SIBO - Small Intestinal Bacterial Overgrowth
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2018 Research Articles

Overview
  • Small Intestinal Bacterial Overgrowth: Nutritional Implications, Diagnosis, and Management.  PMID: 29413012 
  • Risk Factors Associated With Upper Aerodigestive Tract or Coliform of the in Symptomatic Patients.  PMID: 30575635

Underlying Causes (pathophysiological)
  • Vagal dysfunction and small intestinal bacterial overgrowth: novel pathways to chronic inflammation in HIV.  PMID: 29596112  
   ICC (Interstitial Cells of Cajal)
  • Electroacupuncture at ST36 Increases Bone Marrow-Derived Interstitial Cells of Cajal via the SDF-1/CXCR4 and mSCF/Kit-ETV1 Pathways in the Stomach of Diabetic Mice.  PMID: 29599809


Pathophysiology
  • Characterization of Small Intestine Microbiotia in Patients Undergoing Evaluation for Suspected SIBO
  • A SUBSET OF SYMPTOMATIC PATIENTS EXHIBIT SMALL INTESTINAL DYSBIOSIS IRRESPECTIVE OF QUANTITATIVE DUODENAL ASPIRATE CULTURE RESULTS.
  • Neither Serum Vitamin B12 nor Methylmalonic Acid Values are Reliable Markers of Vitamin B12 Sufficiency in Children with Short Bowel Syndrome
  • ANTIBODIES TO CAMPYLOBACTER JEJUNI-DERIVED CYTOLETHAL DISTENDING TOXIN B AND HUMAN VINCULIN LOCALIZE TO THE GASTROINTESTINAL TRACT AFTER IN VIVO ACUTE ADMINISTRATION
   Bloating:
  • Abdominal distension in health and irritable bowel syndrome: The effect of bladder filling.  PMID: 30070066


Causes/Risk Factors
    Antibiotics
  • ANTIBIOTICS IMPAIR GASTRIC EMPTYING 6 WEEKS AFTER COMPLETION OF TREATMENT IN MICE
    Diseases
  • Microbiome-Gut-Brain Axis and Toll-Like Receptors in Parkinson's Disease. PMID:  29882798
  • ANTIBODIES TO CAMPYLOBACTER JEJUNI-DERIVED CYTOLETHAL DISTENDING TOXIN B AND HUMAN VINCULIN LOCALIZE TO THE GASTROINTESTINAL TRACT AFTER IN VIVO ACUTE ADMINISTRATION

    PPI's/Hypochlorhydria 
  • Intestinal Dysbiosis Secondary to Proton-Pump Inhibitor Use.  PMID: 29316555
  • Is It Useful to Administer Probiotics Together With Proton Pump Inhibitors in Children With Gastroesophageal Reflux?  PMID: 29291607
  • Risk of small intestinal bacterial overgrowth in patients receiving proton pump inhibitors versus proton pump inhibitors plus prokinetics: Small intestinal bacterial overgrowth.  DOI: 10.1002/jgh3.12045
  • Bowel symptoms in patients that receive proton pump inhibitors. Results of a multicenter survey in Mexico.  PMID: 29678362
  • Proton Pump Inhibitors: Risks and Rewards and Emerging Consequences to the Gut Microbiome.  PMID: 30071147
  • Proton pump inhibitors are associated to minimal and overt hepatic encephalopathy and increase mortality in cirrhotics.  PMID: 30289992
  • Association of proton pump inhibitors with the risk of hepatic encephalopathy during hospitalization for liver cirrhosis.  PMID: 30288280
  
