cystoides (Secondary) [1]
  • Polyderma Faciale [1]
  • POTS (Postural Orthostatic Tachycardia Syndrome) [1], [2], [3]
  • Post-Infectious IBS (see Acute Gastroenteritis) 
  • Pouchitis [1], [2]
  • PPI [1], [2], [3]
  • Prostatitis (chronic) [1] 
  • Psoriasis [1], [2], [3]
  • Radiation Enteropathy [1]
  • Restless Leg Syndrome [1], [2], [3], [4], [5]
  • Rheumatoid Arthritis [1], [2]
  • Rosacea [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
  • Scleroderma (See Systemic Sclerosis) 
  • Sexual Dysfunction [1]
  • Short Bowel Syndrome [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26]
  • SIFO (Small Intestinal Fungal Overgrowth) [1], [2], [3], [4], [5], [6], [7]
  • Sleep Apnea [1]
  • Spinal Cord Injury [1], [2], [3], [4]
  • Spondylarthropathy [1]
  • Stroke [1]
  • Superior Mesenteric Artery Syndrome [1], [2]
  • Surgery:
    • Abdominal [1]
    • Appendectomy [1]
    • Bariatric (see Gastric Bypass above) [1], [2], [3], [4], [5], [6], [7]
    • Blind Loop [1]
    • Colectomy [1], [2]
    • Cholecystectomy [1], [2], [3]
    • Gastric Bypass (see Gastric Bypass above)
    • Gastrectomy [1], [2], [3]
    • Hysterectomy [1]
    • Ileoecal Valve Resection (see Ileoecal Valve: Resection above)
    • Post Colon Cancer [1], [2], [3]
    • Post Esophageal and Gastric Cancer [1] 
  • Systemic Sclerosis [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
  • Thyroid [1], [2]
  • Traumatic Brain Injury [1]​, [2]
  • Traveler's Diarrhea (see Acute Gastroenteritis)               
  • Tropical Sprue [1], [2], [3], [4], [5]
  • Ulcer: Duodenal [1]
  • Ulcerative Colitis (see IBD) 
  • Visceral Fat [1]
  • Vitamin K-responsive coagulopathy [1]
  • Vitamin Deficiency
    • Vitamin B12 deficiency [1]
    • Vitamin K2 deficiency [1], [2]
    • Vitamin A, E & K deficiency (fat soluble) [1] ​
  • Whipple's Disease [1]
  • Yeast Overgrowth (see SIFO)

More Resources: Associated Conditions playlist on my You Tube  

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