2019 - SIBO- Small Intestine Bacterial Overgrowth

2019 Research Articles

Overview

The Spectrum of Small Intestinal Bacterial Overgrowth (SIBO). PMID: 30645678
Small Intestinal Bacterial Overgrowth: Clinical Features and Therapeutic Management. PMID: 31584459
Small Intestinal Bacterial Overgrowth in Children: A State-Of-The-Art Review. PMID: 31552207
Small Intestinal Bacterial Overgrowth. PMID: 31536241
Is A Real Condition? PMID: 31550680

Pathophysiology

Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production. PMID: 31138751
Mo1615 – Fat-Soluble Vitamins, B12, and Iron Deficiency in Patients with Coliform Small Intestinal Bacterial Overgrowth. DOI: 10.1016/S0016-5085(19)38959-0
4 – First Large Scale Study Defining the Characteristic Microbiome Signatures of Small Intestinal Bacterial Overgrowth (SIBO): Detailed Analysis from the Reimagine Study. DOI: 10.1016/S0016-5085(19)36776-9
Sa1755 – Presenting Symptom Severity and Health-Related Quality of Life Do Not Predict Lactulose Breath Test Outcomes in Patients with Suspected Small Intestinal Bacterial Overgrowth. DOI: 10.1016/S0016-5085(19)37822-9
Sa1911 – Analysis of the Small Intestinal Microbiome Reveals Marked Differences from Stool Microbiome in a Large Scale Human Cohort: Redefining the “Gut Microbiome”. DOI: 10.1016/S0016-5085(19)37977-6
Carbohydrate Intolerance and Disaccharidase Measurement - a Mini-Review. PMID: 31857738

Causes/ Risk Factors

Appendicitis NEW

1149 – Microbial Sequencing of the Appendiceal Microbiome Reveals Elevated Levels of C. Jejuni in Acute Appendicitis doi: 10.1016/S0016-5085(19)37416-5

Biofilm

443 – Intestinal Biofilms are an Endoscopic Feature of Irritable Bowel Syndrome. DOI: 10.1016/S0016-5085(19)37016-7

Diseases

Increased fasting small-bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging. PMID: 31839961

Food Poisoning

Sa1954 – Post Infection IBS (PI-IBS) is Very Infrequent in Mexico and Patients Have Similar Characteristics Than Those with Non Pi-Ibs Ones. DOI: 10.1016/S0016-5085(19)38020

PPI's/Hypochlorhydria

Bowel symptoms in patients that receive proton pump inhibitors. Results of a multicenter survey in Mexico. PMID: 29678362
979 – A Large Scale Evaluation of the Small Intestinal Microbiome in Subjects on Proton Pump Inhibitors. DOI: 10.1016/S0016-5085(19)37311-1

Surgery

Lactulose Breath Testing Can Be a Positive Predictor Before Weight Gain in Participants with Obesity Submitted to Roux-en-Y Gastric Bypass. PMID: 31187458
Small intestinal bacterial overgrowth is common after gastrectomy but with little impact on nutritional status. DOI: 10.1016/j.gastre.2019.01.007
Bariatric Surgery and Its Complications in Inflammatory Bowel Disease Patients. PMID: 31626698
Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota. DOI: 10.1016/j.jpedsurg.2019.08.048

Weight

Associated Conditions

Anorexia Nervosa NEW

Microbiota, Microbial Metabolites, and Barrier Function in A Patient with Anorexia Nervosa after Fecal Microbiota Transplantation. PMID: 31510101

Anxiety/Depression

858 – Therapeutic Response to Small Intestinal Bacterial Overgrowth (SIBO) in Irritable Bowel Syndrome (IBS). is It Useful to Test For?. DOI: 10.1016/S0016-5085(19)37267-1

Brain Fog

Mo1610 – Characterizing Symptoms of Brain Fogginess and Its Association with D-Lactic Acidosis and Sibo. DOI: 10.1016/S0016-5085(19)38954-1

Cancer NEW

Celiac Disease

METABOLIC ALTERATIONS IN CELIAC DISEASE OCCURRING AFTER FOLLOWING A GLUTEN-FREE DIET. DOI: 10.1159/000495749

Children (Pediatrics)

Cholangitis NEW

A Mechanistic Insight Into the Role of Gut Microbiota in the Pathogenesis of Primary Sclerosing Cholangitis. DOI:10.1053/j.gastro.2019.10.012

Cystic Fibrosis

Gut reaction: impact of systemic diseases on gastrointestinal physiology and drug absorption. DOI: 10.1016/j.drudis.2018.11.009