   Surgery 
  • Cirrhosis following single anastomosis duodeno-ileal switch: A case report.  PMID: 29605778  
  • Chronic diarrhoea following surgery for colon cancer-frequency, causes and treatment options.  PMID: 29589108
  • The gut-liver axis: impact of a mouse model of small-bowel bacterial overgrowth.  PMID: 29229136
  • Resolution of late-onset heart and liver failures after reversion of jejuno-ileal bypass: a case report.  PMID: 29790800
  • Does colectomy predispose to small intestinal bacterial (SIBO) and fungal overgrowth (SIFO)?  PMID: 29691369
  • Bacteria, Bones, and Stones: Managing Complications of Short Bowel Syndrome.  PMID: 29926935
  • Intestinal manipulation affects mucosal antimicrobial defense in a mouse model of postoperative ileus.  PMID: 29652914
  • Small intestinal bacterial overgrowth (SIBO) and vitamin K-responsive coagulopathy: a previously unrecorded association.  PMID: 29880619
  • SIBO: Clinical Presentation in Patients with Roux-En-Y Gastric Bypass
  • Small intestinal bacterial overgrowth is common after gastrectomy but with little impact on nutritional status.  PMID: 30197248
  • Gut Microbiota Imbalance Can Be Associated with Non-malabsorptive Small Bowel Shortening Regardless of Blind Loop.  PMID: 30293133


