SIBO Associated Diseases
SIBO is associated with many disorders, as an underlying cause, an aftereffect of the pre-existing disease or as a co-existing condition. If you or one of your patients has one of the following conditions, testing and consideration of treatment for SIBO is merited. Click links for Studies.
Acne Rosacea, see a second study here, and a third here
Acne Vulgaris
Acromegaly
Age: Elderly
Alcohol Consumption (moderate intake)
Anemia
Autism
Celiac Disease, see below and see Tropical Sprue below
CLL (Chronic Lymphocytic Leukemia)
Cystic Fibrosis, see second study here, and a third here
Chronic Fatigue Syndrome
Diabetes, see second study here, and a third here
Diverticulitis, see a second study here
Erosive Esophagitis
Fibromyalgia, see a second study here
Gastroparesis, see a second study here
GERD (Gastroesophageal Reflux Disease), GERD & PPI's
H pylori Infection
Hypochlorhydria (low stomach acid)
Hypothyroid/Hashimoto's Throiditis
IBD (Inflammatory Bowel Disease), see below
-Crohn's
-Ulcerative Colitis
IBS (Irritable Bowel Syndrome), see below
Interstitial Cystitis
Lactose Intolerance
Leaky Gut or Leaky Small Intestine in this case (Increased Intestinal Permeability)
Liver Cirrhosis, see a second study here
Lyme
Malabsorption Syndrome
Medications: Proton Pump Inhibitors, see a second study here , Narcotics/Opioids
Muscular Dystrophy (myotonic Type 1)
NASH/ NAFLD (non-alcoholic steatohepatitis/non-alcoholic fatty liver disease), see a second study here, a third here
Obesity
Pancreatitis
Parasites
Parkinson's
Prostatitis, chronic
Restless Leg Syndrome, see a second study here, and a third here
Rheumatoid Arthritis
Scleroderma (Systemic Sclerosis), see a second study here
Surgery: Post Gastrectomy
Tropical Sprue, see a second study here, and a third here
Acne Rosacea, see a second study here, and a third here
Acne Vulgaris
Acromegaly
Age: Elderly
Alcohol Consumption (moderate intake)
Anemia
Autism
Celiac Disease, see below and see Tropical Sprue below
CLL (Chronic Lymphocytic Leukemia)
Cystic Fibrosis, see second study here, and a third here
Chronic Fatigue Syndrome
Diabetes, see second study here, and a third here
Diverticulitis, see a second study here
Erosive Esophagitis
Fibromyalgia, see a second study here
Gastroparesis, see a second study here
GERD (Gastroesophageal Reflux Disease), GERD & PPI's
H pylori Infection
Hypochlorhydria (low stomach acid)
Hypothyroid/Hashimoto's Throiditis
IBD (Inflammatory Bowel Disease), see below
-Crohn's
-Ulcerative Colitis
IBS (Irritable Bowel Syndrome), see below
Interstitial Cystitis
Lactose Intolerance
Leaky Gut or Leaky Small Intestine in this case (Increased Intestinal Permeability)
Liver Cirrhosis, see a second study here
Lyme
Malabsorption Syndrome
Medications: Proton Pump Inhibitors, see a second study here , Narcotics/Opioids
Muscular Dystrophy (myotonic Type 1)
NASH/ NAFLD (non-alcoholic steatohepatitis/non-alcoholic fatty liver disease), see a second study here, a third here
Obesity
Pancreatitis
Parasites
Parkinson's
Prostatitis, chronic
Restless Leg Syndrome, see a second study here, and a third here
Rheumatoid Arthritis
Scleroderma (Systemic Sclerosis), see a second study here
Surgery: Post Gastrectomy
Tropical Sprue, see a second study here, and a third here
Irritable Bowel Syndrome (IBS)
Dr's Pimentel and Lin originated the theory that SIBO is the underlying cause of IBS. As with all theories, there is debate and controversy about this idea, with many who agree and many who do not. One thing is certainly clear, the symptoms of SIBO overlap with those of IBS and a large percentage of IBS sufferers test positive for SIBO. One study by Dr Pimentel and team, showed SIBO in up to 84% of IBS patients, though this percentage has been lower in other studies. The vast majority of SIBO studies are on IBS.
