2017 Research Articles

OVERVIEW

• Small Intestinal Bacterial Overgrowth and Other Intestinal Disorders.  PMID: 28164845
• Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy.  PMID: 28274108
• Take-Aways from the 2017 Integrative SIBO Conference, Practice Update from the Speakers 

UNDERLYING CAUSES

• Reduced interstitial cells of Cajal and increased intraepithelial lymphocytes are associated with development of small intestinal bacterial overgrowth in post-infectious IBS mouse model.  PMID: 28679338
• A Prospective Evaluation of Ileocecal Valve Dysfunction and Intestinal Motility Derangements in Small Intestinal Bacterial Overgrowth.  PMID: 28871499

PATHOPHYSIOLOGY

• Coliform and Upper Respiratory Tract Bacterial Overgrowth of the Small Intestines are Distinct Entities with Unique Risk Factors 
• Jejunal Flora of Patients with Small Intestinal Bacterial Overgrowth: DNA Sequencing Provides no Evidence for a Migration of Colonic Microbes
• Small Intestinal Bacterial Overgrowth Accelerates Transit in Mice

CAUSES/RISK FACTORS
   Overview

• Small Bowel Bacterial Overgrowth (SIBO) in Individuals without and with Risk Factors 

   Burn Injury (with alcohol intoxication)

• Interleukin-22 Prevents Microbial Dysbiosis and Promotes Intestinal Barrier Regeneration Following Acute Injury.  PMID: 28498296

  Diseases

• Small-Intestinal Bacterial Overgrowth is Associated With Concurrent Intestinal Inflammation But Not With Systemic Inflammation in Crohn's Disease Patients. PMID: 28134633
• Malabsorption, Orocecal Transit Time and Small Intestinal Bacterial Overgrowth in Type 2 Diabetic Patients: A Connection. PMID: 28149017

• Serial Frozen Fecal Microbiota Transplantation in the Treatment of Chronic Intestinal Pseudo-obstruction: A Preliminary Study. PMID: 27840368
• [Specific features of impaired intestinal digestion, absorption, and microbiocenosis in patients with cholelithiasis]. Russian.  PMID: 28281512
• Intestinal alkaline phosphatase deficiency leads to dysbiosis and bacterial translocation in the newborn intestine.  PMID: 28985873
• Are the estrogenic hormonal effects of environmental toxins affecting small intestinal bacterial and microfilaria overgrowth?  PMID: 29150304
• Review article: the gut microbiome as a therapeutic target in the pathogenesis and treatment of chronic liver disease.  PMID: 29083037

   Food/Water Poisoning

• Autoimmunity as a Potential Cause of Post-Infectious Gut Dysmotility: A Longitudinal Observation.  PMID: 28381845
• Assessment of Anti-vinculin and Anti-cytolethal Distending Toxin B Antibodies in Subtypes of Irritable Bowel Syndrome.  PMID: 28451914
• Reduced interstitial cells of Cajal and increased intraepithelial lymphocytes are associated with development of small intestinal bacterial overgrowth in post-infectious IBS mouse model.  PMID: 28679338
• Antibodies to Vinculin and Cytolethal Distending Toxin B (IBSchek) are Associated with a Post-Infectious Aetiology in Patients with Mixed Bowel Habit IBS but not Small Intestinal Bacterial Overgrowth, Quality of Life or Changes in Gastrointestinal Motility   
• Cytolethal Distending Toxin B (CdtB) Exposure Alone is Sufficient to Precipitate Autoimmunity and Changes to the Small Intestinal Microbiome in a Rat Model of Post-Infectious IBS
• Rifaximin fails to prevent campylobacteriosis in the human challenge model: a randomized, double-blind, placebo-controlled trial.  PMID: 29145631
• Exposure to environmental microbiota explains persistent abdominal pain and irritable bowel syndrome after a major flood.  PMID: 29255490

