2021 - SIBO - Small Intestine Bacterial Overgrowth

2021 Research Articles

Related

Age and the aging process significantly alter the small bowel microbiome. PMID: 34592155

Overview

Other Diseases of the Small Intestine and Colon. DOI 10.1016/B978-0-323-67293-1.00049-9
Small Intestinal Bacterial Overgrowth PMID: 34024452
Small Intestinal Bacterial Overgrowth. PMID: 31536241

Pathophysiology

The role of intraepithelial lymphocytes in pathogenesis of small intestinal bacterial overgrowth syndrome]. PMID: 33713088
A LOWER RISK FOR VITAMIN B12 DEFICIENCY DISTINGUISHES SMALL INTESTINAL BACTERIAL OVERGROWTH (SIBO) CAUSED BY METHANE-PRODUCING ARCHAEA FROM SIBO CAUSED BY HYDROGEN-PRODUCING BACTERIA doi: 10.1016/S0016-5085(21)01603-6
Serotonin Pathway of Tryptophan Metabolism in Small Intestinal Bacterial Overgrowth-A Pilot Study with Patients Diagnosed with Lactulose Hydrogen Breath Test and Treated with Rifaximin PMID: 34065903
THE FIRST SYSTEMS BIOLOGY APPROACH TO THE MICROBIOME OF SIBO BY HIGH-LEVEL CO-OCCURRENCE COMMUNITY NETWORK ANALYSES IDENTIFIES TWO DISTINCT PROTEOBACTERIA-RELATED CLUSTERS DOI:10.1016/S0016-5085(21)01386-X
TRANSPLANTATION OF FUSOBACTERIUM VARIUM IN VIVO RESULTS IN AN INCREASE OF PRO-INFLAMMATORY CYTOKINES AND STOOL WET WEIGHT DOI:10.1016/S0016-5085(21)02071-0 Commentary: Hydrogen sulfide bacteria fusobacterium varium: On twitter, Dr. Pimentel commented: “Could this be the culprit in IBS contributing to diarrhea and a positive H2S on new 4 gas breath test? Stay tuned.”

Mucosa-Associated Microbial Profile Is Altered in Small Intestinal Bacterial Overgrowth PMID: 34421869
Quantitative sequencing clarifies the role of disruptor taxa, oral microbiota, and strict anaerobes in the human small-intestine microbiome PMID: 34724979 “Our findings support a strong relationship between overgrowth of specific disruptor taxa and GI symptoms in subjects with SIBO. High total microbial load alone in the small intestine, was not associated with GI symptoms usually observed in subjects with SIBO and other GI conditions and diseases.”

Causes/Risk Factors
Diseases

[Diverticula in the gastrointestinal tract]. PMID: 33560449
Association of Presenting Symptoms With Abnormal Laboratory Values for Vector-Borne Illness - Experience in an Urban Gastroenterology Practice. PMID: 33511252
Effects of Proton Pump Inhibitors on the Small Bowel and Stool Microbiomes. PMID: 33534012
Percutaneous endoscopic gastrojejunostomy in pediatric intestinal pseudo-obstruction PMID: 33601120

PPI's/Hypochlorhydria

PREVALENCE AND ASSOCIATION OF VITAMIN B12 DEFICIENCY AND SMALL INTESTINAL BACTERIAL OVERGROWTH IN PATIENTS TAKING PROTON PUMP INHIBITORS doi.org/10.1016/S0016-5085(21)02073-4

Short Bowel Syndrome

Small Intestine Obstruction

Surgery: Gastrectomy and Roux-en-Y

Gastrectomy impact on the gut microbiome in patients with gastric cancer: A comprehensive review. PMID: 34354801
Proximal Gastrectomy Is a Viable Alternative to Total Gastrectomy in Early Stage Proximal Gastric Cancer. PMID: 34483639
The Impact of Bariatric Surgery on the Development of Small Intestinal Bacterial Overgrowth (SIBO). doi:10.1016/j.jamcollsurg.2021.08.028
Assessment of the Burden of Small Intestinal Bacterial Overgrowth (SIBO) in Patients After Oesophagogastric (OG) Cancer Resection PMID: 34671913

Surgery/Injury 

Serum Gastrin Predicts Hydrogen-Producing Small Intestinal Bacterial Overgrowth in Patients With Abdominal Surgery: A Prospective Study. DOI: 10.14309/ctg.0000000000000291
Small intestinal bacterial overgrowth in spinal cord injury patients. PMID: 33640466

