SIBO - Small Intestinal Bacterial Overgrowth
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2016 Research Articles


Causes/Risk Factors
  • Small Intestine Bacterial Overgrowth and Environmental Enteropathy in Bangladeshi Children.  PMID: 26758185
  • The Effects of Total Colectomy on Bacterial Translocation in a Model of Acute Pancreatitis.  PMID: 26730036
  • Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling.  PMID: 26660537
  • Prevalence and treatment of small intestinal bacterial overgrowth in postoperative patients with colorectal cancer.  PMID: 27123301
  • High risk of post-infectious irritable bowel syndrome in patients with Clostridium difficile infection.  PMID: 27444134
  • Functional 13C-urea and glucose hydrogen/methane breath tests reveal significant association of small intestinal bacterial overgrowth in individuals with active Helicobacter pylori infection. PMID: 27586816
  • Risk of small intestinal bacterial overgrowth with chronic use of proton pump inhibitors in children. PMID: 28030512
  • Small intestinal bacterial overgrowth is associated with irritable bowel syndrome and is independent of proton pump inhibitor usage.  PMID: 7402085

Associated Conditions
  • Association between small intestinal bacterial overgrowth and deep vein thrombosis.  PMID: 27044499
  • Etiopathogenesis of rosacea: a prospective study with a three-year follow-up.  PMID: 26889725
  • Rosacea and gastrointestinal disorders - a population-based cohort study. PMID: 27501017
  • Association between rosacea and gastrointestinal disorders. PMID: 27603953
  • Difficult case of Cronkhite-Canada syndrome with small intestinal bacterial overgrowth, Clostridium difficile infection and polymyalgia rheumatica.  PMID:26818813
  • Consequences of Small Intestinal Bacterial Overgrowth in Obese Patients Before and After Bariatric Surgery. PMID: 27576576
  • Macronutrient intakes in obese subjects with or without small intestinal bacterial overgrowth: an alimentary survey. PMID:
    26375876
  • Metabolic effects of eradicating breath methane using antibiotics in prediabetic subjects with obesity.  PMID: 26833719
  • Small intestinal bacterial overgrowth in adult patients with type 1 diabetes: its prevalence and relationship with metabolic control and the presence of chronic complications of the disease. PMID: 27535109
  • Higher visceral to subcutaneous fat ratio is associated with small intestinal bacterial overgrowth.  PMID: 27282099
  • Small Intestinal Bacterial Overgrowth in Patients with Refractory Functional Gastrointestinal Disorders. PMID:26554916
  • Streptomycin treatment alters the intestinal microbiome, pulmonary T cell profile and airway hyperresponsiveness in a cystic fibrosis mouse model.  PMID: 26754178
  • Identification and Treatment of New Inflammatory Triggers for Complex Regional Pain Syndrome: Small Intestinal Bacterial Overgrowth and Obstructive Sleep Apnea.  PMID: 26867023
  • The effect of small intestinal bacterial overgrowth on minimal hepatic encephalopathy in patients with cirrhosis.  PMID: 27279853
  • Gut microbiota and non-alcoholic fatty liver disease.  PMID: 26663004
  • Small intestinal bacterial overgrowth and toll-like receptor signaling in patients with non-alcoholic fatty liver disease.  PMID:
    26212089
  • Beneficial Effect of Synbiotic Supplementation on Hepatic Steatosis and Anthropometric Parameters, But Not on Gut Permeability in a Population with Nonalcoholic Steatohepatitis.  PMID: 27367724
  • Small Intestinal Bacterial Overgrowth Is Associated with Non-Alcoholic Fatty Liver Disease.  PMID: 27308646
  • Prevalence of Small Intestinal Bacterial Overgrowth among Chronic Pancreatitis Patients: A Case-Control Study.  PMID: 27446865
  • Systematic review and meta-analysis: Small intestinal bacterial overgrowth in chronic pancreatitis.  PMID: 27733912
  • Is irritable bowel syndrome an infectious disease?  PMID: 26819502
  • Small intestinal bacterial overgrowth is associated with irritable bowel syndrome and is independent of proton pump inhibitor usage.  PMID: 7402085
  • Small Intestinal Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: Clinical Characteristics, Psychological Factors, and Peripheral Cytokines.  PMID: 27379166
  • [Clinical features of irritable bowel syndrome with small intestinal bacterial overgrowth and a preliminary study of effectiveness of Rifaximin].  PMID: 27373356
  • Motility Evaluation in the Patient with Inflammatory Bowel Disease. PMID: 27633599
  • Is it bowel-associated dermatosis-arthritis syndrome induced by small intestinal bacteria overgrowth? PMID: 27652124
  • Ischemia/Reperfusion Injury Alters Sphingolipid Metabolism in the Gut. PMID: 27607915
  • Utility of wireless motility capsule and lactulose breath testing in the evaluation of patients with chronic functional bloating. PMID: 27648298
  • Clinical correlates of faecal incontinence in systemic sclerosis: identifying therapeutic avenues. PMID: 28013205
  • Prevalence of small intestinal bacterial overgrowth in Multiple Sclerosis: a case-control study from China. PMID: 27890460
  • Association between small intestinal bacterial overgrowth and deep vein thrombosis in patients with spinal cord injuries. PMID: 27930853
  • Clinical correlates of faecal incontinence in systemic sclerosis: identifying therapeutic avenues. PMID: 28013205
  • Prevalence of small intestinal bacterial overgrowth in Chinese patients with Parkinson's disease. PMID: 27589873