Associated Conditions
   Amyloidosis  New
  • Majority of Patients with GI Amyloidosis have Upper Gut Mucosal Involvement on Biopsy and Improve with Small Bowel Bacterial Overgrowth Treatment
   Bowel-associated dermatosis-arthritis syndrome (BADAS)  New    
  • Bowel-associated dermatosis-arthritis syndrome (BADAS) in a patient with cystic fibrosis.  PMID: 30581933
   Brain Fog
  • Response to Sachdeva et al: Brain Fogginess and Is Not a Mirage.  PMID: 30291226 
   Childhood Stunted Growth  New
  • Stunted childhood growth is associated with decompartmentalization of the gastrointestinal tract and overgrowth of oropharyngeal taxa.  PMID: 30126990
  • Early Life Interventions for Childhood Growth and Development in Tanzania (ELICIT): a protocol for a randomized factorial, double-blind, placebo-controlled trial of azithromycin, nitazoxanide and nicotinamide.  PMID: 29982218
  • Impact of Small Intestine Bacterial Overgrowth on Response to a Nutritional Intervention in Bangladeshi Children from an Urban Community.  PMID: 30479249
  • Dosing of Ceftriaxone and Metronidazole for Children With Severe Acute Malnutrition.  PMID: 29574688
   Chronic Idiopathic Pseudo Obstruction
  • Pathophysiology, Diagnosis, and Management of Chronic Intestinal Pseudo-Obstruction.  PMID: 29877952
  • SEVERE GASTROINTESTINAL DYSMOTILITY RELATED INTESTINAL FAILURE: CHRONIC INTESTINAL PSEUDO-OBSTRUCTION, ENTERIC DYSMOTILITY OR A ‘PRAGMATIC’ APPROACH? EXPERIENCE FROM A UK NATIONAL REFERRAL CENTRE
  • The chronic pseudo-obstruction subtype has prognostic significance in patients with severe gastrointestinal dysmotility related failure.  PMID: 30290972
   Clostridium Difficile
  • Clostridium difficile, the Difficult "Kloster" Fuelled by Antibiotics.  PMID: 30084095
   Coronary Artery Disease
  • Small Intestinal Bacterial Overgrowth and Coronary Artery Disease: What Is in the CArDs?  PMID: 29307000
  • Excess Alcohol Consumption: A Potential Mechanism Behind the Association Between and Coronary Artery Disease.  PMID: 30367306
   Cystic Fibrosis
  • The role of small intestinal bacterial overgrowth in cystic fibrosis: a randomized case-controlled clinical trial with rifaximin.  PMID: 30232597
  • Bowel-associated dermatosis-arthritis syndrome (BADAS) in a patient with cystic fibrosis.  PMID: 30581933
    D-Lactic Acidosis  New
  • Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis.  PMID: 29915215
  • Brain Fogginess and SIBO: A Link or Just a Mirage?  PMID: 30237404
  • Response to Sachdeva et al: Brain Fogginess and SIBO Is Not a Mirage.  PMID: 30291226
  • Stoned-A Syndrome of D-Lactic Acidosis and Urolithiasis.  PMID: 29570851
   Diabetes
  • Type 1 diabetes mellitus: Complex interplay of oxidative stress, cytokines, gastrointestinal motility and small intestinal bacterial overgrowth.  PMID: 30155878
   Dyspepsia
  • High Prevalence of Pathological Hydrogen Breath Tests in Patients with Functional Dyspepsia.  PMID: 30428469
   Gallstones
  • The characteristics of small intestinal bacterial overgrowth in patients with gallstone diseases.  PMID: 29392773
   Heart Failure  NEW
  • Hydrogen- and Methane-Based Breath Testing and Outcomes in Patients With Heart Failure.  PMID: 30347272
  • Design of the GutHeart-targeting gut microbiota to treat heart failure-trial: a Phase II, randomized clinical trial.  PMID: 30088346
   HIV  New
  • Vagal dysfunction and small intestinal bacterial overgrowth: novel pathways to chronic inflammation in HIV.  PMID: 29596112
   H pylori
  • Restless legs syndrome in patients infected with Helicobacter pylori.  PMID: 29623817
   IBD
  • Testing and Treating Small Intestinal Bacterial Overgrowth Reduces Symptoms in Patients with Inflammatory Bowel Disease.  PMID: 29761252
   Intestinal Failure
  • Serum Unconjugated Bile Acids and Small Bowel Bacterial Overgrowth in Pediatric Intestinal Failure: A Pilot Study.  PMID: 30035316
   IBS
  • The gut microbiome and irritable bowel syndrome: State of art review.  PMID: 29935865
  • Prevalence and predictors of small intestinal bacterial overgrowth in irritable bowel syndrome: a systematic review and meta-analysis.  PMID: 29761234
  • Evaluation of chronic diarrhea and irritable bowel syndrome with diarrhea in adults in the era of precision medicine.  PMID: 29713027
  • Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome.  PMID: 30009817
  • Fecal Microbiota Alterations Associated With Diarrhea-Predominant Irritable Bowel Syndrome.  PMID: 30090090
  • Double-Blind Placebo-Controlled Study of Rifaximin and Lactulose Hydrogen Breath Test in Gulf War Veterans with Irritable Bowel Syndrome.  PMID: 30370492
  • Declining Rates of Referral for Irritable Bowel Syndrome Without Constipation at a Tertiary Care Center.  PMID: 30324554
  • Systematic review with meta-analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome.  PMID: 30294792
  • Changes in Fecal Calprotectin After Rifaximin Treatment in Patients With Nonconstipated Irritable Syndrome.  PMID: 30611316
   Kidney Stones (urolithiasis)
  • Stoned-A Syndrome of D-Lactic Acidosis and Urolithiasis.  PMID: 29570851
   Klein-Levin Syndrome  New 
  • Kleine-Levin syndrome: the contribution of PET scan and hydrogen breath test for small intestinal bacterial overgrowth.  PMID: 29773218
   Leaky Gut
  • Recognizing the leaky gut as a trans-diagnostic target for neuro-immune disorders using clinical chemistry and molecular immunology assays.  PMID: 30430944
   Liver Disease
  • The role of intestinal microbiota in the pathogenesis of NAFLD: starting points for intervention.  PMID: 2976546
  • Pattern of Hydrogen and Methane Production by Gut Microbiome in Non-Alcoholic Disease (NAFLD): A Large-Scale Matched Case-Control Study
  • Bile Acid-Induced Activation of ERK/Sphingosine Kinase 2 contributes to Intestinal Inflammation and Barrier Dysfunction in Multi-Drug Resistance 2 Gene Deficient Mice
  • The Prevalence of SIBO in Adults with Non-alcoholic Fatty Liver Disease
  • Resolution of late-onset heart and liver failures after reversion of jejuno-ileal bypass: a case report.  PMID: 29790800
  • Clinical impact of microbiome in patients with decompensated cirrhosis.  PMID: 30228776
  • Small intestinal bacterial overgrowth in cirrhosis: systematic review and meta-analysis.  PMID: 30284684
  • Infectious Complications in Critically Ill Liver Failure Patients.  PMID: 30485888
  • Combining probiotics and an angiotensin-II type 1 receptor blocker has beneficial effects on hepatic fibrogenesis in a rat model of non-alcoholic steatohepatitis.  PMID: 30365236
   Marfan Syndrome New
  • Small Bowel Diverticulosis and Jejunal Perforation in Marfan Syndrome.  PMID: 29392152
   MCAS (Mast Cell Activation Syndrome) New
  • Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment.  PMID: 9326369
   Obesity
  • Obesity increases the risk of small intestinal bacterial overgrowth (SIBO).  PMID: 28940740
   Pancreatic Disease
  • The prevalence of small intestinal bacterial overgrowth in non-surgical patients with chronic pancreatitis and pancreatic exocrine insufficiency (PEI).  PMID: 29502987
  • Small intestine bacterial overgrowth in chronic pancreatitis.  DOI: 10.25121/PNM.2017.30.11.619
  • Chronic pancreatitis and small intestinal bacterial overgrowth.  PMID: 29752215
  • Diagnosis and Management of Exocrine Pancreatic Insufficiency.  PMID: 30027527
  • Association between small intestinal bacterial overgrowth and toll-like receptor 4 in patients with pancreatic carcinoma and cholangiocarcinoma.  PMID: 30457560
   Parkinson’s disease
  • Small intestinal bacterial overgrowth in Parkinson's disease: Tribulations of a trial.  PMID: 29636215
  • Microbiome-Gut-Brain Axis and Toll-Like Receptors in Parkinson's Disease. PMID:  29882798
  • Weight Loss in Parkinson's Disease: No Evidence for Role of Small Intestinal Bacterial Overgrowth.  PMID: 30149465
  • Parkinson's Disease and Current Treatments for Its Gastrointestinal Neurogastromotility Effects.  PMID: 30361854
   POTS (Postural Orthostatic Tachycardia Syndrome)  New 
  • Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment.  PMID: 9326369
  • The gastrointestinal symptoms present in patients with postural tachycardia syndrome: A review of the literature and overview of treatment. https://doi.org/10.1016/j.autneu.2018.09.003
  • Evaluation of postural tachycardia syndrome (POTS).  PMID: 29705015
   Psoriasis
  • Oral psoriasis and sibo: is there a link?  PMID: 29575224
   Restless Legs
  • Restless legs syndrome in patients infected with Helicobacter pylori.  PMID: 29623817
   Rosacea
  • The association between cigarettes smoke, small intestine bacterial overgrowth and rosacea.  PMID: 29485256
   Short Bowel Syndrome
  • Bacteria, Bones, and Stones: Managing Complications of Short Bowel Syndrome.  PMID: 29926935
  • Starch Tolerance and the Short Bowel.  PMID: 29762383
  • Neither Serum Vitamin B12 nor Methylmalonic Acid Values are Reliable Markers of Vitamin B12 Sufficiency in Children with Short Bowel Syndrome
  • Remnant Small Bowel Length in Pediatric Short Bowel Syndrome and the Correlation with Intestinal Dysbiosis and Linear Growth.  PMID: 30077861  
  • Stoned-A Syndrome of D-Lactic Acidosis and Urolithiasis.  PMID: 29570851
   Surgery (Bariatric)
  • Gut Microbiota Imbalance Can Be Associated with Non-malabsorptive Small Bowel Shortening Regardless of Blind Loop.  PMID: 30293133
   Systemic Sclerosis
  • Intestinal Involvement in Systemic Sclerosis: A Clinical Review.  PMID: 29464583
  • Small intestinal bacterial overgrowth in systemic sclerosis: a review of the literature.  PMID: 30382339
  • Treatment of small intestinal bacterial overgrowth in systemic sclerosis: a systematic review.  PMID: 29982822
   Thyroid
  • [Thyroid dysfunction in patients with small intestinal bacterial overgrowth]. Polish.  PMID: 29374417
   Vitamin B12 Deficiency
  • Neither Serum Vitamin B12 nor Methylmalonic Acid Values are Reliable Markers of Vitamin B12 Sufficiency in Children with Short Bowel Syndrome
   Vitamin K-Responsive Coagulopathy  New
  • Small intestinal bacterial overgrowth (SIBO) and vitamin K-responsive coagulopathy: a previously unrecorded association.  PMID: 29880619