    PPI's/Hypochlorhydria 

• Hunger and microbiology: is a low gastric acid-induced bacterial overgrowth in the small intestine a contributor to malnutrition in developing countries?  PMID: 28714103
• Meta-analysis: proton pump inhibitors moderately increase the risk of small intestinal bacterial overgrowth.  PMID: 28770351
• A Randomized Controlled Trial of Proton Pump Inhibitors in the Treatment of Acute Pancreatitis Patients: The Benefits and Harms
• Long-term proton pump inhibitor therapy leads to small bowel bacterial overgrowth as determined by breath hydrogen and methane excretion.  PMID: 29182524
• Adverse events of proton pump inhibitors: potential mechanisms.  PMID: 29219052
• The association of proton pump inhibitor therapy and small bowel bacterial overgrowth in children.  PMID: 28800034

   Surgery 

• Great New Study! Positive Glucose Breath Tests in Patients with Hysterectomy, Gastrectomy, and Cholecystectomy. PMID: 27965476
• Pancreatic enzyme replacement therapy after gastric resection: An update.  PMID: 29170072
• The gut-liver axis: impact of a mouse model of small-bowel bacterial overgrowth.  PMID: 29229136

  Weight

• Obesity increases the risk of small intestinal bacterial overgrowth (SIBO).  PMID: 28940740

ASSOCIATED CONDITIONS
   Acute Pancreatitis

• A Randomized Controlled Trial of Proton Pump Inhibitors in the Treatment of Acute Pancreatitis Patients: The Benefits and Harms

   Anemia

• Fecal microbiota analysis of children with small intestinal bacterial overgrowth among residents of an urban slum in Brazil.  PMID: 29049893

   Anxiety

• Exposure to environmental microbiota explains persistent abdominal pain and irritable bowel syndrome after a major flood.  PMID: 29255490

   Autism 

• Hydrogen breath test to detect small intestinal bacterial overgrowth: a prevalence case-control study in autism.

   Carbohydrate Malabsorption

• Small Intestinal Bacterial Overgrowth May Increase the Likelihood of Lactose and Sorbitol but not Fructose Intolerance False Positive Diagnosis. PMID: 28801371
• Prevalence of abnormal lactose breath hydrogen tests in children with functional abdominal pain.  PMID: 28589304

   Celiac

• Small intestinal bacterial overgrowth and celiac disease: A systematic review with pooled-data analysis.  PMID: 28191721
• Celiac Disease and Gluten Sensitivity.  PMID: 29132529

   Children

• New insights into the fecal microbiota of children living in a slum: association with small bowel bacterial overgrowth.  PMID: 29274895
• The association of proton pump inhibitor therapy and small bowel bacterial overgrowth in children.  PMID: 28800034
• Fecal microbiota analysis of children with small intestinal bacterial overgrowth among residents of an urban slum in Brazil.  PMID: 29049893

   Cholelithiasis (gallstones)

• [Specific features of impaired intestinal digestion, absorption, and microbiocenosis in patients with cholelithiasis]. Russian.  PMID: 28281512
• The Association of Gallstone and Cholecystectomy with Metabolic Syndrome, Fatty Liver, and Small Intestinal Bacterial Overgrowth

   COPD NEW Associated Disease

• Increased Pulmonary CO2 Excretion in Patients with Small Intestinal Bacterial Overgrowth (SIBO): Possible Implications for COPD

   Coronary Artery Disease NEW Associated Disease

• Association Between Small Intestinal Bacterial Overgrowth by Glucose Breath Test and Coronary Artery Disease.  PMID: 29110161

   Cystic Fibrosis

• The Role of Small Intestinal Bacterial Overgrowth in Cystic Fibrosis: A Randomized Case-Controlled Clinical Trial with Rifaximin

   Diabetes

• Malabsorption, Orocecal Transit Time and Small Intestinal Bacterial Overgrowth in Type 2 Diabetic Patients: A Connection.  PMID: 28149017
• Diabetes and the Small Intestine.  PMID: 28913777