Diabetes

Diabetes and the gastrointestinal tract. DOI: 10.1016/j.mpmed.2019.04.011

Diverticular Disease

Environmental Enteric Dysfunction

Environmental enteric dysfunction and growth. PMID: 30629923

Gallbladder Disease

High occurrence of small intestinal bacterial overgrowth in primary biliary cholangitis. PMID: 31373141

GERD

Beneficial effect of probiotics supplements in reflux esophagitis treated with esomeprazole: A randomized controlled trial. PMID31114137

Heart Failure

Hydrogen- and Methane-Based Breath Testing and Outcomes in Patients With Heart Failure. DOI: 10.1016/j.cardfail.2018.10.004
Impact of intestinal microbiota in patients with heart failure: A systematic review. DOI: 10.1016/j.medcle.2019.06.017

Inflammatory Bowel Disease

Gastrointestinal motility and absorptive disorders in patients with inflammatory bowel diseases: Prevalence, diagnosis and treatment. PMID: 31496621

Intestinal Failure: Pediatric

Serum Unconjugated Bile Acids and Small Bowel Bacterial Overgrowth in Pediatric Intestinal Failure: A Pilot Study. PMID: 30035316

Irritable Bowel Syndrome

Liver Disease

Small intestinal bacterial overgrowth and nonalcoholic fatty liver disease. PMID:30915401
An assessment of bacterial overgrowth and translocation in the non-alcoholic fatty liver of patients with morbid obesity. PMID: 30896956
The role of Small Intestinal Bacterial Overgrowth (SIBO) in Non-alcoholic Fatty Liver Disease (NAFLD) patients evaluated using Controlled Attenuation Parameter (CAP) Transient Elastography (TE): a tertiary referral center experience. PMID: 30894137
Alcoholic liver disease and mast cells: What's your gut got to do with it? https://doi.org/10.1016/j.livres.2019.02.002
Role of the intestinal microbiome in liver fibrosis development and new treatment strategies. DOI: 10.1016/j.trsl.2019.02.005
Gut microbial dysbiosis associates hepatocellular carcinoma via the gut-liver axis. DOI:10.1016/j.hbpd.2018.11.002
An assessment of bacterial overgrowth and translocation in the non-alcoholic fatty liver of patients with morbid obesity. PMID: 30896956
Su1083 – Small Intestinal Bacterial Overgrowth and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. DOI: 10.1016/S0016-5085(19)40180-7
Mo2015 – The Role of Small Intestinal Bacteria Overgrowth in Nonalcoholic Fatty Liver Disease. DOI: 10.1016/S0016-5085(19)39278-9
Is small intestinal bacterial overgrowth a cause of hyperdynamic circulation in cirrhosis? PMID: 31767551

Metabolic Syndrome

The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome. DOI: 10.1016/j.redox.2018.101091

Obesity (morbid)

An assessment of bacterial overgrowth and translocation in the non-alcoholic fatty liver of patients with morbid obesity. PMID: 30896956
Mo2023 – Association Between Obesity and Risk of Small Intestine Bacterial Overgrowth: A Systematic Review and Metaanalysis. DOI: 10.1016/S0016-5085(19)39287-X
Obesity and Risk of Small Intestine Bacterial Overgrowth: A Systematic Review and Meta-Analysis. PMID: 31605277
Effect of eradicating hydrogen-forming small intestinal bacterial overgrowth with rifaximin on body weight change. PMID: 31861004

Pancreatic Disease

Parkinson’s Disease

Gut reaction: impact of systemic diseases on gastrointestinal physiology and drug absorption. DOI: 10.1016/j.drudis.2018.11.009
Triggers, Facilitators, and Aggravators: Redefining Parkinson’s Disease Pathogenesis. DOI:10.1016/j.tins.2018.09.007
Contributions of Gut Bacteria and Diet to Drug Pharmacokinetics in the Treatment of Parkinson's Disease. PMID: 31681153
Bile acid abnormality induced by intestinal dysbiosis might explain lipid metabolism in Parkinson's disease. PMID: 31678900

Polyderma faciale NEW

Pyoderma faciale in a patient with small intestinal bacterial overgrowth. PMID: 30968945

Restless Legs Syndrome

Restless Leg Syndrome: Does It Start With A Gut Feeling? https://doi.org/10.1093/sleep/zsz067.008

Sexual Dysfunction NEW

Could problems in the bedroom come from our intestines? A preliminary study of IBS and its impact on female sexuality. PMID: 31488791

