SIBO Overview
- Other Diseases of the Small Intestine and Colon. DOI 10.1016/B978-0-323-67293-1.00049-9
- Small Intestinal Bacterial Overgrowth PMID: 34024452
- Small Intestinal Bacterial Overgrowth. PMID: 31536241
SIBO Causes/Risk Factors
Diseases
- [Diverticula in the gastrointestinal tract]. PMID: 33560449
- Modified Antimesenteric Tapering Enteroplasty: An Alternative Technique for the Treatment of Dysfunctional Anastomosis in Patients With Short Bowel. PMID: 34397564
- NeoCHIRP: A model for intestinal rehabilitation in the neonatal intensive care unit. PMID: 34270133
- Laparoscopic Management of Congenital Intestinal Obstruction: Duodenal Atresia and Small Bowel Atresia. PMID: 34357817
- Structural and quantitative alterations of gut microbiota in experimental small bowel obstruction. PMID: 34347831
SIBO Pathophysiology
- [The role of intraepithelial lymphocytes in pathogenesis of small intestinal bacterial overgrowth syndrome]. PMID: 33713088
- A LOWER RISK FOR VITAMIN B12 DEFICIENCY DISTINGUISHES SMALL INTESTINAL BACTERIAL OVERGROWTH (SIBO) CAUSED BY METHANE-PRODUCING ARCHAEA FROM SIBO CAUSED BY HYDROGEN-PRODUCING BACTERIA doi: 10.1016/S0016-5085(21)01603-6
- Serotonin Pathway of Tryptophan Metabolism in Small Intestinal Bacterial Overgrowth-A Pilot Study with Patients Diagnosed with Lactulose Hydrogen Breath Test and Treated with Rifaximin PMID: 34065903
- THE FIRST SYSTEMS BIOLOGY APPROACH TO THE MICROBIOME OF SIBO BY HIGH-LEVEL CO-OCCURRENCE COMMUNITY NETWORK ANALYSES IDENTIFIES TWO DISTINCT PROTEOBACTERIA-RELATED CLUSTERS DOI:10.1016/S0016-5085(21)01386-X
- TRANSPLANTATION OF FUSOBACTERIUM VARIUM IN VIVO RESULTS IN AN INCREASE OF PRO-INFLAMMATORY CYTOKINES AND STOOL WET WEIGHT DOI:10.1016/S0016-5085(21)02071-0
- Summary: Dr. Pimentel and team have linked hydrogen sulfide SIBO to fusobacterium varium bacteria, in this animal study. On twitter, Dr. Pimentel commented: “Could this be the culprit in IBS contributing to diarrhea and a positive H2S on new 4 gas breath test? Stay tuned.”
- Mucosa-Associated Microbial Profile Is Altered in Small Intestinal Bacterial Overgrowth PMID: 34421869
SIBO Associated Conditions
Children
- Management of small intestinal bacterial overgrowth by paediatric gastroenterologists in Spain. PMID: 33371710
- Percutaneous endoscopic gastrojejunostomy in pediatric intestinal pseudo-obstruction PMID: 33601120
- Management of small intestinal bacterial overgrowth by pediatric gastroenterologists in Spain. PMID: 33371710
- An ESPGHAN Position Paper on the Use of Bre ath Testing in Paediatric Gastroenterology. PMID: 34292218
- Laparoscopic Management of Congenital Intestinal Obstruction: Duodenal Atresia and Small Bowel Atresia. PMID: 34357817
- NeoCHIRP: A model for intestinal rehabilitation in the neonatal intensive care unit. PMID: 34270133
- What Are the Pearls and Pitfalls of the Dietary Management for Chronic Diarrhoea? PMID: 33919083
- Development of a Score to Predict Positive Colonic Histology in Chronic Diarrhea Assessed in Open-access Colonoscopy. PMID: 32833700
- Application of methane and hydrogen-based breath test in the study of gestational diabetes mellitus and intestinal microbes PMID: 33932493
- [Diverticula in the gastrointestinal tract]. PMID: 33560449
- Small Intestinal Bacterial Overgrowth in Functional Dyspepsia: A Systematic Review and Meta-Analysis. PMID: 33734110
- Changes in oral flora of patients with functional dyspepsia PMID: 33850203
- Concomitant Irritable Bowel Syndrome Does Not Influence the Response to Antimicrobial Therapy in Patients with Functional Dyspepsia PMID: 34392491
- Fructose malabsorption: Causes, diagnosis and treatment PMID: 33818329