   Gastroparesis

• Delayed Gastric Emptying is Associated with Coliform Small Intestinal Bacterial Overgrowth based on Direct Luminal Aspiration from the Proximal Jejunum

   H Pylori

• Functional 13C-urea and glucose hydrogen/methane breath tests reveal significant association of small intestinal bacterial overgrowth in individuals with active Helicobacter pylori infection. PMID: 27586816

   IBD (Inflammatory Bowel Disease)

• Small-Intestinal Bacterial Overgrowth is Associated With Concurrent Intestinal Inflammation But Not With Systemic Inflammation in Crohn's Disease Patients. PMID: 28134633

   IBS (Irritable Bowel Syndrome)

• Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy.  PMID: 28274108
• Small intestinal bacterial overgrowth as a cause for irritable bowel syndrome: guilty or not guilty? PMID: 28257307
• Rifaximin (Xifaxan) for Irritable Bowel Syndrome. PMID: 28290635
• New insights in IBS-like disorders: Pandora's box has been opened; a review.  PMID: 28702130
• [The dietary features of diarrhea predominant irritable bowel syndrome patients with small intestinal bowel overgrowth]. Chinese.  PMID: 28789488
• The relationship between small intestinal bacterial overgrowth and irritable bowel syndrome.  PMID: 29228433

   Intestinal Bechet's NEW Associated Disease

• Rediscover the clinical value of small intestinal bacterial overgrowth in patients with intestinal Behçet's disease.  PMID: 28666309

   Intestinal Disorders

• Small Intestinal Bacterial Overgrowth and Other Intestinal Disorders. PMID: 28164845

   Liver Disease

• Urinary Metabolomics in Pediatric Obesity and NAFLD Identifies Metabolic Pathways/Metabolites Related to Dietary Habits and Gut-Liver Axis Perturbations.  PMID: 28492501
• Influence of gut microbiota on the development and progression of nonalcoholic steatohepatitis.PMID: 28875318
• Systematic Review and Meta-Analysis: Prevalence of Small Intestinal Bacterial Overgrowth in Chronic Liver Disease.  PMID: 29272899
• The gut-liver axis: impact of a mouse model of small-bowel bacterial overgrowth.  PMID: 29229136
• Low-grade small intestinal bacterial overgrowth is common in patients with non-alcoholic steatohepatitis on quantitative jejunal aspirate culture.  PMID: 29034439
• Liver disease symptoms in non-alcoholic fatty liver disease and small intestinal bacterial overgrowth.  PMID: 29101772

   Malnutrition

• Hunger and microbiology: is a low gastric acid-induced bacterial overgrowth in the small intestine a contributor to malnutrition in developing countries?  PMID: 28714103

   Microbiota

• Fecal microbiota analysis of children with small intestinal bacterial overgrowth among residents of an urban slum in Brazil.  PMID: 29049893
• New insights into the fecal microbiota of children living in a slum: association with small bowel bacterial overgrowth.  PMID: 29274895
• Exposure to environmental microbiota explains persistent abdominal pain and irritable bowel syndrome after a major flood.  PMID: 29255490

   Obesity

• Obesity Is Inversely Related to Hydrogen-Producing Small Intestinal Bacterial Overgrowth in Non-Constipation Irritable Bowel Syndrome.  PMID: 28480652

   Osteoporosis

• Osteoporosis/Osteopenia Bone mineral density in patients with small intestinal bacterial overgrowth, study 2. PMID: 14571751

   Pancreatic Disease

• Gut microbiota and pancreatic diseases.  PMID: 28240004
• Small intestine bacterial overgrowth in chronic pancreatitis.  DOI: 10.25121/PNM.2017.30.11.619

   Psoriasis

• Psoriasis and small intestine bacterial overgrowth.  PMID: 29057460 

   Rosacea

• Analysis to obtain hazard ratios (HRs) of the risk of new-onset CeD, CD, UC, HPI, SIBO and IBS in patients with rosacea. PMID: 27501017
• Effects of the treatment for small intestine bacterial overgrowth on rosacea.  PMID: 28782149
• Etiopathogenesis of rosacea: a prospective study with a three-year follow-up.  PMID: 26889725