Short Bowel Syndrome

Surgery: Gastric By-pass/Bariatric

Systemic Sclerosis

Testing

Impact of Oral-Cecal Transit Time on the Interpretation of Lactulose Breath Tests After RYGB: a Personalized Approach to the Diagnosis of SIBO. PMID: 30627990
Serum Unconjugated Bile Acids and Small Bowel Bacterial Overgrowth in Pediatric Intestinal Failure: A Pilot Study. PMID: 30035316
Noninvasive Magnetogastrography Detects Erythromycin-Induced Effects on the Gastric Slow Wave. PMID: 29993499 (MMC testing)
BREATH TESTS FOR SMALL INTESTINAL BACTERIAL OVERGROWTH DIAGNOSIS: A SYSTEMATIC REVIEW WITH META-ANALYSIS. https://doi.org/10.1016/S1590-8658(19)30442-6
Second-Generation Biomarker Testing for Irritable Bowel Syndrome Using Plasma Anti-CdtB and Anti-Vinculin Levels. PMID: 31152332
Gastric, small bowel and colonic motility and breath-testing. DOI: 10.1016/j.mpmed.2019.03.006
First Large Scale Study Defining the Characteristic Microbiome Signatures of Small Intestinal Bacterial Overgrowth (SIBO): Detailed Analysis from the Reimagine Study. DOI: 10.1016/S0016-5085(19)36776
Su1949 – Small Intestinal Aspirates Require Specific Treatment to Optimize Microbial Analysis: Validation of a Novel Technique from the Reimagine Study DOI: https://doi.org/10.1016/S0016-5085(19)38583-X
Sa1912 – Revealing the Entire Intestinal Microbiota and Its Associations to the Genetic, Immunologic, and Neuroendocrine Ecosystems: Methodology for the Reimagine Study. DOI: https://doi.org/10.1016/S0016-5085(19)37978-8
P.06.12 BREATH TESTS FOR SMALL INTESTINAL BACTERIAL OVERGROWTH DIAGNOSIS: A SYSTEMATIC REVIEW WITH META-ANALYSIS. DOI: 10.1016/S1590-8658(19)30442-6
Tu1873 – Bowel Cleansing May Affect Diagnostic Yield of Small Bowel Aspirates for Diagnosis of Sibo in Patients with Diarrhea. DOI: 10.1016/S0016-5085(19)39856-7
Tu1600 – Air Or Carbon Dioxide Insufflation in Upper Endoscopies and the Yield of Quantitative Small Bowel Aspirate Cultures. DOI: 10.1016/S0016-5085(19)39605-2
Sa1953 – Pictograms are Highly Effective for Diagnosing Abdominal Bloating and Distension in Patients with Irritable Bowel Syndrome (IBS). DOI: 10.1016/S0016-5085(19)38019-9
Su1949 – Small Intestinal Aspirates Require Specific Treatment to Optimize Microbial Analysis: Validation of a Novel Technique from the Reimagine Study. DOI: 10.1016/S0016-5085(19)38583-X
Changes in Fecal Calprotectin After Rifaximin Treatment in Patients With Nonconstipated Irritable Bowel Syndrome. DOI: 10.1016/j.amjms.2018.11.004.
Reaction of antibodies to Campylobacter jejuni and cytolethal distending toxin B with tissues and food antigens. PMID: 30862994
Zonulin in serum as a biomarker fails to identify the IBS, functional dyspepsia and non-coeliac wheat sensitivity. PMID: 31563879
Characterization of Proximal Small Intestinal Microbiota in Patients With Suspected Small Intestinal Bacterial Overgrowth: A Cross-Sectional Study. PMID: 3146469
Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders. PMID: 31043597
Optimizing microbiome sequencing for small intestinal aspirates: validation of novel techniques through the REIMAGINE study. PMID: 31675917
Lactulose Breath Testing as a Predictor of Response to Rifaximin in Patients With Irritable Bowel Syndrome With Diarrhea. PMID: 31688023
Carbohydrate Intolerance and Disaccharidase Measurement - a Mini-Review. PMID: 31857738
Diagnostic Utility of Carbohydrate Breath Tests for SIBO, Fructose, and Lactose Intolerance. PMID: 31617133
Breath Test Gas Patterns in Inflammatory Bowel Disease with Concomitant Irritable Bowel Syndrome-Like Symptoms: A Controlled Large-Scale Database Linkage Analysis. PMID: 31754993
Duodenal and rectal mucosal microbiota related to small intestinal bacterial overgrowth in diarrhea-predominant irritable bowel syndrome. PMID: 31674052
Breath Tests for the Non-invasive Diagnosis of Small Intestinal Bacterial Overgrowth: A Systematic Review With Meta-analysis. PMID: 31743632

Methane

Tu1887 – Patients with Appendectomy Have Significantly Less Methane in Their Exhaled Breath: is the Appendix a Vestigial Organ Or an Important Reservoir for Methanogens? doi: 10.1016/S0016-5085(19)39870-1
Tu1897 – Enteric Methane Or Hydrogen Production in Patients with Unexplained Gastrointestinal Symptoms: Associations with Age, Symptoms and Proton Pump Inhibitors doi: 10.1016/S0016-5085(19)39880-4
Su1635 – Oral Iron Supplementation, Microbiome Related Methanogenesis and Constipation - a Novel Model to Explain and Age Old Problem doi: 10.1016/S0016-5085(19)38374-X

