2014 Research Articles

Overview

• Small intestinal bacterial overgrowth: what it is and what it is not.

• Current views on the etiopathogenesis, clinical manifestation, diagnostics, treatment and correlation with other nosological entities of SIBO.  PMID:25657082

• Pediatric small intestine bacterial overgrowth in low-income countries.  PMID:25486880

Causes/Risk Factors

• Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: a mechanistic approach.

• Low Ileocecal Valve Pressure Is Significantly Associated with Small Intestinal Bacterial Overgrowth (SIBO).  PMID: 24795035

• Motility abnormalities in irritable bowel syndrome.  PMID: 24503633
• Small Intestinal Transit Time is Delayed in Small Intestinal Bacterial Overgrowth.  PMID:25319735

• Autoimmunity Links Vinculin to the Pathophysiology of Chronic Functional Bowel Changes Following Campylobacter jejuni Infection in a Rat Model.  PMID:25424202
• The impact of proton pump inhibitors on the human gastrointestinal microbiome.  PMID:25439276

• Blind loop perforation after side-to-side ileocolonic anastomosis.  PMID:25161764

Associated Diseases

• Irritable bowel syndrome and small intestinal bacterial overgrowth: Meaningful association or unnecessary hype.

• Small intestinal bacterial overgrowth is associated to symptoms in irritable bowel syndrome. Evidence from a multicentre study in Romania.  PMID:25509557

• [Estimation of small intestinal bacterial overgrowth in patients with constipation and diarrhea irritable bowel syndrome].  PMID:24964506

• Microbiota, gastrointestinal infections, low-grade inflammation, and antibiotic therapy in irritable bowel syndrome: an evidence-based review.  PMID:24857420
• Prolonged orocecal transit time enhances serum bile acids through bacterial overgrowth, contributing factor to gallstone disease.
• Relationship of cytokines, oxidative stress and GI motility with bacterial overgrowth in ulcerative colitis patients.

• Ulcerative colitis as a polymicrobial infection characterized by sustained broken mucus barrier.  PMID:25071341

• Relapsing and refractory ulcerative colitis in children.  PMID:24969290

• SIBO in Gastroparesis: Sci-fi or Science Fact?

• Small intestinal bacterial overgrowth in gastroparesis.

• Pathological bacterial translocation in liver cirrhosis.

• Gastrointestinal dysfunction in liver cirrhosis.  PMID:25356031

• Small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis.  PMID: 24644547
• Gut-liver axis and probiotics: their role in non-alcoholic fatty liver disease.  PMID:25400436

• Small intestinal bacterial overgrowth in Parkinson's disease.  PMID: 24637123
• Liquid melevodopa versus standard levodopa in patients with Parkinson disease and small intestinal bacterial overgrowth.  PMID:24992085

• Role of small intestinal bacterial overgrowth in severe small intestinal damage in chronic non-steroidal anti-inflammatory drug users.  PMID: 24417613

• Methane intestinal production and poor metabolic control in type I diabetes complicated by autonomic neuropathy. PMID:25068305
• Digestive system dysfunction in cystic fibrosis: challenges for nutrition therapy.  PMID:25053610

• Cystic fibrosis: evidence for gut inflammation.  PMID:24548777

• An unusual cause of acute kidney injury due to oxalate nephropathy in systemic scleroderma.  PMID:25500295

• The role of intestinal bacteria overgrowth in obesity-related nonalcoholic fatty liver disease.  PMID:25479248

• Gut-liver axis and probiotics: their role in non-alcoholic fatty liver disease.

• Prevalence and predictors of small intestinal bacterial overgrowth in systemic sclerosis patients with gastrointestinal symptoms.  PMID:25372792

• Small intestinal bacterial overgrowth in inactive Crohn's disease: influence of thiopurine and biological treatment.  PMID:25320539

• Small intestinal bacterial overgrowth in patients with chronic pancreatitis.  PMID:25291129

• Small intestinal bacterial overgrowth is common both among patients with alcoholic and idiopathic chronic pancreatitis.  PMID:25062877

• An insight into the gastrointestinal component of fibromyalgia: clinical manifestations and potential underlying mechanisms.  PMID:25119830

• The gut microbiome and the brain.  PMID:25402818

• Link between hypothyroidism and small intestinal bacterial overgrowth.  PMID:24944923

Migrating Motor Complex

• [Effects of acupuncture at "Tianshu" (ST 25) on electro-activity and mechanical motility of migrating motor complex during jejunal digestion period in rats with detached jejunum].  PMID:25022121
• Endogenous motilin, but not ghrelin plasma levels fluctuate in accordance with gastric phase III activity of the migrating motor complex in man.  PMID:25393165