Associated Conditions
Alzheimer's disease NEW

Small intestinal bacterial overgrowth in Alzheimer's disease PMID: 34797427

Cancer

Assessment of the Burden of Small Intestinal Bacterial Overgrowth (SIBO) in Patients After Oesophagogastric (OG) Cancer Resection PMID: 34671913

Children

Chronic diarrhea

Common Variable Immune Disease (CVID) NEW

Can concurrent lower gastrointestinal manifestations help the timely diagnosis of small intestinal bacterial overgrowth in CVID patients? PMID: 32186350

Diabetes (Gestaional) NEW

Application of methane and hydrogen-based breath test in the study of gestational diabetes mellitus and intestinal microbes PMID: 33932493

Diverticula

[Diverticula in the gastrointestinal tract]. PMID: 33560449

Dyspepsia

Small Intestinal Bacterial Overgrowth in Functional Dyspepsia: A Systematic Review and Meta-Analysis. PMID: 33734110

Fructose Malabsorption

Fructose malabsorption: Causes, diagnosis and treatment PMID: 33818329

Functional Dyspepsia

GERD

The prevalence of intestinal dysbiosis in patients referred for antireflux surgery. PMID: 33475845
PREVALENCE AND ASSOCIATION OF VITAMIN B12 DEFICIENCY AND SMALL INTESTINAL BACTERIAL OVERGROWTH IN PATIENTS TAKING PROTON PUMP INHIBITORS doi.org/10.1016/S0016-5085(21)02073-4

Heart Failure

Hypothyroid

Levothyroxine Sodium Oral Solution Normalizes Thyroid Function in a Patient with Hashimoto's Disease, Gastritis, Diabetic Gastroparesis, and Small Intestinal Bacterial Overgrowth (SIBO). PMID: 34557042

IBS

Correlation between small intestinal bacterial overgrowth and irritable bowel syndrome and the prognosis of treatment PMID: 33849121
RIFAXIMIN IMPROVES BOTH ABDOMINAL PAIN AND BLOATING IN PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH DIARRHEA: A COMPOSITE ENDPOINT ANALYSIS OF TWO PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED TRIALS doi.org/10.1016/S0016-5085(21)01398-6
RIFAXIMIN SIGNIFICANTLY IMPROVES BOWEL MOVEMENT URGENCY IN PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH DIARRHEA: A POOLED ANALYSIS OF THREE PHASE 3 TRIALS doi.org/10.1016/S0016-5085(21)01399-8
Emerging Role of the Gut Microbiome in Irritable Bowel Syndrome PMID: 34304786
Uncovering the pathophysiology of irritable bowel syndrome by exploring the gut-brain axis: a narrative review PMID: 34430628
A Comprehensive Review of Transaminitis and Irritable Bowel Syndrome PMID: 34322359
Small Intestinal Bacterial Overgrowth In Various Functional Gastrointestinal Disorders: A Case-Control Study PMID: 34417923

Inflammatory Bowel Disease

Small intestinal bacterial overgrowth and evaluation of intestinal barrier function in patients with ulcerative colitis PMID: 34306403

Small intestinal bacterial overgrowth in patients with inflammatory bowel disease: A case-control study PMID: 34390471

Intestinal Failure

[Mechanism of gut-microbiota-liver axis in the pathogenesis of intestinal failure-associated liver disease]. PMID: 33461259
[Chronic intestinal failure] PMID: 34264370

Liver Disease

Lyme Disease and Tick Borne Illness

Association of Presenting Symptoms With Abnormal Laboratory Values for Vector-Borne Illness - Experience in an Urban Gastroenterology Practice. PMID: 33511252

Pancreatic Disease

Parkinson’s disease

Rosacea

Short Bowel Syndrome

Fecal microbiome alterations in pediatric patients with short bowel syndrome receiving a rotating cycle of gastrointestinal prophylactic antibiotics. PMID: 34156541

Spinal Cord Injury

Small intestinal bacterial overgrowth in spinal cord injury patients. PMID: 33640466
Small intestinal bacterial overgrowth in spinal cord injury patients DOI: 10.1016/j.gastre.2021.09.005

Spondylarthropathy NEW

High prevalence of small intestinal bacterial overgrowth (SIBO) in spondylarthropathy. PMID: 33427609

Systemic Sclerosis

Prevalence and predictors of small intestinal bacterial overgrowth in systemic sclerosis: a systematic review and meta-analysis. PMID: 33426631

