2022 Research Articles

Overview

• Small Intestinal Bacterial Overgrowth.  PMID: 31536241

Causes/ Risk Factors  
  Food/Water Poisoning

• Campylobacter infection and the link with Irritable Bowel Syndrome: on the pathway towards a causal association.  PMID: 35134916  Results: “In rodent models, Campylobacter jejuni 81-176 can cause loose stool months after the infection is cleared, and share common pathophysiology as IBS patients, such as elevated intestinal TLR-4 and IL-8, antibodies to CdtB and vinculin, increased intraepithelial lymphocytes, and small intestinal bacterial overgrowth.”

   Surgery 

• The Effects of One Anastomosis Gastric Bypass Surgery on the Gastrointestinal Tract  PMID: 35057486

Associated Conditions
 Children

• Role of Glucose Breath Test for Small Intestinal Bacterial Overgrowth in Children and Adolescents With Functional Abdominal Pain Disorders in Korea.  PMID: 34980690
• Bacterial overgrowth assessment and treatment among pediatric intestinal rehabilitation & nutrition support providers: an international survey of clinical practice patterns.  PMID: 35274342

   Chronic Intestinal Pseudo-Obstruction

• Chronic Intestinal Pseudo-Obstruction Is Associated with Intestinal Methanogen Overgrowth.   PMID: 35001241

   Hypothyroid

• Association of Differential Metabolites With Small Intestinal Microflora and Maternal Outcomes in Subclinical Hypothyroidism During Pregnancy  PMID: 35071037

   IBD

• Small intestinal bacterial overgrowth in inflammatory bowel disease.  PMID: 35031976

   IBS

• A systematic review and meta-analysis on the prevalence of non-malignant, organic gastrointestinal disorders misdiagnosed as irritable bowel syndrome  PMID: 35121775

   Liver Disease

• Hydrogen-producing small intestinal bacterial overgrowth is associated with hepatic encephalopathy and liver function  PMID: 35213654

  Parkinson’s disease

• Parkinson's Disease Medication Alters Small Intestinal Motility and Microbiota Composition in Healthy Rats.  PMID: 35076270

Testing
  Breath Testing

• Small Intestinal Bacterial Overgrowth Breath Testing in Gastroenterology: Clinical Utility and Pitfalls DOI 10.1016/j.cgh.2022.02.031
• A Single Fasting Exhaled Methane Level Correlates With Fecal Methanogen Load, Clinical Symptoms and Accurately Detects Intestinal Methanogen Overgrowth.  PMID: 35041624

  Other

• Development and validation of a novel scoring system for bloating and distension: The Mayo Bloating Questionnaire.  PMID: 35202489

Methane

• Chronic Intestinal Pseudo-Obstruction Is Associated with Intestinal Methanogen Overgrowth.   PMID: 35001241

Treatment
  Antibiotics

• Rifaximin.  PMID: 32966000
• Kinetics of bactericidal potency with synergistic combination of allicin and selected antibiotics.  PMID: 35339353

           Commentary: Rifaximin and other antibiotics were tested against e coli, in combination with allicin, to see if 
           the combination was more effective than single antibiotics. Rifaximin and Allicin are standard SIBO antibiotics and e coli is
           one of the main overgrown bacteria in hydrogen-SIBO. "...the highest killing effect was observed with rifaximin-allicin
           combination.”  
  Prokinetics 

• Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating.  PMID: 34585675

   Diet: FODMAP

• Long-Term Effects of a Web-Based Low-FODMAP Diet Versus Probiotic Treatment for Irritable Bowel Syndrome, Including Shotgun Analyses of Microbiota: Randomized, Double-Crossover Clinical Trial  PMID: 34904950
• Fermentable oligo-, di-, monosaccharides, and polyols (FODMAPs), but not gluten, elicit modest symptoms of irritable bowel syndrome: a double-blind, placebo-controlled, randomized three-way crossover trial  PMID: 34617561
• Predictors of Symptom-Specific Treatment Response to Dietary Interventions in Irritable Bowel Syndrome  PMID: 35057578\
• How to manage irritable bowel syndrome in children  PMID: 34525233
• Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome  PMID: 35125827
• Review article: current and future treatment approaches for pain in IBS  PMID: 34927753
• FODMAPs or gluten as inducers of symptoms in irritable bowel syndrome: separating the wheat from the chaff  PMID: 34910099
• Long-term personalized low FODMAP diet in IBS.  PMID: 35293089