 
Testing
  • The North American Consensus on Breath Testing: The Controversial Diagnostic Role of Lactulose in SIBO.  PMID: 29535443
  • Does a glucose-based hydrogen and methane breath test detect bacterial overgrowth in the jejunum?  PMID: 29687525
  • Case of small intestinal bacterial overgrowth carried out by capsule and double-balloon endoscopy.  PMID: 29729056
  • Investigation of SIBO in Diabetics Using Fructose Breath Test
  • Does Bowel Preparation Affect Duodenal Aspirate Culture for SIBO?
  • Comparative Quantitative Analysis Between the North American Consensus Positive Hydrogen Breath Test- SIBO Versus Traditional Thresholds
  • The Convergence of Bacterial Overgrowth, Systemic Inflammatory Biomarkers, and Anti-Vinculin Antibodies in Determining the Response to Rifaximin Treatment in Diarrheal-Predominant IBS Subjects
  • ANTIBODIES TO CAMPYLOBACTER JEJUNI-DERIVED CYTOLETHAL DISTENDING TOXIN B AND HUMAN VINCULIN LOCALIZE TO THE GASTROINTESTINAL TRACT AFTER IN VIVO ACUTE ADMINISTRATION
  • Validation of a 4-Gas Device for Breath Testing in the Determination of Small Intestinal Bacterial Overgrowth
  • The safety and sensitivity of a telemetric capsule to monitor gastrointestinal hydrogen production in vivo in healthy subjects: a pilot trial comparison to concurrent breath analysis.  PMID: 30067289
  • Serum Unconjugated Bile Acids and Small Bowel Bacterial Overgrowth in Pediatric Intestinal Failure: A Pilot Study.  PMID: 30035316
  • NON-INVASIVE DIAGNOSIS OF IRRITABLE BOWEL SYNDROME VIA NOVEL BOWEL SOUND FEATURES: PROOF OF PRINCIPLE
  • Neither Serum Vitamin B12 nor Methylmalonic Acid Values are Reliable Markers of Vitamin B12 Sufficiency in Children with Short Bowel Syndrome
  • The diagnosis of : Two steps forward, one step backwards?  PMID: 30328232
  • Gastroduodenal "Dysbiosis": a New Clinical Entity.  PMID: 30421297