   Short Bowel Syndrome

• Is Serum Methylmalonic Acid a Reliable Biomarker of Vitamin B12 Status in Children with Short   Bowel Syndrome: A Case Series.  PMID: 29129351

   Systemic Sclerosis

• Clinical correlates of faecal incontinence in systemic sclerosis: identifying therapeutic avenues. PMID: 28013205 
• The Gastrointestinal dysmotility and infections in Systemic Sclerosis- A real world scenario. PMID: 28443513

   Tropical Sprue

• Post-infectious IBS, tropical sprue and small intestinal bacterial overgrowth: the missing link.  PMID: 2851362

   Vitamin B12 Deficiency

• Is Serum Methylmalonic Acid a Reliable Biomarker of Vitamin B12 Status in Children with Short Bowel Syndrome: A Case Series.  PMID: 29129351

TESTING

• Hydrogen and Methane-Based Breath Testing in Gastrointestinal Disorders: The North American Consensus. PMID: 28323273 (Note: This article offers helpful guidance on breath testing from top Gastroenterologists. It's especially important because almost no aspects of breath testing are standardized.)
• Poor reproducibility of breath hydrogen testing: Implications for its application in functional bowel disorders.  PMID: 28344797
• Prevalence of Small Intestine Bacterial Overgrowth In Patients with Gastrointestinal Symptoms. PMID: 28273273
• The clinical value of breath hydrogen testing.  PMID: 28244675
• Assessment of Anti-vinculin and Anti-cytolethal Distending Toxin B Antibodies in Subtypes of Irritable Bowel Syndrome.  PMID: 28451914
• Selection of a cut-off for high- and low-methane producers using a spot-methane breath test: results from a large north American dataset of hydrogen, methane and carbon dioxide measurements in breath. PMID:  28130375  PDF
• Breath Hydrogen Testing in East and Southeast Asia.  PMID: 29035975
• Endoscopically Assisted Glucose Breath Test (EAGBT): A Novel Diagnostic Approach for Distal SIBO
• Initial Paradoxical Peaks on Breath Testing (First Sample High) do not Affect the Diagnostic Utility of the Spot methane Breath Test
• Measurement of Hydrogen Sulfide during Breath Testing Correlates to Patient Symptoms 
• Are Breath Tests Helpful in Predicting the Response to a Low-Fodmap Diet in Patients with Functional Gastrointestinal Disorders?
• At What Price Accuracy are IBS-D Biomarkers Cost-Saving in Clinical Practice?
• Small Intestinal Bacterial Overgrowth: Should Screening Be Included in the Pre-fecal Microbiota Transplantation Evaluation?  PMID: 29188472

METHANE

• Assessing the colonic microbiome, hydrogenogenic and hydrogenotrophic genes, transit and breath methane in constipation.  PMID: 28295896
• Elevated Methane Levels in Small Intestinal Bacterial Overgrowth Suggests Delayed Small Bowel and Colonic Transit 
• Gut Colonization by Methanogenic Archaea Is Associated with Organic Dairy Consumption in Children. PMID: 28344572
• Methanogenic Flora and its Effects on Regional and Whole Gut Transit and Small Bowel PH
• The Effect of Methane on Calcium Signaling of Ileal Smooth Muscle of Guinea Pig

HYDROGEN SULFIDE

• Measurement of Hydrogen Sulfide during Breath Testing Correlates to Patient Symptoms 

TREATMENT

• Are the estrogenic hormonal effects of environmental toxins affecting small intestinal bacterial and microfilaria overgrowth?  PMID: 29150304

   Herbal Antibiotics

• Integrative Treatment of Chronic Abdominal Bloating and Pain Associated With Overgrowth of Small Intestinal Bacteria: A Case Report.  PMID: 28646815
• The Efficacy and Potential Mechanisms of Chinese Herbal Medicine on Irritable Bowel Syndrome. PMID: 28828984