- The prevalence of intestinal dysbiosis in patients referred for antireflux surgery. PMID: 33475845
- PREVALENCE AND ASSOCIATION OF VITAMIN B12 DEFICIENCY AND SMALL INTESTINAL BACTERIAL OVERGROWTH IN PATIENTS TAKING PROTON PUMP INHIBITORS doi.org/10.1016/S0016-5085(21)02073-4
- Association of Small Intestinal Bacterial Overgrowth With Heart Failure and Its Prediction for Short-Term Outcomes. PMID: 33728933
- Bacterial metabolites trimethylamine N-oxide and butyrate as surrogates of small intestinal bacterial overgrowth in patients with a recent decompensated heart failure PMID: 33731747
- Correlation between small intestinal bacterial overgrowth and irritable bowel syndrome and the prognosis of treatment PMID: 33849121
- RIFAXIMIN IMPROVES BOTH ABDOMINAL PAIN AND BLOATING IN PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH DIARRHEA: A COMPOSITE ENDPOINT ANALYSIS OF TWO PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED TRIALS doi.org/10.1016/S0016-5085(21)01398-6
- RIFAXIMIN SIGNIFICANTLY IMPROVES BOWEL MOVEMENT URGENCY IN PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH DIARRHEA: A POOLED ANALYSIS OF THREE PHASE 3 TRIALS doi.org/10.1016/S0016-5085(21)01399-8
- Emerging Role of the Gut Microbiome in Irritable Bowel Syndrome PMID: 34304786
- Uncovering the pathophysiology of irritable bowel syndrome by exploring the gut-brain axis: a narrative review PMID: 34430628
- A Comprehensive Review of Transaminitis and Irritable Bowel Syndrome PMID: 34322359
- Small Intestinal Bacterial Overgrowth In Various Functional Gastrointestinal Disorders: A Case-Control Study PMID: 34417923
- Small intestinal bacterial overgrowth and evaluation of intestinal barrier function in patients with ulcerative colitis PMID: 34306403
- Small intestinal bacterial overgrowth in patients with inflammatory bowel disease: A case-control study PMID: 34390471
- [Mechanism of gut-microbiota-liver axis in the pathogenesis of intestinal failure-associated liver disease]. PMID: 33461259
- [Chronic intestinal failure] PMID: 34264370
- Small intestinal bacterial overgrowth and nonalcoholic fatty liver disease diagnosed by transient elastography and liver biopsy. PMID: 33406286
- Small intestinal bacterial overgrowth and orocecal transit time in patients of nonalcoholic fatty liver disease PMID: 33867442
- Leaky Gut and Gut-Liver Axis in Liver Cirrhosis: Clinical Studies Update. PMID: 33071239
- Assessment of small intestinal bacterial overgrowth in chronic pancreatitis patients using jejunal aspirate culture and glucose hydrogen breath test. PMID: 33730978
- Intestinal bacterial overgrowth in the early stage of severe acute pancreatitis is associated with acute respiratory distress syndrome PMID: 33958849
- Response to Comment on "Association of Intestinal Disorders with Parkinson's Disease and Alzheimer's Disease: A Systematic Review and Meta-Analysis". PMID: 33503369
- Association of small intestinal bacterial overgrowth with Parkinson's disease: a systematic review and meta-analysis PMID: 33863370
- Evaluation of fecal microbiota transplantation in Parkinson's disease patients with constipation PMID: 33985520
- Rosacea, Germs, and Bowels: A Review on Gastrointestinal Comorbidities and Gut-Skin Axis of Rosacea. PMID: 33507499
- Dysbiotic gut microbiota in inflammatory rosacea patients: another clue towards the existence of a brain-gut-skin axis PMID: 33913159
- Laparoscopic Management of Congenital Intestinal Obstruction: Duodenal Atresia and Small Bowel Atresia. PMID: 34357817
- Structural and quantitative alterations of gut microbiota in experimental small bowel obstruction. PMID: 34347831
- Small intestinal bacterial overgrowth in spinal cord injury patients. PMID: 33640466