Methane
  • Effect of Bifidobacterium infantis 35624 (Align) on the Lactulose Breath Test for Small Intestinal Bacterial Overgrowth.  PMID: 29397491
  • Elevated methane levels in small intestinal bacterial overgrowth suggests delayed small bowel and colonic transit.  PMID: 29794732
  • Competitive Hydrogen Gas Utilization by Methane – and Hydrogen Sulfide-Producing Microorganisms and Associated Symptoms: Results of a Novel 4-Gas Breath Testing Machine
  • Breath methane concentrations and markers of obesity in patients with functional gastrointestinal disorders.  PMID: 29881615
  • IMPROVEMENTS IN METABOLIC PARAMETERS IN PRE-DIABETIC SUBJECTS WITH OBESITY FOLLOWING METHANE ERADICATION IS ASSOCIATED WITH REDUCTION IN METHANOGENS AND CHANGES IN GUT MICROBIAL POPULATIONS
  • ERADICATION OF BREATH METHANE USING ANTIBIOTICS RESULTS IN CHANGES IN SHORT CHAIN FATTY ACID LEVELS IN PREDIABETIC SUBJECTS WITH OBESITY
  • PREVALENCE OF METHANOGENS AND ASSOCIATED FACTORS IN PATIENTS WITH IRRITABLE BOWEL SYNDROME (IBS) AND HEALTHY CONTROLS IN A MEXICAN POPULATION
  • A randomized double-blind placebo-controlled trial showing to improve constipation by reducing methane production and accelerating colon transit: A pilot study.  PMID: 30406392
  • Zengye decoction induces alterations to metabolically active gut microbiota in aged constipated rats.  PMID: 30551387
 

Hydrogen Sulfide
  • Hydrogen sulfide in physiology and pathogenesis of bacteria and viruses. PMID: 29601123
  • Breath Hydrogen Sulfide Does Not Correlate With Constipation
  • A Novel 4-Gas Device for Breath Testing Shows Exhaled H2S is Associated with Diarrhea and Abdominal Pain in a Large Scale Prospective Trial
  • Validation of a 4-Gas Device for Breath Testing in the Determination of Small Intestinal Bacterial Overgrowth
  • Competitive Hydrogen Gas Utilization by Methane – and Hydrogen Sulfide-Producing Microorganisms and Associated Symptoms: Results of a Novel 4-Gas Breath Testing Machine
  • Presence of Hydrogen Consumptive Microbes Increases Peak of Hydrogen Concentration
  • DIETARY EMULSIFIER POLYSORBATE-80 INCREASES THE PROTEUS GENUS AND EXACERBATES INTESTINAL INFLAMMATION ON INDMETHACIN-INDUCED ILEITIS
  • Zengye decoction induces alterations to metabolically active gut microbiota in aged constipated rats.  PMID: 30551387


