2019 - SIBO- Small Intestine Bacterial Overgrowth

2019 Research Articles

Overview

The Spectrum of Small Intestinal Bacterial Overgrowth (SIBO). PMID: 30645678
Small Intestinal Bacterial Overgrowth: Clinical Features and Therapeutic Management. PMID: 31584459
Small Intestinal Bacterial Overgrowth in Children: A State-Of-The-Art Review. PMID: 31552207
Small Intestinal Bacterial Overgrowth. PMID: 31536241
Is A Real Condition? PMID: 31550680

Pathophysiology

Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production. PMID: 31138751
Mo1615 – Fat-Soluble Vitamins, B12, and Iron Deficiency in Patients with Coliform Small Intestinal Bacterial Overgrowth. DOI: 10.1016/S0016-5085(19)38959-0
4 – First Large Scale Study Defining the Characteristic Microbiome Signatures of Small Intestinal Bacterial Overgrowth (SIBO): Detailed Analysis from the Reimagine Study. DOI: 10.1016/S0016-5085(19)36776-9
Sa1755 – Presenting Symptom Severity and Health-Related Quality of Life Do Not Predict Lactulose Breath Test Outcomes in Patients with Suspected Small Intestinal Bacterial Overgrowth. DOI: 10.1016/S0016-5085(19)37822-9
Sa1911 – Analysis of the Small Intestinal Microbiome Reveals Marked Differences from Stool Microbiome in a Large Scale Human Cohort: Redefining the “Gut Microbiome”. DOI: 10.1016/S0016-5085(19)37977-6

Causes/ Risk Factors

Appendicitis NEW

1149 – Microbial Sequencing of the Appendiceal Microbiome Reveals Elevated Levels of C. Jejuni in Acute Appendicitis doi: 10.1016/S0016-5085(19)37416-5

Biofilm

443 – Intestinal Biofilms are an Endoscopic Feature of Irritable Bowel Syndrome. DOI: 10.1016/S0016-5085(19)37016-7

Food Poisoning

Sa1954 – Post Infection IBS (PI-IBS) is Very Infrequent in Mexico and Patients Have Similar Characteristics Than Those with Non Pi-Ibs Ones. DOI: 10.1016/S0016-5085(19)38020

PPI's/Hypochlorhydria

Bowel symptoms in patients that receive proton pump inhibitors. Results of a multicenter survey in Mexico. PMID: 29678362
979 – A Large Scale Evaluation of the Small Intestinal Microbiome in Subjects on Proton Pump Inhibitors. DOI: 10.1016/S0016-5085(19)37311-1

Surgery

Lactulose Breath Testing Can Be a Positive Predictor Before Weight Gain in Participants with Obesity Submitted to Roux-en-Y Gastric Bypass. PMID: 31187458
Small intestinal bacterial overgrowth is common after gastrectomy but with little impact on nutritional status. DOI: 10.1016/j.gastre.2019.01.007

Associated Conditions

Anorexia Nervosa NEW

Microbiota, Microbial Metabolites, and Barrier Function in A Patient with Anorexia Nervosa after Fecal Microbiota Transplantation. PMID: 31510101

Anxiety/Depression

858 – Therapeutic Response to Small Intestinal Bacterial Overgrowth (SIBO) in Irritable Bowel Syndrome (IBS). is It Useful to Test For?. DOI: 10.1016/S0016-5085(19)37267-1

Brain Fog

Mo1610 – Characterizing Symptoms of Brain Fogginess and Its Association with D-Lactic Acidosis and Sibo. DOI: 10.1016/S0016-5085(19)38954-1

Cancer NEW

Celiac Disease

METABOLIC ALTERATIONS IN CELIAC DISEASE OCCURRING AFTER FOLLOWING A GLUTEN-FREE DIET. DOI: 10.1159/000495749

Children (Pediatrics)

Cystic Fibrosis

Gut reaction: impact of systemic diseases on gastrointestinal physiology and drug absorption. DOI: 10.1016/j.drudis.2018.11.009

