SIBO - Small Intestinal Bacterial Overgrowth
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2014 Research Articles

Overview
  • Small intestinal bacterial overgrowth: what it is and what it is not.
  • Current views on the etiopathogenesis, clinical manifestation, diagnostics, treatment and correlation with other nosological entities of SIBO.  PMID:25657082
  • Pediatric small intestine bacterial overgrowth in low-income countries.  PMID:25486880

Causes/Risk Factors
  • Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: a mechanistic approach.
  • Low Ileocecal Valve Pressure Is Significantly Associated with Small Intestinal Bacterial Overgrowth (SIBO).  PMID: 24795035
  • Motility abnormalities in irritable bowel syndrome.  PMID: 24503633
  • Small Intestinal Transit Time is Delayed in Small Intestinal Bacterial Overgrowth.  PMID:25319735
  • Autoimmunity Links Vinculin to the Pathophysiology of Chronic Functional Bowel Changes Following Campylobacter jejuni Infection in a Rat Model.  PMID:25424202
  • The impact of proton pump inhibitors on the human gastrointestinal microbiome.  PMID:25439276
  • Blind loop perforation after side-to-side ileocolonic anastomosis.  PMID:25161764

Associated Diseases
  • Irritable bowel syndrome and small intestinal bacterial overgrowth: Meaningful association or unnecessary hype.
  • Small intestinal bacterial overgrowth is associated to symptoms in irritable bowel syndrome. Evidence from a multicentre study in Romania.  PMID:25509557
  • [Estimation of small intestinal bacterial overgrowth in patients with constipation and diarrhea irritable bowel syndrome].  PMID:24964506
  • Microbiota, gastrointestinal infections, low-grade inflammation, and antibiotic therapy in irritable bowel syndrome: an evidence-based review.  PMID:24857420
  • Prolonged orocecal transit time enhances serum bile acids through bacterial overgrowth, contributing factor to gallstone disease.
  • Relationship of cytokines, oxidative stress and GI motility with bacterial overgrowth in ulcerative colitis patients.
  • Ulcerative colitis as a polymicrobial infection characterized by sustained broken mucus barrier.  PMID:25071341
  • Relapsing and refractory ulcerative colitis in children.  PMID:24969290
  • SIBO in Gastroparesis: Sci-fi or Science Fact?
  • Small intestinal bacterial overgrowth in gastroparesis.
  • Pathological bacterial translocation in liver cirrhosis.
  • Gastrointestinal dysfunction in liver cirrhosis.  PMID:25356031
  • Small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis.  PMID: 24644547
  • Gut-liver axis and probiotics: their role in non-alcoholic fatty liver disease.  PMID:25400436
  • Small intestinal bacterial overgrowth in Parkinson's disease.  PMID: 24637123
  • Liquid melevodopa versus standard levodopa in patients with Parkinson disease and small intestinal bacterial overgrowth.  PMID:24992085
  • Role of small intestinal bacterial overgrowth in severe small intestinal damage in chronic non-steroidal anti-inflammatory drug users.  PMID: 24417613
  • Methane intestinal production and poor metabolic control in type I diabetes complicated by autonomic neuropathy. PMID:25068305
  • Digestive system dysfunction in cystic fibrosis: challenges for nutrition therapy.  PMID:25053610
  • Cystic fibrosis: evidence for gut inflammation.  PMID:24548777
  • An unusual cause of acute kidney injury due to oxalate nephropathy in systemic scleroderma.  PMID:25500295
  • The role of intestinal bacteria overgrowth in obesity-related nonalcoholic fatty liver disease.  PMID:25479248
  • Gut-liver axis and probiotics: their role in non-alcoholic fatty liver disease.
  • Prevalence and predictors of small intestinal bacterial overgrowth in systemic sclerosis patients with gastrointestinal symptoms.  PMID:25372792
  • Small intestinal bacterial overgrowth in inactive Crohn's disease: influence of thiopurine and biological treatment.  PMID:25320539
  • Small intestinal bacterial overgrowth in patients with chronic pancreatitis.  PMID:25291129
  • Small intestinal bacterial overgrowth is common both among patients with alcoholic and idiopathic chronic pancreatitis.  PMID:25062877
  • An insight into the gastrointestinal component of fibromyalgia: clinical manifestations and potential underlying mechanisms.  PMID:25119830
  • The gut microbiome and the brain.  PMID:25402818
  • Link between hypothyroidism and small intestinal bacterial overgrowth.  PMID:24944923

Migrating Motor Complex
  • [Effects of acupuncture at "Tianshu" (ST 25) on electro-activity and mechanical motility of migrating motor complex during jejunal digestion period in rats with detached jejunum].  PMID:25022121
  • Endogenous motilin, but not ghrelin plasma levels fluctuate in accordance with gastric phase III activity of the migrating motor complex in man.  PMID:25393165
  • Motilin-induced gastric contractions signal hunger in man.  PMID:25539673