Treatment
  •  New treatments and therapeutic targets for IBS and other functional bowel disorders.  PMID: 29930260
  • Naturopathic Approaches to Irritable Bowel Syndrome—A Delphi Study. http://doi.org/10.1089/acm.2018.0255
  • Efficacy of glutamine in postinfection IBS.  PMID: 30244201
  
   Antibiotics: Rifaximin
  • Status of Rifaximin: A Review of Characteristics, Uses and Analytical Methods.  PMID: 29580065
  • Gut Microbiota-Based Therapies for Irritable Bowel Syndrome.  PMID: 29446765
  • Evidence-based management of irritable bowel syndrome with diarrhea.  PMID: 29372991
  • Pharmacokinetic drug evaluation of rifaximin for treatment of diarrhea-predominant irritable bowel syndrome.  PMID: 29897844
  • New concepts on intestinal microbiota and the role of the non-absorbable antibiotics with special reference to in digestive diseases.  PMID: 29807873
  • Effects of on Central Responses to Social Stress-a Pilot Experiment.  PMID: 29713909
  • Rifaxmin is associated with modest, transient decreases in multiple taxa in the gut microbiota of patients with diarrhoea-predominant irritable bowel syndrome.  PMID: 29708822
  • Reduces Markers of Inflammation and Bacterial 16S rRNA in Zambian Adults with Hepatosplenic Schistosomiasis: A Randomized Control Trial.  PMID: 29436337
  • Lack of Development of Opportunistic Infections, Including Candidiasis, in Patients with Diarrhea-Predominant IBS Receiving Repeat Treatment with Rifaximin
  • CHARACTERIZATION OF LONG-TERM RIFAXIMIN RESPONDERS FROM A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED REPEAT TREATMENT TRIAL FOR DIARRHEA-PREDOMINANT IRRITABLE BOWEL SYNDROME (IBS-D)
  • EFFICACY OF RIFAXIMIN ON BLOATING IN PATIENTS WITH DIARRHEA–PREDOMINANT IRRITABLE BOWEL SYNDROME (IBS–D): A POOLED ANALYSIS OF THREE PHASE 3, RANDOMIZED, PLACEBO–CONTROLLED TRIALS
  • EFFICACY OF RIFAXIMIN IN PATIENTS WITH DIARRHEA-PREDOMINANT IRRITABLE BOWEL SYNDROME (IBS-D) AND PRIOR USE OF IBS MEDICATIONS
  • Rifaximin Repeat Treatment for Diarrhea-Predominant IBS and Impact on Clostridium Difficile Infection Development
  • Review article: an analysis of safety profiles of the treatments for diarrhoea-predominant irritable bowel syndrome.  PMID: 30194692
  • The role of small intestinal bacterial overgrowth in cystic fibrosis: a randomized case-controlled clinical trial with rifaximin.  PMID: 30232597
  • Fecal Microbiota Alterations Associated With Diarrhea-Predominant Irritable Bowel Syndrome.  PMID: 30090090
  • No effect of rifaximin on soluble CD163, mannose receptor or type III and IV neoepitope collagen markers in decompensated cirrhosis: Results from a randomized, placebo controlled trial.  PMID: 30183743
  • Rifaximin anti-inflammatory activity on bovine endometrium primary cell cultures: a preliminary study.  PMID: 29984902
  • A randomized double-blind placebo-controlled trial showing to improve constipation by reducing methane production and accelerating colon transit: A pilot study.  PMID: 30406392
  • Double-Blind Placebo-Controlled Study of and Lactulose Hydrogen Breath Test in Gulf War Veterans with Irritable Bowel Syndrome.  PMID: 30370492
  • Declining Rates of Referral for Irritable Bowel Syndrome Without Constipation at a Tertiary Care Center.  PMID: 30324554
  • Changes in Fecal Calprotectin After Rifaximin Treatment in Patients With Nonconstipated Irritable Syndrome.  PMID: 30611316
  