   Antibiotics

• Efficacy of antibiotherapy for treating flatus incontinence associated with small intestinal bacterial overgrowth: A pilot randomized trial.  PMID:28763464

   Antibiotics: Rifaximin

• Rifaximin’s safe and effective for the treatment of small intestine bacterial overgrowth. PMID: 28078798
• Systematic review with meta-analysis: rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth.  PMID: 28078798
• Rifaximin in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome. PMID: 28376323
• Rifaximin (Xifaxan) for Irritable Bowel Syndrome. PMID: 28290635
• Repeat Rifaximin for Irritable Bowel Syndrome: No Clinically Significant Changes in Stool Microbial Antibiotic Sensitivity.  PMID:28589238
• Rifaximin exerts beneficial effects in PI-IBS mouse model beyond gut microbiota.  PMID:28573746
• Eubiotic properties of rifaximin: Disruption of the traditional concepts in gut microbiota modulation.  PMID: 28740337
• Rifaximin Re-treatment in Patients with Irritable Bowel Syndrome: Feels Like the First Time?  PMID: 28646286
• Characterization of Abdominal Pain in Patients with Diarrhea-Predominate IBS Treated with Rifaximin 
• Sustained Response and Predictors of Sustained Response in Patients who Respond to Multiple Courses of Rifaximin for Diarrhea-Predominant Irritable Bowel Syndrome
• Impact of Rifaximin on Health-Related Quality of Life in Patients with Diarrhea-Predominant Irritable Bowel Syndrome
• How Cost Affects the Treatment Choice for Irritable Bowel Syndrome with Diarrhea Patients: A Cost-Effectiveness Analysis of Tricyclic Agents and Rifaximin

   Methane

• Ginkgo fruit extract as an additive to modify rumen microbiota and fermentation and to mitigate methane production. PMID: 28088403
• Development of a Modified-Release Formulation of Lovastatin Targeted to Intestinal Methanogens Implicated in Irritable Bowel Syndrome With Constipation.  PMID: 28989013
• Effect of Lactobacillus reuteri (DSM 17938) on methane production in patients affected by functional constipation: a retrospective study. PMID: 28429333   

   FMT (Fecal Microbiotia Transplanation)

• Serial Frozen Fecal Microbiota Transplantation in the Treatment of Chronic Intestinal Pseudo-obstruction: A Preliminary Study. PMID: 27840368
• Small Intestinal Bacterial Overgrowth: Should Screening Be Included in the Pre-fecal Microbiota Transplantation Evaluation?  PMID: 29188472
• Faecal microbiota transplantation in patients with Clostridium difficile and significant comorbidities as well as in patients with new indications: A case series.  PMID: 29093626

   Probiotics

• Probiotics for Preventing and Treating Small Intestinal Bacterial Overgrowth: A Meta-Analysis and Systematic Review of Current Evidence. PMID: 28267052
• Lactobacillus casei DG and its postbiotic reduce the inflammatory mucosal response: an ex-vivo organ culture model of post-infectious irritable bowel syndrome. PMID: 28410580
• Effect of Lactobacillus reuteri (DSM 17938) on methane production in patients affected by functional constipation: a retrospective study. PMID: 28429333
• Aciduric Strains of Lactobacillus reuteri and Lactobacillus rhamnosus, Isolated from Human Feces, Have Strong Adhesion and Aggregation Properties.  PMID: 28756502
• Probiotics for Gastrointestinal Conditions: A Summary of the Evidence.  PMID: 28762696
• Successful Use of Probiotic VSL#3 for Treatment of Small Bowel Bacterial Overgrowth Symptoms in Pediatric Patients with Intestinal Failure

   Diet

• Pilot Study: Comparison of Sourdough Wheat Bread and Yeast-Fermented Wheat Bread in Individuals with Wheat Sensitivity and Irritable Bowel Syndrome.  PMID: 29113045