Thyroid

Small Intestinal Bacterial Overgrowth in Subclinical Hypothyroidism of Pregnant Women. PMID: 34108932

Testing

Methane

Methane and fatty acid metabolism pathways are predictive of Low-FODMAP diet efficacy for patients with irritable bowel syndrome. PMID: 33504454
AN ELEVATION IN METHANE IS ASSOCIATED WITH AN ANTI-INFLAMMATORY CYTOKINE PROFILE SIMILAR TO GLUCOCORTICOIDS DOI:10.1016/S0016-5085(21)02322-2
Pattern of methane levels with lactulose breath testing; can we shorten the test duration? PMID: 34263076
Distinctive Clinical Correlates of Small Intestinal Bacterial Overgrowth with Methanogens doi:10.1016/j.cgh.2021.09.035
Meconial Methanobrevibacter smithii suggests intrauterine methanogen colonization in preterm neonates. PMID: 34841325
Exhaled Methane is Associated with a Lower Heart Rate. PMID: 34915468

Hydrogen Sulfide

TRANSPLANTATION OF FUSOBACTERIUM VARIUM IN VIVO RESULTS IN AN INCREASE OF PRO-INFLAMMATORY CYTOKINES AND STOOL WET WEIGHT DOI:10.1016/S0016-5085(21)02071-0

Commentary: Hydrogen sulfide bacteria fusobacterium varium: On twitter, Dr. Pimentel commented: “Could this
be the culprit in IBS contributing to diarrhea and a positive H2S on new 4 gas breath test? Stay tuned.”

EXHALED HYDROGEN SULFIDE IS INCREASED IN PATIENTS WITH DIARRHEA- RESULTS OF A NOVEL COLLECTION AND BREATH TESTING DEVICE DOI:10.1016/S0016-5085(21)01391-3
[The diagnostic value of hydrogen sulfide breath test for small intestinal bacterial overgrowth] PMID: 33765706

Treatment

Effects of Bovine Colostrum with or without Egg on In Vitro Bacterial-Induced Intestinal Damage with Relevance for SIBO and Infectious Diarrhea PMID: 33809940 Commentary: This study shows Colostrum, with its immunoglobulins, epithelial growth factors and more, helps protect against leaky gut and small intestine damage in SIBO. For brands of Colostrum that I have used and like, including non-dairy options: see my SIBO Symptomatic Relief Handout under Diarrhea.
Management of small intestinal bacterial overgrowth by pediatric gastroenterologists in Spain PMID: 33371710
Management of small intestinal bacterial overgrowth by pediatric gastroenterologists in Spain PMID: 33371710

Antibiotics

Antibiotics: Rifaximin

Elemental Diet

Homemade Elemental Diet to Treat Intestinal Methanogen Overgrowth: A Case Report.(see "Research Updates" above this section)

Herbal Antibiotics

NEW Chinese herbal medicine for the treatment of small intestinal bacterial overgrowth (SIBO ): A protocol for systematic review and meta-analysis. PMID: 33371127

FMT (Fecal Microbiota Transplantation)

Clinical efficacy of fecal microbiota transplantation for patients with small intestinal bacterial overgrowth: a randomized, placebo-controlled clinic study. PMID: 33549047

Diet

Impact of Diet on Symptoms of the Irritable Bowel Syndrome. PMID: 33572262
Homemade Elemental Diet to Treat Intestinal Methanogen Overgrowth: A Case Report.

Prokinetics

Deja-vu? Neural and behavioural effects of the 5-HT(4) receptor agonist, prucalopride, in a hippocampal-dependent memory task. PMID: 34602607 ..."these findings demonstrate the potential of 5-HT4-receptor activation [prucalopride] for cognitive enhancement in humans.”