   Probiotics
  • Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth.  PMID: 29508268
  • Effect of Bifidobacterium infantis 35624 (Align) on the Lactulose Breath Test for Small Intestinal Bacterial Overgrowth.  PMID: 29397491
  • ​Is It Useful to Administer Probiotics Together With Proton Pump Inhibitors in Children With Gastroesophageal Reflux?  PMID: 29291607 
  • A randomized placebo-controlled clinical trial of a multi-strain probiotic formulation (Bio-Kult®) in the management of diarrhea-predominant irritable bowel syndrome.  PMID: 29801486
  • Bifidobacterium infantis M-63 improves mental health in victims with irritable bowel syndrome developed after a major flood disaster.  PMID: 30525951
  • Combining probiotics and an angiotensin-II type 1 receptor blocker has beneficial effects on hepatic fibrogenesis in a rat model of non-alcoholic steatohepatitis.  PMID: 30365236

   Prokinetics
  • Manometric evaluation of the motilin receptor agonist camicinal (GSK962040) in humans.  PMID: 28782145
  • Nonclinical Cardiovascular Studies of Prucalopride, a Highly Selective 5-Hydroxytryptamine 4 Receptor Agonist.  PMID: 29180358
  • Risk of small intestinal bacterial overgrowth in patients receiving proton pump inhibitors versus proton pump inhibitors plus prokinetics: Small intestinal bacterial overgrowth.  DOI: 10.1002/jgh3.12045
  • Ginger (Zingiber officinale Roscoe) for the treatment and prevention of necrotizing enterocolitis.  PMID: 30005955  (Beneficial intestinal effects of common used SIBO prokinetic ginger)
 
   FMT
  • FECAL TRANSPLANTS FILTERED TO REMOVE BACTERIA REDUCE INTESTINAL BACTERIAL DENSITY IN MOUSE RECIPIENTS
  
   Diet
  • Use of Dietary Management in Irritable Bowel Syndrome: Results of a Survey of over 1500 United States Gastroenterologists.  PMID: 29886578
  • EXCLUSION DIETS AND IRRITABLE BOWEL SYMPTOMS: A SYSTEMATIC REVIEW AND META-ANALYSIS
  • Influence of Dietary Restriction on Irritable Bowel Syndrome.  PMID: 30315281
  • Gluten-Free Diet and Its 'Cousins' in Irritable Bowel Syndrome.  PMID: 30423854
  • Breaking bread!  PMID: 30322423 

