2021 Research Articles

  Overview     
Pathophysiology         Commentary: Hydrogen sulfide bacteria 
         Dr. Pimentel and team have linked hydrogen sulfide SIBO to fusobacterium varium bacteria, in this animal study. 
         On twitter, Dr. Pimentel commented: “Could this be the culprit in IBS contributing to diarrhea and a positive H2S on new 4 gas            breath test? Stay tuned.”

Causes/Risk Factors
Diseases PPI's/Hypochlorhydria Surgery/Injury 
Serum Gastrin Predicts Hydrogen-Producing Small Intestinal Bacterial Overgrowth in Patients With Abdominal Surgery: A Prospective Study.  DOI: 10.14309/ctg.0000000000000291 ​
​Associated Conditions
Children Chronic diarrhea Common Variable Immune Disease (CVID) NEW! Diabetes (Gestaional) NEW! Diverticula  Dyspepsia  Fructose Malabsorption  Functional Dyspepsia GERD  Heart Failure   IBS Intestinal Failure  Liver Disease  Lyme Disease and Tick Borne Illness  Pancreatic Disease  Parkinson’s disease  Rosacea   Short Bowel Syndrome Spinal Cord Injury NEW! Spondylarthropathy NEW! Systemic Sclerosis  Thyroid
 Testing
 Methane Hydrogen Sulfide          Commentary: Hydrogen sulfide bacteria
          Dr. Pimentel and team have linked hydrogen sulfide SIBO to fusobacterium varium bacteria, in this animal study. 
          On twitter, Dr. Pimentel commented: “Could this be the culprit in IBS contributing to diarrhea and a positive H2S on new 4                  gas breath test? Stay tuned.”
Treatment
  • Effects of Bovine Colostrum with or without Egg on In Vitro Bacterial-Induced Intestinal Damage with Relevance for SIBO and Infectious Diarrhea  PMID: 33809940
    Commentary: This study shows Colostrum, with its immunoglobulins, epithelial growth factors and more, helps protect against leaky gut and small intestine damage in SIBO.  
    “We conclude that BC [bovine colostrum] ± egg strengthens mucosal integrity against a battery of bacteria relevant for SIBO and for infectious diarrhea. Oral BC ± egg may have clinical value for these conditions, especially SIBO where eradication of precipitating organisms may be difficult to achieve.”
    Brands of Colostrum that I have used and like, include Symbiotics and NuMedica. Note that colostrum is a dairy product. Non-dairy immunoglobulins are available as serum bovine immunoglobulins: see my SIBO Symptomatic Relief Handout under Diarrhea, for products.
Antibiotics   Antibiotics: Rifaximin Elemental Diet  Herbal Antibiotics   FMT (Fecal Microbiota Transplantation)  Diet   Methane
  • Homemade Elemental Diet to Treat Intestinal Methanogen Overgrowth: A Case Report.(see "Research Updates" above this section)​

Diet: FODMAP          Commentary: Cool! Lupine milk is high protein and low fodmap. Now, where can we get it?