- Small intestinal bacterial overgrowth in spinal cord injury patients DOI: 10.1016/j.gastre.2021.09.005
- High prevalence of small intestinal bacterial overgrowth (SIBO) in spondylarthropathy. PMID: 33427609
SIBO Testing
- Every Breath Test You Take: Practical Advice on Breath Testing Used to Detect Small Intestinal Bacterial Overgrowth. PMID: 33428040
- Serum Gastrin Predicts Hydrogen-Producing Small Intestinal Bacterial Overgrowth in Patients With Abdominal Surgery: A Prospective Study. PMID: 33369565
- How the North American Consensus Protocol Affects the Performance of Glucose Breath Testing for Bacterial Overgrowth Versus a Traditional Method. PMID: 33560649
- EXHALED HYDROGEN SULFIDE IS INCREASED IN PATIENTS WITH DIARRHEA- RESULTS OF A NOVEL COLLECTION AND BREATH TESTING DEVICE DOI:10.1016/S0016-5085(21)01391-3
- BREATH HYDROGEN RESPONSES MEASURED BY A NOVEL PORTABLE HYDROGEN BREATH ANALYZER AND SMART PHONE APP USED AT HOME CAN DISTINGUISH NORMAL SUBJECTS FROM PATIENTS WITH SUSPECTED SIBO. Sa384
- Serotonin Pathway of Tryptophan Metabolism in Small Intestinal Bacterial Overgrowth-A Pilot Study with Patients Diagnosed with Lactulose Hydrogen Breath Test and Treated with Rifaximin PMID: 34065903
- Bacterial Overgrowth of the Small Intestine Breath Test doi.org/10.1016/B978-0-323-43044-9.00009-1
- Small-bowel aspiration during upper esophagogastroduodenoscopy: Rao technique. PMID: 33898888
- How the North American Consensus Protocol Affects the Performance of Glucose Breath Testing for Bacterial Overgrowth Versus a Traditional Method. PMID: 33982948
- Pattern of methane levels with lactulose breath testing; can we shorten the test duration? PMID: 34263076
- Characteristics of oxygen concentration and the role of correction factor in real-time GI breath test PMID: 34168044
- A Promising Approach: Artificial Intelligence Applied to Small Intestinal Bacterial Overgrowth (SIBO) Diagnosis Using Cluster Analysis PMID: 34441379
- An ESPGHAN Position Paper on the Use of Breath Testing in Paediatric Gastroenterology. PMID: 34292218
- European guideline on indications, performance, and clinical impact of hydrogen and methane breath tests in adult and pediatric patients: European Association for Gastroenterology, Endoscopy and Nutrition, European Society of Neurogastroenterology and Motility, and European Society for Paediatric Gastroenterology Hepatology and Nutrition consensus. PMID: 34431620
SIBO Methane
Hydrogen Sulfide SIBO
- TRANSPLANTATION OF FUSOBACTERIUM VARIUM IN VIVO RESULTS IN AN INCREASE OF PRO-INFLAMMATORY CYTOKINES AND STOOL WET WEIGHT DOI:10.1016/S0016-5085(21)02071-0
- Summary: Dr. Pimentel and team have linked hydrogen sulfide SIBO to fusobacterium varium bacteria, in this animal study. On twitter, Dr. Pimentel commented: “Could this be the culprit in IBS contributing to diarrhea and a positive H2S on new 4 gas breath test? Stay tuned.”
SIBO Treatment
- Management of small intestinal bacterial overgrowth by paediatric gastroenterologists in Spain. PMID: 33371710
- Efficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study. PMID: 33478482
- Exploring Mucin as Adjunct to Phage Therapy. PMID: 33670927 NEW
- Effects of Bovine Colostrum with or without Egg on In Vitro Bacterial-Induced Intestinal Damage with Relevance for SIBO and Infectious Diarrhea PMID: 3380994
- Summary: This study shows Colostrum, with its immunoglobulins, epithelial growth factors and more, helps protect against leaky gut and small intestine damage in SIBO. Brands of Colostrum that I have used and like, include Symbiotics and NuMedica. Note that colostrum is a dairy product. Non-dairy immunoglobulins are available as serum bovine immunoglobulins: see my SIBO Symptomatic Relief Handout under Diarrhea, for products.