   Diet: Low FODMAP Diet

• The use of smartphone health apps and other mobile health (mHealth) technologies in dietetic practice: a three country study. The top two nutrition apps recommended were MyFitnessPal® (62%) and the Monash University Low FODMAP Diet® (44%). PMID: 28116773
• Irritable bowel syndrome and diet. PMID: 28110300
• Multivariate modelling of faecal bacterial profiles of patients with IBS predicts responsiveness to a diet low in FODMAPs.  PMID: 28416515
• Low FODMAP in 2017: Lessons learned from clinical trials and mechanistic studies. PMID: 28345807
• White Grape Juice Elicits a Lower Breath Hydrogen Response Compared with Apple Juice in Healthy Human Subjects: A Randomized Controlled Trial. PMID: 28342683
• The Low FODMAP Diet: Many Question Marks for a Catchy Acronym. PMID: 28300773
• Adapting the low FODMAP diet to special populations: infants and children. PMID: 28244674
• History of the low FODMAP diet. PMID: 28244673
• The low-FODMAP diet in the management of functional dyspepsia in East and Southeast Asia. PMID: 28244670
• How to institute the low-FODMAP diet. PMID: 28244669
• The evidence base for efficacy of the low FODMAP diet in irritable bowel syndrome: is it ready for prime time as a first-line therapy? PMID: 28244668
• When the low FODMAP diet does not work. PMID: 28244666
• FODMAPs: food composition, defining cutoff values and international application. PMID: 28244665
• Re-challenging FODMAPs: the low FODMAP diet phase two. PMID: 28244664
• How do FODMAPs work? PMID: 28244663
• Who should deliver the low FODMAP diet and what educational methods are optimal: a review. PMID: 28244661
• Editorial: rethinking predictors of response to the low FODMAP diet - should we retire fructose and lactose breath-hydrogen testing and concentrate on visceral hypersensitivity? Authors' reply. PMID: 28370046
• Dietary and pharmacological treatment of abdominal pain in IBS. PMID: 28232472
• Effects of varying dietary content of fermentable short-chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome. PMID: 27747984
  
• The low FODMAP diet: fundamental therapy in the management of irritable bowel syndrome. PMID: 28617710
• Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: A Meta-Analysis. PMID: 28846594
• The low FODMAP diet: recent advances in understanding its mechanisms and efficacy in IBS. PMID: 28592442
• Easing Concerns About the Low FODMAP Diet in Patients With Irritable Bowel Syndrome  PMID: 28867269
• Controversies and Recent Developments of the Low-FODMAP Diet  PMID: 28420945
• Low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet improves symptoms in adults suffering from irritable bowel syndrome (IBS) compared to standard IBS diet: A meta-analysis of clinical studies.  PMID: 28806407
  
• Effect of intragastric FODMAP infusion on upper gastrointestinal motility, gastrointestinal, and psychological symptoms in irritable bowel syndrome vs healthy controls. PMID: 28762592
• Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment. PMID: 28809383   
• Saccharomyces cerevisiae and Kluyveromyces marxianus co-cultures allow to reduce FODMAP levels in whole wheat bread. PMID: 28869377
• Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease.  PMID:28566897
• Bioelectrical impedance vector analysis in patients with irritable bowel syndrome on a low FODMAPdiet: a pilot study.  PMID:28567692
• Gastrointestinal tolerance of low FODMAP oral nutrition supplements in healthy human subjects: a randomized controlled trial.  PMID:28545589
• Fermentable carbohydrates (FODMAPs) exacerbate functional gastrointestinal symptoms in patients with inflammatory bowel disease: a randomised, double-blind, placebo-controlled, cross-over, re-challenge trial.  PMID:28525543
• Systematic review: quality of trials on the symptomatic effects of the low FODMAP diet for irritable bowel syndrome.  PMID:28440580
• Whats 'App-ening': the help of new technologies in nutrition in digestive diseases.  PMID:28768297
• Clinical Response to the Low Fodmap Diet at 12 Months: A Prospective Evaluation of Patients with Irritable Bowel Syndrome
• Fructans Exacerbate Childhood Irritable Bowel Syndrome Symptoms 
• Are Breath Tests Helpful in Predicting the Response to a Low-Fodmap Diet in Patients with Functional Gastrointestinal Disorders?
• Microbial DNA Markers Associated with Response to a Low Fodmap Diet in Patients with Irritable Bowel Syndrome
• Volatile Organic Compounds Predict Response to Both Low Fodmap Diet and Probiotics in Irritable Bowel Syndrome: A Randomised Controlled Trial
• Association Between Prevalence of Fodmap Intolerance According to Nutrient Challenge Testing and IBS Subtypes
• High Fodmap Food in the Everyday Habitual Diet is Associated with Abdominal Symptoms in Patients with Irritable Bowel Syndrome 
• IBS Patients' Beliefs on Food-Related Symptoms are Not Reliable and Maintain a High Fodmap Diet and Symptoms
• Tryptophan Hydroxlase 1 (TPH1) Promotoer Genotype But Not Serum Serotonin Levels Identify IBS-D Patients More Likely to Benefit form the Low LOW FODMAP Diet
  