   Diet: Low FODMAP Diet
  • Low-FODMAP vs regular rye bread in irritable bowel syndrome: Randomized SmartPill™ study.  PMID: 29568206
  • Low FODMAP Diet for IBS.  PMID: 29526727
  • Adherence to a Low FODMAP Diet in Relation to Symptoms of Irritable Bowel Syndrome in Iranian Adults.  PMID: 29497906
  • Fermentable short chain carbohydrate (FODMAP) content of common plant-based foods and processed foods suitable for vegetarian- and vegan-based eating patterns.  29473657
  • Radiation-induced enteropathy - how a low-FODMAP diet might help.  PMID: 29433349
  • The low FODMAP diet in the management of irritable bowel syndrome: an evidence-based review of FODMAP restriction, reintroduction and personalisation in clinical practice.  PMID: 29336079
  • Letter: irritable bowel syndrome-how a low-FODMAP diet or yoga might help.  PMID: 29314135
  • Letter: irritable bowel syndrome-how a low-FODMAP diet or yoga might help. Authors' reply.  PMID: 29314128
  • Exploring Gut Microbiota Composition as an Indicator of Clinical Response to Dietary FODMAP Restriction in Patients with Irritable Bowel Syndrome.  PMID: 29302878
  • FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction.  PMID: 29202473
  • Effects of Prebiotics vs a Diet Low in Fodmaps in Patients with Functional Gut Disorder.  PMID: 29964041
  • COOL Use of Sourdough in Low FODMAP Baking.  PMID: 29932101
  • Dietary Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols (FODMAPs) and Gastrointestinal Disease.  PMID: 29870082
  • [Diet low in fermentable oligosaccharides, disaccharides, monosaccharides and polyols, and quality of life in patients with irritable bowel syndrome in Colombia].  PMID: 29809329
  • The role of diet in the management of irritable bowel syndrome: a focus on FODMAPs.  PMID: 29764234
  • Applying a Low-FODMAP Dietary Intervention to a Female Ultra-Endurance Runner With Irritable Bowel Syndrome During a Multi-Stage Ultra-Marathon.  PMID: 29757053
  • Evaluation of FODMAP Carbohydrates Content in Selected Foods in the United States.  PMID: 29706489
  • A Pilot Study of the Effect of Green Kiwifruit on Human Intestinal Fermentation Measured by Hydrogen and Methane Breath Testing.  PMID: 29694795
  • [Implementationof a low FODMAP dietforfunctional abdominal pain].  PMID: 29685830
  • Low fermentable oligo-di-mono-saccharides and polyols diet versus general dietary advice in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trial.  PMID: 29159993  
  • AN ADAPTED LOW FODMAP DIET IS SAFE AND EFFECTIVE ALSO IN THE LONG TERM
  • THE IMPACT OF HIGH VS. LOW FODMAP DIET ON GI SYMPTOMS AND BREATH HYDROGEN & METHANE EXCRETION IN THAI HEALTHY VOLUNTEERS AND SUBJECTS WITH FUNCTIONAL BLOATING
  • REDUCING FODMAP CONTENT IN THE BREASTFEEDING MOTHER’S DIET ALLEVIATES THE SYMPTOMS OF INFANTILE COLIC: A RANDOMISED CONTROLLED DOUBLE-BLIND CROSSOVER FEEDING STUDY
  • GUT MICROBIOTA-DIET INTERACTIONS IN A HUMANIZED MOUSE MODEL OF IBS: THE ROLE OF INTESTINAL MAST CELLS
  • GUT MICROBIOTA DEFINES HOST RESPONSES TO DIETARY FERMENTABLE CARBOHYDRATES IN IBS: THE ROLE OF BACTERIAL HISTAMINE
  • Clinical application of dietary therapies in irritable bowel syndrome.  PMID: 30240475
  • Applicability of Yeast Fermentation to Reduce Fructans and Other FODMAPs.  PMID: 30200589
  • The Role of a Low Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyol Diet in Nonceliac Gluten Sensitivity.  PMID: 30158962
  • Outcome of hospital outpatient treatment of functional gastrointestinal disorders.  PMID: 30091176
  • Is a low FODMAP diet dangerous?  PMID: 30083779
  • A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects.  PMID: 30048547
  • A Systematic Review and Meta-Analysis Evaluating the Efficacy of a Gluten-Free Diet and a Low FODMAPs Diet in Treating Symptoms of Irritable Bowel Syndrome.  PMID: 30046155
  • Use of Dietary Management in Irritable Bowel Syndrome: Results of a Survey of Over 1500 United States Gastroenterologists.  PMID: 29886578
  • Dietary exclusion of fructose and lactose after positive breath tests improved rapid-transit constipation in children.  PMID: 30619935
  • The efficacy of dietary intervention on gastrointestinal involvement in systemic sclerosis: A systematic literature review.  PMID: 30612705
  • Limiting consumption for patients with IBS.  PMID: 30601785
  • Prebiotics Versus Low Diet: An Interpretative Nightmare.  PMID: 30543795
  • Early experience with a low diet in Asian patients with irritable bowel syndrome.  PMID: 30483586
  • Gluten-free and low- sourdoughs for patients with coeliac disease and irritable bowel syndrome: A clinical perspective.  PMID: 30388591
  • Low FODMAP Diet: What Your Patients Need to Know.  PMID: 30356177
  • Use of dietary interventions for functional gastrointestinal disorders.  PMID: 30308416
  • COOL Kluyveromyces marxianus yeast enables the production of low FODMAP whole wheat breads.  PMID: 30166134
Herbal Antibiotics
  • Zengye decoction induces alterations to metabolically active gut microbiota in aged constipated rats.  PMID: 30551387


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