Diabetes

Diabetes and the gastrointestinal tract. DOI: 10.1016/j.mpmed.2019.04.011

Diverticular Disease

Environmental Enteric Dysfunction

Environmental enteric dysfunction and growth. PMID: 30629923

Gallbladder Disease

High occurrence of small intestinal bacterial overgrowth in primary biliary cholangitis. PMID: 31373141

GERD

Beneficial effect of probiotics supplements in reflux esophagitis treated with esomeprazole: A randomized controlled trial. PMID31114137

Heart Failure

Hydrogen- and Methane-Based Breath Testing and Outcomes in Patients With Heart Failure. DOI: 10.1016/j.cardfail.2018.10.004

Inflammatory Bowel Disease

Gastrointestinal motility and absorptive disorders in patients with inflammatory bowel diseases: Prevalence, diagnosis and treatment. PMID: 31496621

Systematic review with meta-analysis: the prevalence of small intestinal bacterial overgrowth in inflammatory bowel disease. PMID: 30735254

Intestinal Failure: Pediatric

Serum Unconjugated Bile Acids and Small Bowel Bacterial Overgrowth in Pediatric Intestinal Failure: A Pilot Study. PMID: 30035316

Liver Disease

Small intestinal bacterial overgrowth and nonalcoholic fatty liver disease. PMID:30915401
An assessment of bacterial overgrowth and translocation in the non-alcoholic fatty liver of patients with morbid obesity. PMID: 30896956
The role of Small Intestinal Bacterial Overgrowth (SIBO) in Non-alcoholic Fatty Liver Disease (NAFLD) patients evaluated using Controlled Attenuation Parameter (CAP) Transient Elastography (TE): a tertiary referral center experience. PMID: 30894137
Alcoholic liver disease and mast cells: What's your gut got to do with it? https://doi.org/10.1016/j.livres.2019.02.002
Role of the intestinal microbiome in liver fibrosis development and new treatment strategies. DOI: 10.1016/j.trsl.2019.02.005
Gut microbial dysbiosis associates hepatocellular carcinoma via the gut-liver axis. DOI:10.1016/j.hbpd.2018.11.002
An assessment of bacterial overgrowth and translocation in the non-alcoholic fatty liver of patients with morbid obesity. PMID: 30896956
Su1083 – Small Intestinal Bacterial Overgrowth and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. DOI: 10.1016/S0016-5085(19)40180-7
Mo2015 – The Role of Small Intestinal Bacteria Overgrowth in Nonalcoholic Fatty Liver Disease. DOI: 10.1016/S0016-5085(19)39278-9

Metabolic Syndrome

The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome. DOI: 10.1016/j.redox.2018.101091

Obesity (morbid)

An assessment of bacterial overgrowth and translocation in the non-alcoholic fatty liver of patients with morbid obesity. PMID: 30896956
Mo2023 – Association Between Obesity and Risk of Small Intestine Bacterial Overgrowth: A Systematic Review and Metaanalysis. DOI: 10.1016/S0016-5085(19)39287-X

Pancreatic Disease

Parkinson’s Disease

Gut reaction: impact of systemic diseases on gastrointestinal physiology and drug absorption. DOI: 10.1016/j.drudis.2018.11.009
Triggers, Facilitators, and Aggravators: Redefining Parkinson’s Disease Pathogenesis. DOI:10.1016/j.tins.2018.09.007

Polyderma faciale NEW

Pyoderma faciale in a patient with small intestinal bacterial overgrowth. PMID: 30968945

Restless Legs Syndrome

Restless Leg Syndrome: Does It Start With A Gut Feeling? https://doi.org/10.1093/sleep/zsz067.008

Sexual Dysfunction NEW

Could problems in the bedroom come from our intestines? A preliminary study of IBS and its impact on female sexuality. PMID: 31488791