• Motilin-induced gastric contractions signal hunger in man.  PMID:25539673

Testing

• SIBO: The Finer Points of Diagnosis, Test Interpretation, and Treatment
• Increasing duodenal intraepithelial lymphocytosis found at upper endoscopy: time trends and associations.
• Breath tests in the diagnosis of small intestinal bacterial overgrowth in patients with irritable bowel syndrome in comparison with quantitative upper gut aspirate culture.  PMID: 24849768
• A study of the methodological and clinical validity of the combined lactulose hydrogen breath test with scintigraphic oro-cecal transit test for diagnosing small intestinal bacterial overgrowth in IBS patients.  PMID: 24641100
• Breath tests and irritable bowel syndrome.  PMID:24976698

• Glucose Hydrogen Breath Test for Small Intestinal Bacterial Overgrowth in Children with Abdominal Pain-Related Functional Gastrointestinal Disorders.  PMID:25406525

• Hydrogen breath tests in gastrointestinal diseases.  PMID:25298621

• Associations between IL-1RA polymorphisms and small intestinal bacterial overgrowth among patients with irritable bowel syndrome from India.  PMID:25073651

• Breath testing for small intestinal bacterial overgrowth: maximizing test accuracy.  PMID:24095975

• Small intestinal bacterial overgrowth is an uncommon cause of false positive lactose hydrogen breath test among patients with diarrhoea-predominant irritable bowel syndrome in Asia.  PMID:25470082

Treatment: Herbal Antibiotics

• Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth.  PMID: 24891990

Treatment: Antibiotics

• In vitro activity of rifaximin against isolates from patients with small intestinal bacterial overgrowth.

• Is generic rifaximin still a poorly absorbed antibiotic? A comparison of branded and generic formulations in healthy volunteers.  PMID: 24836868
• Impact of crystal polymorphism on the systemic bioavailability of rifaximin, an antibiotic acting locally in the gastrointestinal tract, in healthy volunteers.  PMID:25565769
• Antibiotic treatment of constipation-predominant irritable bowel syndrome.  PMID: 24788320
• Safety and tolerability of rifaximin for the treatment of irritable bowel syndrome without constipation: a pooled analysis of randomised, double-blind, placebo-controlled trials.  PMID: 24697851
• Rifaximin for small intestinal bacterial overgrowth in patients without irritable bowel syndrome.  PMID:25319626

• Rifaximin, gut microbes and mucosal inflammation: unraveling a complex relationship.  PMID:25244596

• Editorial: safety and tolerability of rifaximin for IBS - more information is required; authors' reply.  PMID:24946060

• Editorial: safety and tolerability of rifaximin for IBS - more information is required.  PMID:24946058

Probiotics

• Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study.  PMID:25579140

• Short-term probiotic therapy alleviates small intestinal bacterial overgrowth, but does not improve intestinal permeability in chronic liver disease.  PMID:25244414
• Probiotics, prebiotics & synbiotics in small intestinal bacterial overgrowth: opening up a new therapeutic horizon!  PMID:25579137

Low FODMAP Diet    

• Dietary fructose intolerance, fructan intolerance and FODMAPs.

• A study of the methodological and clinical validity of the combined lactulose hydrogen breath test with scintigraphic oro-cecal transit test for diagnosing small intestinal bacterial overgrowth in IBS patients.

• Gut microbiota influences low fermentable substrate diet efficacy in children with irritable bowel syndrome.

• Role of dietary FODMAPs in IBS-related symptoms.

• Differential effects of FODMAPs (fermentable oligo-, di-, mono-saccharides and polyols) on small and large intestinal contents in healthy subjects shown by MRI.

• A diet low in FODMAPs reduces symptoms of irritable bowel syndrome.

• [Malabsorption of fermentable oligo-, di-, or monosaccharides and polyols (FODMAP) as a common cause of unclear abdominal discomfort].  - German  PMID: 24892470

• Fermentable oligosaccharides, disaccharides, monosaccharides and polyols: role in irritable bowel syndrome.  PMID: 24830318
• [The low FODMAP diet as a therapy for irritable bowel syndrome]. - In Dutch  PMID: 24823855
• Low FODMAP Diet in the Treatment of Irritable Bowel Syndrome: Is It the End of the Road or the Beginning of a Journey? PMID: 24780209  

• Mechanisms and efficacy of dietary FODMAP restriction in IBS.  PMID: 24445613
• Dietary sorbitol and mannitol: food content and distinct absorption patterns between healthy individuals and patients with irritable bowel syndrome.  PMID: 23909813 

• Fructose Malabsorption in Patients With Irritable Bowel Syndrome-like Symptoms: What Is the Role in the Pathogenesis and Clinical Implication?  PMID: 24840365

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