Diet: FODMAP

Treatment efficacy of a low FODMAP diet compared to a low lactose diet in IBS patients: A randomized, cross-over designed study. PMID: 33183577
Low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol diet in patients with diarrhea-predominant irritable bowel syndrome: A prospective, randomized trial. PMID: 33464683
Methane and fatty acid metabolism pathways are predictive of Low-FODMAP diet efficacy for patients with irritable bowel syndrome. PMID: 33504454
Habitual FODMAP Intake in Relation to Symptom Severity and Pattern in Patients with Irritable Bowel Syndrome. PMID: 33374779
Irritable Bowel Syndrome: Food as a Friend or Foe? PMID: 33518164
Fundamental study on changes in the FODMAP profile of cereals, pseudo-cereals, and pulses during the malting process. DOI 10.1016/j.foodchem.2020.128549
What is the optimal FODMAP threshold in IBS? PMID: 33624857
Dietary interventions and irritable bowel syndrome - what really works? PMID: 33332914
Editorial: defining a microbial signature to predict non-response to a FODMAP diet-a step closer or is it? PMID: 33566410
Editorial: defining a microbial signature to predict non-response to a low FODMAP diet-a step closer or is it? Authors' reply. PMID: 33566399
Efficacy of a low-FODMAP diet in adult irritable bowel syndrome: a systematic review and meta-analysis. PMID: 33585949
The role of diet in the pathophysiology and management of irritable bowel syndrome. PMID: 33666892
Long-term symptom severity in people with irritable bowel syndrome following dietetic treatment in primary care: A service evaluation. PMID: 33761153
Reducing FODMAPs and improving bread quality using type II sourdough with selected starter cultures. PMID: 33653200
Low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols diet compared with traditional dietary advice for diarrhea-predominant irritable bowel syndrome: a parallel-group, randomized controlled trial with analysis of clinical and microbiological factors associated with patient outcomes. PMID: 33740048
FODMAP Fingerprinting of Bakery Products and Sourdoughs: Quantitative Assessment and Content Reduction through Fermentation PMID: 33921672
The low FODMAP diet for IBS; A multicentre UK study assessing long term follow up PMID: 34083153
Low FODMAP (fermentable oligo-, di-, monosaccharides, and polyol) diet goes global PMID: 33851195
Diarrhea Predominant-Irritable Bowel Syndrome (IBS-D): Effects of Different Nutritional Patterns on Intestinal Dysbiosis and Symptoms PMID: 33946961
Low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet is associated with increased risk of uninvestigated chronic dyspepsia and its symptoms in adults PMID: 33971708
The Relationship between Low Serum Vitamin D Levels and Altered Intestinal Barrier Function in Patients with IBS Diarrhoea Undergoing a Long-Term Low-FODMAP Diet: Novel Observations from a Clinical Trial PMID: 33801020
Gluten and FODMAPs Relationship with Mental Disorders: Systematic Review PMID: 34072914
Intestinal microbiota fingerprint in subjects with irritable bowel syndrome responders to a low FODMAP diet PMID: 33877245
Better response to low FODMAP diet in DGBI patients with pronounced hydrogen response to a nutrient challenge test PMID: 34107550
Epigastric symptom response to low FODMAP dietary advice compared with standard dietetic advice in individuals with functional dyspepsia PMID: 33844408
High-Fat Foods and FODMAPs Containing Gluten Foods Primarily Contribute to Symptoms of Irritable Bowel Syndrome in Korean Adults PMID: 33920966
Physicochemical and nutritional properties of high protein emulsion-type lupin-based model milk alternatives: effect of protein source and homogenization pressure PMID: 33792053 Commentary: Lupine milk is high protein and low fodmap.
Characteristics and properties of fibres suitable for a low FODMAP diet- an overview doi.org/10.1016/j.tifs.2021.04.023
Low Fodmap Diet & Prebiotic β-Galactooligosaccharides Improve Irritable Bowel Syndrome with no Impact on α-Diversity and Response to Low Fodmap Diet is Predicted by Urine and Fecal Metabolites: A Randomised Controlled Trial doi.org/10.1016/S0016-5085(18)32410-7
LOW FODMAP DIET ADHERENCE IS HIGH AND POSITIVELY IMPACTS NUTRITIONAL INTAKE AND DIET QUALITY IN CHILDREN WITH IRRITABLE BOWEL SYNDROME (IBS) doi.org/10.1016/S0016-5085(21)02515-4