Short Bowel Syndrome

Surgery: Gastric By-pass/Bariatric

Systemic Sclerosis

Testing

Impact of Oral-Cecal Transit Time on the Interpretation of Lactulose Breath Tests After RYGB: a Personalized Approach to the Diagnosis of SIBO. PMID: 30627990
Serum Unconjugated Bile Acids and Small Bowel Bacterial Overgrowth in Pediatric Intestinal Failure: A Pilot Study. PMID: 30035316
Noninvasive Magnetogastrography Detects Erythromycin-Induced Effects on the Gastric Slow Wave. PMID: 29993499 (MMC testing)
BREATH TESTS FOR SMALL INTESTINAL BACTERIAL OVERGROWTH DIAGNOSIS: A SYSTEMATIC REVIEW WITH META-ANALYSIS. https://doi.org/10.1016/S1590-8658(19)30442-6
Second-Generation Biomarker Testing for Irritable Bowel Syndrome Using Plasma Anti-CdtB and Anti-Vinculin Levels. PMID: 31152332
Gastric, small bowel and colonic motility and breath-testing. DOI: 10.1016/j.mpmed.2019.03.006
First Large Scale Study Defining the Characteristic Microbiome Signatures of Small Intestinal Bacterial Overgrowth (SIBO): Detailed Analysis from the Reimagine Study. DOI: 10.1016/S0016-5085(19)36776
Su1949 – Small Intestinal Aspirates Require Specific Treatment to Optimize Microbial Analysis: Validation of a Novel Technique from the Reimagine Study DOI: https://doi.org/10.1016/S0016-5085(19)38583-X
Sa1912 – Revealing the Entire Intestinal Microbiota and Its Associations to the Genetic, Immunologic, and Neuroendocrine Ecosystems: Methodology for the Reimagine Study. DOI: https://doi.org/10.1016/S0016-5085(19)37978-8
P.06.12 BREATH TESTS FOR SMALL INTESTINAL BACTERIAL OVERGROWTH DIAGNOSIS: A SYSTEMATIC REVIEW WITH META-ANALYSIS. DOI: 10.1016/S1590-8658(19)30442-6
Tu1873 – Bowel Cleansing May Affect Diagnostic Yield of Small Bowel Aspirates for Diagnosis of Sibo in Patients with Diarrhea. DOI: 10.1016/S0016-5085(19)39856-7
Tu1600 – Air Or Carbon Dioxide Insufflation in Upper Endoscopies and the Yield of Quantitative Small Bowel Aspirate Cultures. DOI: 10.1016/S0016-5085(19)39605-2
Sa1953 – Pictograms are Highly Effective for Diagnosing Abdominal Bloating and Distension in Patients with Irritable Bowel Syndrome (IBS). DOI: 10.1016/S0016-5085(19)38019-9
Su1949 – Small Intestinal Aspirates Require Specific Treatment to Optimize Microbial Analysis: Validation of a Novel Technique from the Reimagine Study. DOI: 10.1016/S0016-5085(19)38583-X
Changes in Fecal Calprotectin After Rifaximin Treatment in Patients With Nonconstipated Irritable Bowel Syndrome. DOI: 10.1016/j.amjms.2018.11.004.
Reaction of antibodies to Campylobacter jejuni and cytolethal distending toxin B with tissues and food antigens. PMID: 30862994
Zonulin in serum as a biomarker fails to identify the IBS, functional dyspepsia and non-coeliac wheat sensitivity. PMID: 31563879
Characterization of Proximal Small Intestinal Microbiota in Patients With Suspected Small Intestinal Bacterial Overgrowth: A Cross-Sectional Study. PMID: 3146469

Methane

Tu1887 – Patients with Appendectomy Have Significantly Less Methane in Their Exhaled Breath: is the Appendix a Vestigial Organ Or an Important Reservoir for Methanogens? doi: 10.1016/S0016-5085(19)39870-1
Tu1897 – Enteric Methane Or Hydrogen Production in Patients with Unexplained Gastrointestinal Symptoms: Associations with Age, Symptoms and Proton Pump Inhibitors doi: 10.1016/S0016-5085(19)39880-4
Su1635 – Oral Iron Supplementation, Microbiome Related Methanogenesis and Constipation - a Novel Model to Explain and Age Old Problem doi: 10.1016/S0016-5085(19)38374-X