• Serum 7C4 Levels Decrease after low Fodmap Diet in IBS Patients: A Potential Mechanism for Benefit
• The Low Fodmap Diet is Equally Efficacious in IBS-D Patients with and Without Baseline Anxiety: A post-hoc Analysis from a US Randomized, Controlled Trial
  
• Oral α-Galactosidase Improves Gastrointestinal Toleance to a Diet High in Galacto-oligosaccharides: Adjunct Therapy to a Low FODMAP Diet in Irritable Bowel Syndrome
• Diet-Microbiota Interactions Underlie Symptoms' Generation in IBS
• Nutritional Habits and FODMAPs in Relation to Gastrointestinal Issues of Endurance Athletes
• FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial.  PMID: 26976734
• Fructans Exacerbate Symptoms in a Subset of Children With Irritable Bowel Syndrome.  PMID: 28970147
• FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction.  PMID: 29202473
• Non-celiac gluten sensitivity: people without celiac disease avoiding gluten-is it due to histamine intolerance?  PMID: 29181545
• Low FODMAPs diet vs. general dietary advice improves clinical response in patients with diarrhea-predominant irritable bowel syndrome: a randomized controlled trial.  PMID: 29159993
• Nutrition in the management of gastrointestinal diseases and disorders: the evidence for the low FODMAP diet.  PMID: 29156449
  
• Does the low FODMAP diet improve symptoms of radiation-induced enteropathy? A pilot study.  PMID: 29113519
  
• Letter: low-FODMAP diet for exercise-induced gastrointestinal syndrome-Authors' reply.  PMID: 29052859
• Gastrointestinal Symptoms and FODMAP Intake of Aged-Care Residents from Christchurch, New Zealand.  PMID: 28961170
• Irritable bowel syndrome and diet: where are we in 2018?  PMID: 28872467
• A Diet Low in Fermentable Oligo-, Di-, and Monosaccharides and Polyols Improves Quality of Life and Reduces Activity Impairment in Patients With Irritable Bowel Syndrome and Diarrhea.  PMID: 28668539
• Effect of diet and individual dietary guidance on gastrointestinal endocrine cells in patients with irritable bowel syndrome (Review).  PMID: 28849091
• Long-term impact of the low-FODMAP diet on gastrointestinal symptoms, dietary intake, patient acceptability, and healthcare utilization in irritable bowel syndrome.  PMID: 28707437
  
• A Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and A Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial.  PMID: 28625832
• Randomised clinical trial: yoga vs a low-FODMAP diet in patients with irritable bowel syndrome.  PMID: 29076171
  
• Low FODMAP: A Preliminary Strategy to Reduce Gastrointestinal Distress in Athletes.  PMID: 28891824
  
• Low fermentable, oligo-, di-, mono-saccharides and polyol diet in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.  PMID: 29129233
  

   

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