- Management of small intestinal bacterial overgrowth by pediatric gastroenterologists in Spain PMID: 33371710
- Antibiotic treatment for small intestinal bacterial overgrowth: Is a cocktail better than a single? PMID: 33951351
- The effectiveness of rotating versus single course antibiotics for small intestinal bacterial overgrowth PMID: 34241973
- Rifaximin PMID: 32966000
- Bifidobacterium longum W11: Uniqueness and individual or combined clinical use in association with rifaximin PMID: 33745570
- Serotonin Pathway of Tryptophan Metabolism in Small Intestinal Bacterial Overgrowth-A Pilot Study with Patients Diagnosed with Lactulose Hydrogen Breath Test and Treated with Rifaximin PMID: 34065903
- Homemade Elemental Diet to Treat Intestinal Methanogen Overgrowth: A Case Report.(see "Research Updates" above this section)
- Impact of Diet on Symptoms of the Irritable Bowel Syndrome. PMID: 33572262
- Treatment efficacy of a low FODMAP diet compared to a low lactose diet in IBS patients: A randomized, cross-over designed study. PMID: 33183577
- Low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol diet in patients with diarrhea-predominant irritable bowel syndrome: A prospective, randomized trial. PMID: 33464683
- Methane and fatty acid metabolism pathways are predictive of Low-FODMAP diet efficacy for patients with irritable bowel syndrome. PMID: 33504454
- Habitual FODMAP Intake in Relation to Symptom Severity and Pattern in Patients with Irritable Bowel Syndrome. PMID: 33374779
- Irritable Bowel Syndrome: Food as a Friend or Foe? PMID: 33518164
- Fundamental study on changes in the FODMAP profile of cereals, pseudo-cereals, and pulses during the malting process. DOI 10.1016/j.foodchem.2020.128549
- What is the optimal FODMAP threshold in IBS? PMID: 33624857
- Dietary interventions and irritable bowel syndrome - what really works? PMID: 33332914
- Editorial: defining a microbial signature to predict non-response to a FODMAP diet-a step closer or is it? PMID: 33566410
- Editorial: defining a microbial signature to predict non-response to a low FODMAP diet-a step closer or is it? Authors' reply. PMID: 33566399
- Efficacy of a low-FODMAP diet in adult irritable bowel syndrome: a systematic review and meta-analysis. PMID: 33585949
- The role of diet in the pathophysiology and management of irritable bowel syndrome. PMID: 33666892
- Long-term symptom severity in people with irritable bowel syndrome following dietetic treatment in primary care: A service evaluation. PMID: 33761153
- Reducing FODMAPs and improving bread quality using type II sourdough with selected starter cultures. PMID: 33653200
- Low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols diet compared with traditional dietary advice for diarrhea-predominant irritable bowel syndrome: a parallel-group, randomized controlled trial with analysis of clinical and microbiological factors associated with patient outcomes. PMID: 33740048
- FODMAP Fingerprinting of Bakery Products and Sourdoughs: Quantitative Assessment and Content Reduction through Fermentation PMID: 33921672
- The low FODMAP diet for IBS; A multicentre UK study assessing long term follow up PMID: 34083153
- Low FODMAP (fermentable oligo-, di-, monosaccharides, and polyol) diet goes global PMID: 33851195
- Diarrhea Predominant-Irritable Bowel Syndrome (IBS-D): Effects of Different Nutritional Patterns on Intestinal Dysbiosis and Symptoms PMID: 33946961
- Low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet is associated with increased risk of uninvestigated chronic dyspepsia and its symptoms in adults PMID: 33971708
- The Relationship between Low Serum Vitamin D Levels and Altered Intestinal Barrier Function in Patients with IBS Diarrhoea Undergoing a Long-Term Low-FODMAP Diet: Novel Observations from a Clinical Trial PMID: 33801020
- Gluten and FODMAPs Relationship with Mental Disorders: Systematic Review PMID: 34072914
- Intestinal microbiota fingerprint in subjects with irritable bowel syndrome responders to a low FODMAP diet PMID: 33877245
- Better response to low FODMAP diet in DGBI patients with pronounced hydrogen response to a nutrient challenge test PMID: 34107550