Hydrogen Sulfide

SIBO AS AN ADAPTATION: A PROPOSED ROLE FOR HYDROGEN SULFIDE NDNR
Sa1918 – Jejunal But Not Colonic Hydrogen Sulfide Increased Portal Blood Flow But Not Portal Pressure. DOI: 10.1016/S0016-5085(19)37984-3

Treatment

Management of Small Intestinal Bacterial Overgrowth in Adult Patients. PMID: 31145251

Antibiotics

Effectiveness of Saccharomyces boulardii and Metronidazole for Small Intestinal Bacterial Overgrowth in Systemic Sclerosis. PMID: 31549334
Effect of Rifaximin Treatment on Endotoxemia and Insulin Sensitivity in Humans. PMID: 31428718
Changes in Fecal Calprotectin After Rifaximin Treatment in Patients With Nonconstipated Irritable Bowel Syndrome. DOI: 10.1016/j.amjms.2018.11.004.
Su1589 – Predictive Factors of Response to Rifaximin in Irritable Bowel Syndrome and Bacterial Overgrowth. DOI: 10.1016/S0016-5085(19)38328-3
444 – Rifaximin for Improving Abdominal Pain and Bloating Symptoms in Patients with Irritable Bowel Syndrome with Diarrhea (IBS-D) Using Modified Definitions of Pain Response. DOI: 10.1016/S0016-5085(19)37017-9
Mo1545 – Characterization of Abdominal Pain Response to Rifaximin in Patients with Irritable Bowel Syndrome with Diarrhea (IBSD), by Baseline Pain Severity

Prokinetics

Rikkunshito Depolarizes Pacemaker Potentials of Cultured Interstitial Cells of Cajal through Ghrelin Receptors in Murine Small Intestine. PMID: 30889598
Prucalopride for the treatment of constipation: a view from 2015 and beyond. PMID:30791758
Prucalopride, A Recently Approved Drug by the Food and Drug Administration for Chronic Idiopathic Constipation. PMID: 30820411
The effect of pyridostigmine on small intestinal bacterial overgrowth(SIBO) and plasma inflammatory biomarkers in HIV-associated autonomic neuropathies. PMID: 31098925
Mo1584 – Effectiveness of Lanreotide in the Treatment of Patients with Small Bowel Motility Disorder (SBMD). DOI: 10.1016/S0016-5085(19)38928-0
In brief: Tegaserod (Zelnorm) returns. PMID: 31169806
Prucalopride (Motegrity) for chronic idiopathic constipation. PMID: 31170120
Clinical Efficacy and Safety Profile of Prucalopride in Chronic Idiopathic Constipation. PMID: 31218146
Study Design and Cohort Comparability in a Study of Major Cardiovascular Events in New Users of Prucalopride Versus Polyethylene Glycol 3350. PMID: 31134513
Cardiovascular Safety of Prucalopride in Patients with Chronic Constipation: A Multinational Population-Based Cohort Study. PMID: 31134512
Use of prucalopride in adults with chronic idiopathic constipation. PMID: 31096799

Probiotics

Acupuncture

Acupuncture protects the interstitial cells of Cajal by regulating miR-222 in a rat model of post-operative ileus. PMID: 30852906

Ameliorating Effects of Electroacupuncture on Dysmotility, Inflammation and Pain Mediated via the Autonomic Mechanism in a Rat Model of Postoperative Ileus. PMID: 30827069

Fecal Microbiota Transplantation (FMT)

Microbiota, Microbial Metabolites, and Barrier Function in A Patient with Anorexia Nervosa after Fecal Microbiota Transplantation. PMID: 31510101
Tu1878 – Fecal Microbiota Transplantation (FMT) in Irritable Bowel Syndrome (IBS): A Systematic Review and Meta-Analysis. DOI: 10.1016/S0016-5085(19)39861-

Diet

FODMAP Diet