β-fructosidase FosE activity in Lactobacillus paracasei regulates fructan degradation during sourdough fermentation and total FODMAP levels in steamed bread doi.org/10.1016/j.lwt.2021.111294
THE ROLE OF ILLNESS PERCEPTIONS IN TREATMENT RESPONSE OF ADULTS WITH IBS UNDERGOING LOW FODMAP DIET INTERVENTION: A PROSPECTIVE STUDY. doi.org/10.1016/S0016-5085(21)02334-9
MAST-CELL ACTIVATION LEADING TO COLONIC BARRIER DYSFUNCTION FOLLOWING HIGH-FODMAP DIET IS MEDIATED VIA LIPOPOLYSACCHARIDE doi.org/10.1016/S0016-5085(21)00924-0
EVALUATING THE FACTUAL ACCURACY OF LOW FODMAP DIETARY CONTENT ON INSTAGRAM: A BLINDED, DIETITIAN-RATED ANALYSIS doi.org/10.1016/S0016-5085(21)02490-2
FODMAPS, BUT NOT GLUTEN, ELICIT MODEST SYMPTOMS OF IRRITABLE BOWEL SYNDROME: DOUBLE-BLIND, PLACEBO-CONTROLLED RANDOMISED THREE-WAY CROSSOVER TRIAL doi.org/10.1016/S0016-5085(21)00927-6
ARE ALL FODMAPS CREATED EQUAL? A BLINDED, RANDOMIZED REINTRODUCTION TRIAL TO DETERMINE WHICH FODMAPS DRIVE CLINICAL RESPONSE IN IBS PATIENTS doi.org/10.1016/S0016-5085(21)02493-8
FODMAP Consumption by Adults from the French Population-Based NutriNet-Santé Cohort PMID: 34224572
Efficacy of a low FODMAP diet in irritable bowel syndrome: systematic review and network meta-analysis PMID: 34376515
Long-term personalized low FODMAP diet improves symptoms and maintains luminal Bifidobacteria abundance in irritable bowel syndrome PMID: 34431172
Better response to low FODMAP diet in disorders of gut-brain interaction patients with pronounced hydrogen response to a nutrient challenge test PMID: 34107550
Psychological and Gastrointestinal Symptoms of Patients with Irritable Bowel Syndrome Undergoing a Low-FODMAP Diet: The Role of the Intestinal Barrier PMID: 34371976
Influence of low FODMAP-gluten free diet on gut microbiota alterations and symptom severity in Iranian patients with irritable bowel syndrome PMID: 34261437
A Low-FODMAP Diet Improves the Global Symptoms and Bowel Habits of Adult IBS Patients: A Systematic Review and Meta-Analysis PMID: 34490319
Effect of Low FODMAPs Diet on Irritable Bowel Syndromes: A Systematic Review and Meta-Analysis of Clinical Trials PMID: 34371973
Correction to: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome: a systematic review and meta-analysis PMID: 34181070
Diet Interventions for Irritable Bowel Syndrome: Separating the Wheat from the Chafe PMID: 34304788
Designing New Foods or Food Ingredients Targeting the Gut Microbiota to Reduce FODMAP-Induced Irritable Bowel Syndrome (IBS) DOI:10.1016/B978-0-12-819265-8.00093-0
The FODMAP diet: more than just a symptomatic therapy? PMID: 34810233
High FODMAP diet causes barrier loss via lipopolysaccharide-mediated mast cell activation PMID: 34618688 "Our findings indicate that a HFM diet causes mast cell activation via LPS, which in turn leads to colonic barrier loss, and a LFM diet reverses these pathophysiologic mucosal changes."
Group education on the low FODMAP diet improves gastrointestinal symptoms but neither anxiety or depression in irritable bowel syndrome PMID: 34705305
Effects of a low-FODMAP enteral formula on diarrhea on patients in the intensive care unit PMID: 34858549
Two microbiota subtypes identified in irritable bowel syndrome with distinct responses to the low FODMAP diet PMID: 34810234 "50% of IBS cases manifested a 'pathogenic' gut microbial signature. This shifted towards the healthy profile on the low FODMAP diet... with an increase in Bacteroidetes, a decrease in Frimicutes species and normalisation of primary metabolic genes."
Adult celiac disease with persistent IBS-type symptoms: a pilot study of an adjuvant FODMAP diet PMID: 34659657
Lachancea fermentati FST 5.1: an alternative to baker's yeast to produce low FODMAP whole wheat bread PMID: 34710210
Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols (FODMAPs) and cancer risk in the prospective NutriNet-Santé cohort PMID: 34718693
FODMAPs, but not gluten, elicit modest symptoms of irritable bowel syndrome: a double-blind, placebo-controlled, randomized three-way crossover trial PMID: 34617561
Supplementing dietary fibres with a low FODMAP diet in irritable bowel syndrome: a randomized controlled crossover trial doi:10.1016/j.cgh.2021.12.016
Non-pharmacologic strategies for the management of intestinal inflammation PMID: 34808552