Testing
  • Breath Testing for Small Intestinal Bacterial Overgrowth: Should We Bother?  PMID: 26902227
  • Predicting a Response to Antibiotics in Patients with the Irritable Bowel Syndrome.  PMID: 26362282
  • How to Test and Treat Small Intestinal Bacterial Overgrowth: an Evidence-Based Approach.  PMID: 26780631
  • [Hydrogen Breath Tests]. German.  PMID: 26886040
  • Clinical value of radionuclide small intestine transit time measurement combined with lactulose hydrogen breath test for the diagnosis of bacterial overgrowth in irritable bowel syndrome.  PMID: 27331205
  • Hydrogen Breath Testing With Measurement of Orocecal Transit for Diagnosis of Small Bowel Bacterial Overgrowth.  PMID: 27094580
  • Hydrogen sulphide in exhaled breath: a potential biomarker for small intestinal bacterial overgrowth in IBS.  PMID: 27163246
  • Does Carbohydrate Challenge Testing Predict Clinical Response in Small Intestinal Bacterial Overgrowth?  PMID: 27135726
  • Refining small intestinal bacterial overgrowth diagnosis by means of carbohydrate specificity: a proof-of-concept study.  PMID: 27134657
  • Clinical experience with the use of anti-CdtB and anti-vinculin antibodies in patients with diarrhea in Mexico. PMID: 27681080
  • Hydrogen Breath Testing With Measurement of Orocecal Transit for Diagnosis of Small Bowel Bacterial Overgrowth. PMID: 27094580
  • Association between small intestinal bacterial overgrowth and deep vein thrombosis in patients with spinal cord injuries. PMID: 27930853
  • Letter to the Editor: Small intestinal bowel gas and breath hydrogen after ingestion of lactulose.


Methane
  • Irritable Bowel Syndrome, Particularly the Constipation-Predominant Form, Involves an Increase in Methanobrevibacter smithii, Which Is Associated with Higher Methane Production.  PMID: 27458176

Treatment
  • How to Test and Treat Small Intestinal Bacterial Overgrowth: an Evidence-Based Approach.  PMID: 26780631
  • Diagnosis and treatment of small intestinal bacterial overgrowth.  PMID: 26636484
  • Lubiprostone Accelerates Intestinal Transit and Alleviates Small Intestinal Bacterial Overgrowth in Patients With Chronic Constipation.  PMID: 27650225

Treatment: Methane
  • Review article: inhibition of methanogenic archaea by statins as a targeted management strategy for constipation and related disorders.  PMID: 26559904
  • Metabolic effects of eradicating breath methane using antibiotics in prediabetic subjects with obesity.  PMID: 26833719
  • Response of irritable bowel syndrome with constipation patients administered a combined quebracho/conker tree/M. balsamea Willd extract (Atrantil).  PMID: 27602249

Treatment: Herbal Antibiotics
  • Response of irritable bowel syndrome with constipation patients administered a combined quebracho/conker tree/M. balsamea Willd extract (Atrantil).  PMID: 27602249

Treatment: Antibiotics
  • Predicting a Response to Antibiotics in Patients with the Irritable Bowel Syndrome.  PMID: 26362282
  • A proof-of-concept study showing antibiotics to be more effective in irritable bowel syndrome with than without small-intestinal bacterial overgrowth: a randomized, double-blind, placebo-controlled trial.  PMID: 26731696