Hydrogen Sulfide

SIBO AS AN ADAPTATION: A PROPOSED ROLE FOR HYDROGEN SULFIDE NDNR
Sa1918 – Jejunal But Not Colonic Hydrogen Sulfide Increased Portal Blood Flow But Not Portal Pressure. DOI: 10.1016/S0016-5085(19)37984-3
Breath Test Gas Patterns in Inflammatory Bowel Disease with Concomitant Irritable Bowel Syndrome-Like Symptoms: A Controlled Large-Scale Database Linkage Analysis. PMID: 31754993

Treatment

Management of Small Intestinal Bacterial Overgrowth in Adult Patients. PMID: 31145251

Antibiotics

Effectiveness of Saccharomyces boulardii and Metronidazole for Small Intestinal Bacterial Overgrowth in Systemic Sclerosis. PMID: 31549334
Effect of Rifaximin Treatment on Endotoxemia and Insulin Sensitivity in Humans. PMID: 31428718
Changes in Fecal Calprotectin After Rifaximin Treatment in Patients With Nonconstipated Irritable Bowel Syndrome. DOI: 10.1016/j.amjms.2018.11.004.
Su1589 – Predictive Factors of Response to Rifaximin in Irritable Bowel Syndrome and Bacterial Overgrowth. DOI: 10.1016/S0016-5085(19)38328-3
444 – Rifaximin for Improving Abdominal Pain and Bloating Symptoms in Patients with Irritable Bowel Syndrome with Diarrhea (IBS-D) Using Modified Definitions of Pain Response. DOI: 10.1016/S0016-5085(19)37017-9
Mo1545 – Characterization of Abdominal Pain Response to Rifaximin in Patients with Irritable Bowel Syndrome with Diarrhea (IBSD), by Baseline Pain Severity
Lactulose Breath Testing as a Predictor of Response to Rifaximin in Patients With Irritable Bowel Syndrome With Diarrhea. PMID: 31688023

Bacteriophage NEW

Transplanting Fecal Virus-Like Particles Reduces High-Fat Diet-Induced Small Intestinal Bacterial Overgrowth in Mice. PMID: 31750259

Prokinetics

Rikkunshito Depolarizes Pacemaker Potentials of Cultured Interstitial Cells of Cajal through Ghrelin Receptors in Murine Small Intestine. PMID: 30889598
Prucalopride for the treatment of constipation: a view from 2015 and beyond. PMID:30791758
Prucalopride, A Recently Approved Drug by the Food and Drug Administration for Chronic Idiopathic Constipation. PMID: 30820411
The effect of pyridostigmine on small intestinal bacterial overgrowth(SIBO) and plasma inflammatory biomarkers in HIV-associated autonomic neuropathies. PMID: 31098925
Mo1584 – Effectiveness of Lanreotide in the Treatment of Patients with Small Bowel Motility Disorder (SBMD). DOI: 10.1016/S0016-5085(19)38928-0
In brief: Tegaserod (Zelnorm) returns. PMID: 31169806
Prucalopride (Motegrity) for chronic idiopathic constipation. PMID: 31170120
Clinical Efficacy and Safety Profile of Prucalopride in Chronic Idiopathic Constipation. PMID: 31218146
Study Design and Cohort Comparability in a Study of Major Cardiovascular Events in New Users of Prucalopride Versus Polyethylene Glycol 3350. PMID: 31134513
Cardiovascular Safety of Prucalopride in Patients with Chronic Constipation: A Multinational Population-Based Cohort Study. PMID: 31134512
Use of prucalopride in adults with chronic idiopathic constipation. PMID: 31096799

Probiotics

Acupuncture

Acupuncture protects the interstitial cells of Cajal by regulating miR-222 in a rat model of post-operative ileus. PMID: 30852906

Ameliorating Effects of Electroacupuncture on Dysmotility, Inflammation and Pain Mediated via the Autonomic Mechanism in a Rat Model of Postoperative Ileus. PMID: 30827069

Fecal Microbiota Transplantation (FMT)

Microbiota, Microbial Metabolites, and Barrier Function in A Patient with Anorexia Nervosa after Fecal Microbiota Transplantation. PMID: 31510101
Tu1878 – Fecal Microbiota Transplantation (FMT) in Irritable Bowel Syndrome (IBS): A Systematic Review and Meta-Analysis. DOI: 10.1016/S0016-5085(19)39861-

Diet

FODMAP Diet