- Epigastric symptom response to low FODMAP dietary advice compared with standard dietetic advice in individuals with functional dyspepsia PMID: 33844408
- High-Fat Foods and FODMAPs Containing Gluten Foods Primarily Contribute to Symptoms of Irritable Bowel Syndrome in Korean Adults PMID: 33920966
- Physicochemical and nutritional properties of high protein emulsion-type lupin-based model milk alternatives: effect of protein source and homogenization pressure PMID: 33792053
- Characteristics and properties of fibres suitable for a low FODMAP diet- an overview doi.org/10.1016/j.tifs.2021.04.023
- Low Fodmap Diet & Prebiotic β-Galactooligosaccharides Improve Irritable Bowel Syndrome with no Impact on α-Diversity and Response to Low Fodmap Diet is Predicted by Urine and Fecal Metabolites: A Randomised Controlled Trial doi.org/10.1016/S0016-5085(18)32410-7
- LOW FODMAP DIET ADHERENCE IS HIGH AND POSITIVELY IMPACTS NUTRITIONAL INTAKE AND DIET QUALITY IN CHILDREN WITH IRRITABLE BOWEL SYNDROME (IBS) doi.org/10.1016/S0016-5085(21)02515-4
- β-fructosidase FosE activity in Lactobacillus paracasei regulates fructan degradation during sourdough fermentation and total FODMAP levels in steamed bread doi.org/10.1016/j.lwt.2021.111294
- THE ROLE OF ILLNESS PERCEPTIONS IN TREATMENT RESPONSE OF ADULTS WITH IBS UNDERGOING LOW FODMAP DIET INTERVENTION: A PROSPECTIVE STUDY. doi.org/10.1016/S0016-5085(21)02334-9
- MAST-CELL ACTIVATION LEADING TO COLONIC BARRIER DYSFUNCTION FOLLOWING HIGH-FODMAP DIET IS MEDIATED VIA LIPOPOLYSACCHARIDE doi.org/10.1016/S0016-5085(21)00924-0
- EVALUATING THE FACTUAL ACCURACY OF LOW FODMAP DIETARY CONTENT ON INSTAGRAM: A BLINDED, DIETITIAN-RATED ANALYSIS doi.org/10.1016/S0016-5085(21)02490-2
- FODMAPS, BUT NOT GLUTEN, ELICIT MODEST SYMPTOMS OF IRRITABLE BOWEL SYNDROME: DOUBLE-BLIND, PLACEBO-CONTROLLED RANDOMISED THREE-WAY CROSSOVER TRIAL doi.org/10.1016/S0016-5085(21)00927-6
- ARE ALL FODMAPS CREATED EQUAL? A BLINDED, RANDOMIZED REINTRODUCTION TRIAL TO DETERMINE WHICH FODMAPS DRIVE CLINICAL RESPONSE IN IBS PATIENTS doi.org/10.1016/S0016-5085(21)02493-8
- FODMAP Consumption by Adults from the French Population-Based NutriNet-Santé Cohort PMID: 34224572
- Efficacy of a low FODMAP diet in irritable bowel syndrome: systematic review and network meta-analysis PMID: 34376515
- Long-term personalized low FODMAP diet improves symptoms and maintains luminal Bifidobacteria abundance in irritable bowel syndrome PMID: 34431172
- Better response to low FODMAP diet in disorders of gut-brain interaction patients with pronounced hydrogen response to a nutrient challenge test PMID: 34107550
- Psychological and Gastrointestinal Symptoms of Patients with Irritable Bowel Syndrome Undergoing a Low-FODMAP Diet: The Role of the Intestinal Barrier PMID: 34371976
- Influence of low FODMAP-gluten free diet on gut microbiota alterations and symptom severity in Iranian patients with irritable bowel syndrome PMID: 34261437
- A Low-FODMAP Diet Improves the Global Symptoms and Bowel Habits of Adult IBS Patients: A Systematic Review and Meta-Analysis PMID: 34490319
- Effect of Low FODMAPs Diet on Irritable Bowel Syndromes: A Systematic Review and Meta-Analysis of Clinical Trials PMID: 34371973
- Correction to: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome: a systematic review and meta-analysis PMID: 34181070
- Diet Interventions for Irritable Bowel Syndrome: Separating the Wheat from the Chafe PMID: 34304788
- Designing New Foods or Food Ingredients Targeting the Gut Microbiota to Reduce FODMAP-Induced Irritable Bowel Syndrome (IBS) DOI:10.1016/B978-0-12-819265-8.00093-0
SIBO Related
- Mapping the Segmental Microbiomes in the Human Small Bowel in Comparison with Stool: A REIMAGINE Study. PMID: 32140945
- Optimizing microbiome sequencing for small intestinal aspirates: validation of novel techniques through the REIMAGINE study. PMID: 31675917
- Sa1925 —THERE ARE MAJOR DIFFERENCES BETWEEN LUMINAL AND MUCOSAL BACTERIAL COMPOSITION IN THE SMALL BOWEL OF HUMANS.
- Age and the aging process significantly alter the small bowel microbiome. PMID: 34592155
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