Treatment: Rifaximin
  • Review article: potential mechanisms of action of rifaximin in the management of irritable bowel syndrome with diarrhoea. PMID: 26618924
  • [Clinical features of irritable bowel syndrome with small intestinal bacterial overgrowth and a preliminary study of effectiveness of Rifaximin].  PMID: 27373356
  • Use of rifaximin in gastrointestinal and liver diseases. PMID: 27547007
  • Limited prolonged effects of rifaximin treatment on irritable bowel syndrome-related differences in the fecal microbiome and metabolome. PMID: 27662586
  • Rifaximin Exerts Beneficial Effects Independent of its Ability to Alter Microbiota Composition. PMID: 27560928
  • Repeat Treatment With Rifaximin is Safe and Effective in Patients With Diarrhea-predominant Irritable Bowel Syndrome. PMID: 27528177
  • Rifaximin, a non-absorbable antibiotic, inhibits the release of pro-angiogenic mediators in colon cancer cells through a pregnane X receptor-dependent pathway. PMID: 27279570
  • Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation. PMID: 27440420

Prokinetics
  • The motilin receptor agonist erythromycin stimulates hunger and food intake through a cholinergic pathway.  PMID: 26817505

Probiotics
  • Poor predictive value of breath hydrogen response for probiotic effects in IBS.  PMID: 26095068
  • Effect of probiotics on small intestinal bacterial overgrowth in patients with gastric and colorectal cancer.  PMID: 27210778

Low FODMAP Diet
  • Altered gastrointestinal microbiota in irritable bowel syndrome and its modification by diet: probiotics, prebiotics and the low FODMAP diet.  PMID: 26908093
  • Food: The Main Course to Wellness and Illness in Patients With Irritable Bowel Syndrome.  PMID: 26856749
  • Fermentable Carbohydrate Restriction (Low FODMAP Diet) in Clinical Practice Improves Functional Gastrointestinal Symptoms in Patients with Inflammatory Bowel Disease.  PMID: 26914438
  • Randomised clinical trial: low-FODMAP rye bread vs. regular rye bread to relieve the symptoms of irritable bowel syndrome.  PMID: 27417338
  • Challenges of Quantifying FODMAPs in Enteral Nutrition Formulas: Evaluation of Artifacts and Solutions.  PMID: 27406943
  • Efficacy of the low FODMAP diet for treating irritable bowel syndrome: the evidence to date.  PMID: 27382323
  • Case Study: Utilizing a Low FODMAP Diet to Combat Exercise-Induced Gastrointestinal Symptoms.  PMID: 27097380
  • Follow-up of patients with functional bowel symptoms treated with a low FODMAP diet.  PMID: 27099444
  • Consistent Prebiotic Effect on Gut Microbiota With Altered FODMAP Intake in Patients with Crohn's Disease: A Randomised, Controlled Cross-Over Trial of Well-Defined Diets.  PMID: 27077959
  • A low FODMAP diet in patients with Crohn's disease.  PMID:  26990906
  • Fermentable Carbohydrate Restriction (Low FODMAP Diet) in Clinical Practice Improves Functional Gastrointestinal Symptoms in Patients with Inflammatory Bowel Disease.  PMID: 26914438
  • Does a diet low in FODMAPs reduce symptoms associated with functional gastrointestinal disorders? A comprehensive systematic review and meta-analysis.  PMID: 25982757
  • Randomised clinical trial: the efficacy of gut-directed hypnotherapy is similar to that of the low FODMAP diet for the treatment of irritable bowel syndrome.  PMID: 27397586
  • Editorial: gut-directed hypnotherapy or low FODMAP diet for the treatment of irritable bowel syndrome? PMID: 27634230
  • Editorial: gut-directed hypnotherapy or low FODMAP diet for the treatment of irritable bowel syndrome? Authors' reply. PMID: 27634231
  • A Randomized Controlled Trial Comparing the Low FODMAP Diet vs. Modified NICE Guidelines in US Adults with IBS-D. PMID: 27725652
  • Restriction of FODMAP in the management of bloating in irritable bowel syndrome. PMID: 27664186
  • Low FODMAP diet efficacy in IBS patients-what is the evidence and what else do we need to know? PMID: 27657161
  • Managing irritable bowel syndrome: The low-FODMAP diet. PMID: 27618353
  • Fecal Fermentation in Irritable Bowel Syndrome: Influence of Dietary Restriction of Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols. PMID: 27487397
  • Effects of varying dietary content of fermentable short-chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome. PMID: 27747984
  • Logical hypothesis: Low FODMAP diet to prevent diverticulitis. PMID: 27867683
  • Case Study: Utilizing a Low FODMAP Diet to combat exercise-induced gastrointestinal symptoms. PMID: 27097380
  • The cornerstone of dietary management for fructose intolerance is the individual reduction of fructose intake and the FODMAP diet, led by a trained dietetician. PMID: 27774805
  • Effects of varying dietary content of fermentable short-chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome. PMID: 27747984
  • A randomized controlled trial comparing the Low FODMAP Diet vs. Modified NICE Guidelines in U.S. adults with IBS-D. PMID: 27725652


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