Testing
  • SIBO: The Finer Points of Diagnosis, Test Interpretation, and Treatment
  • Increasing duodenal intraepithelial lymphocytosis found at upper endoscopy: time trends and associations.
  • Breath tests in the diagnosis of small intestinal bacterial overgrowth in patients with irritable bowel syndrome in comparison with quantitative upper gut aspirate culture.  PMID: 24849768
  • A study of the methodological and clinical validity of the combined lactulose hydrogen breath test with scintigraphic oro-cecal transit test for diagnosing small intestinal bacterial overgrowth in IBS patients.  PMID: 24641100
  • Breath tests and irritable bowel syndrome.  PMID:24976698
  • Glucose Hydrogen Breath Test for Small Intestinal Bacterial Overgrowth in Children with Abdominal Pain-Related Functional Gastrointestinal Disorders.  PMID:25406525
  • Hydrogen breath tests in gastrointestinal diseases.  PMID:25298621
  • Associations between IL-1RA polymorphisms and small intestinal bacterial overgrowth among patients with irritable bowel syndrome from India.  PMID:25073651
  • Breath testing for small intestinal bacterial overgrowth: maximizing test accuracy.  PMID:24095975
  • Small intestinal bacterial overgrowth is an uncommon cause of false positive lactose hydrogen breath test among patients with diarrhoea-predominant irritable bowel syndrome in Asia.  PMID:25470082

Treatment: Herbal Antibiotics
  • Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth.  PMID: 24891990

Treatment: Antibiotics
  • In vitro activity of rifaximin against isolates from patients with small intestinal bacterial overgrowth.
  • Is generic rifaximin still a poorly absorbed antibiotic? A comparison of branded and generic formulations in healthy volunteers.  PMID: 24836868
  • Impact of crystal polymorphism on the systemic bioavailability of rifaximin, an antibiotic acting locally in the gastrointestinal tract, in healthy volunteers.  PMID:25565769
  • Antibiotic treatment of constipation-predominant irritable bowel syndrome.  PMID: 24788320
  • Safety and tolerability of rifaximin for the treatment of irritable bowel syndrome without constipation: a pooled analysis of randomised, double-blind, placebo-controlled trials.  PMID: 24697851
  • Rifaximin for small intestinal bacterial overgrowth in patients without irritable bowel syndrome.  PMID:25319626
  • Rifaximin, gut microbes and mucosal inflammation: unraveling a complex relationship.  PMID:25244596
  • Editorial: safety and tolerability of rifaximin for IBS - more information is required; authors' reply.  PMID:24946060
  • Editorial: safety and tolerability of rifaximin for IBS - more information is required.  PMID:24946058

Probiotics
  • Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study.  PMID:25579140
  • Short-term probiotic therapy alleviates small intestinal bacterial overgrowth, but does not improve intestinal permeability in chronic liver disease.  PMID:25244414
  • Probiotics, prebiotics & synbiotics in small intestinal bacterial overgrowth: opening up a new therapeutic horizon!  PMID:25579137

Low FODMAP Diet    
  • Dietary fructose intolerance, fructan intolerance and FODMAPs.
  • A study of the methodological and clinical validity of the combined lactulose hydrogen breath test with scintigraphic oro-cecal transit test for diagnosing small intestinal bacterial overgrowth in IBS patients.
  • Gut microbiota influences low fermentable substrate diet efficacy in children with irritable bowel syndrome.
  • Role of dietary FODMAPs in IBS-related symptoms.
  • Differential effects of FODMAPs (fermentable oligo-, di-, mono-saccharides and polyols) on small and large intestinal contents in healthy subjects shown by MRI.
  • A diet low in FODMAPs reduces symptoms of irritable bowel syndrome.
  • [Malabsorption of fermentable oligo-, di-, or monosaccharides and polyols (FODMAP) as a common cause of unclear abdominal discomfort].  - German  PMID: 24892470
  • Fermentable oligosaccharides, disaccharides, monosaccharides and polyols: role in irritable bowel syndrome.  PMID: 24830318
  • [The low FODMAP diet as a therapy for irritable bowel syndrome]. - In Dutch  PMID: 24823855
  • Low FODMAP Diet in the Treatment of Irritable Bowel Syndrome: Is It the End of the Road or the Beginning of a Journey? PMID: 24780209  
  • Mechanisms and efficacy of dietary FODMAP restriction in IBS.  PMID: 24445613
  • Dietary sorbitol and mannitol: food content and distinct absorption patterns between healthy individuals and patients with irritable bowel syndrome.  PMID: 23909813 
  • Fructose Malabsorption in Patients With Irritable Bowel Syndrome-like Symptoms: What Is the Role in the Pathogenesis and Clinical Implication?  PMID: 24840365
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