See Dr Pimentel's:
Book/website- A New IBS Solution
Article- Irritable Bowel Syndrome: Bacterial Overgrowth--What's Known and What to Do (abstract)
Interview- Interview with Dr Pimentel from Sophie Lee's site: ibstales.com
See Dr Lin's:
Article- SIBO: A Framework for Understanding IBS
See Dr Weinstock's You Tube Video:
SIBO and Irritable Bowel Syndrome (IBS)
See Dr Pimentel's:
Book/website- A New IBS Solution
Article- Irritable Bowel Syndrome: Bacterial Overgrowth--What's Known and What to Do (abstract)
Interview- Interview with Dr Pimentel from Sophie Lee's site: ibstales.com
See Dr Lin's:
Article- SIBO: A Framework for Understanding IBS
See Dr Weinstock's You Tube Video:
SIBO and Irritable Bowel Syndrome (IBS)
Inflammatory Bowel Disease (IBD)- Crohn's and Ulcerative Colitis
SIBO has been linked in research with IBD (particularly Crohn's Disease- see below) but most notably, the predominant users of the Specific Carbohydrate Diet (SCD), the dietary treatment for SIBO are those with IBD. Several of the authors of SCD cookbooks were Ulcerative Colitis patients who state they cured themselves using the SCD.
Crohn's and SIBO
SIBO has been reported in 25% of Crohn's Disease patients. Dr Shafran reported in 2005 that 78% of Crohn's Disease patients had a 70-point improvement and a 59% remission rate after treatment with Rifaximin, the antibiotic used to treat SIBO. A more recent 2010 study from Dr Shafran reported a 70% remission rate from Rifaximin therapy.
See another study here.
Crohn's and SIBO
SIBO has been reported in 25% of Crohn's Disease patients. Dr Shafran reported in 2005 that 78% of Crohn's Disease patients had a 70-point improvement and a 59% remission rate after treatment with Rifaximin, the antibiotic used to treat SIBO. A more recent 2010 study from Dr Shafran reported a 70% remission rate from Rifaximin therapy.
See another study here.
Celiac Disease
Celiac disease is thought to be caused by an auto-immune response to gluten, but before the discovery of gluten in 1952, Dr Sidney V Haas proposed the theory of SIBO as the cause in his book The Management of Celiac Disease. He was influenced by the complete cure of celiac children he treated with his Specific Carbohydrate Diet (SCD) which goes beyond gluten-free to a grain-free diet. Elaine Gottschall discussed her support of Dr Haas's theory and her disagreement with the belief that gluten is the culprit in a chapter of her book, Breaking the Vicious Cycle. Read her article Whatever Happened to the Cure for Celiac Disease. Fascinating new information has been discovered relating to gluten and celiac disease in recent years, particularly the role of zonulin, discovered by Dr Fasano and team. How all of this fits together is not clear.
What is clear is that many Celiacs also have SIBO. Studies show this is prevalent in those who still have persistent or partial symptoms after gluten avoidance. Since bacteria eat the starch contained in all grains, SIBO offers an explanation why avoiding all grains, not just gluten grains, helps these patients. SIBO has also been suggested as an alternative explanation for latent celiac, where gliadin antibodies are elevated but little to no change is observed in the small intestine.
What is clear is that many Celiacs also have SIBO. Studies show this is prevalent in those who still have persistent or partial symptoms after gluten avoidance. Since bacteria eat the starch contained in all grains, SIBO offers an explanation why avoiding all grains, not just gluten grains, helps these patients. SIBO has also been suggested as an alternative explanation for latent celiac, where gliadin antibodies are elevated but little to no change is observed in the small intestine.
