2020 Research Articles

​Related

• Mapping the Segmental Microbiomes in the Human Small Bowel in Comparison with Stool: A REIMAGINE Study. PMID: 32140945
• Optimizing microbiome sequencing for small intestinal aspirates: validation of novel techniques through the REIMAGINE study. PMID: 31675917
• Sa1925 —THERE ARE MAJOR DIFFERENCES BETWEEN LUMINAL AND MUCOSAL BACTERIAL COMPOSITION IN THE SMALL BOWEL OF HUMANS. 

 
Overview

• ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth. PMID: 32023228
• Small Intestinal Bacterial Overgrowth. PMID: 31536241
• Chapter 24: Small intestinal bacterial and fungal overgrowth. DOI: 10.1016/B978-0-12-813037-7.00024-8
• Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome - An Update. PMID: 32754068
• AGA Clinical Practice Update on Small Intestinal Bacterial Overgrowth: Expert Review.  PMID: 32679220

 
Underlying Causes (pathophysiological)
    ICC (Interstitial Cells of Cajal)

• Association between interstitial cells of Cajal and anti-vinculin antibody in human stomach. PMID: 32140042

     Small Intestinal Motility 

• Chapter 22 - Small intestinal motility disorders. DOI: 10.1016/B978-0-12-813037-7.00022-4

 
Pathophysiology 

• ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth. PMID: 32023228
• The duodenal microbiome is altered in small intestinal bacterial overgrowth. PMID: 32645011
• Jejunum: The understudied meeting place of dietary lipids and the microbiota. PMID: 32949677
• The Structure and Function of the Human Small Intestinal Microbiota: Current Understanding and Future Directions. DOI: 10.1016/j.jcmgh.2019.07.006
• Maldigestion Versus Malabsorption in the Elderly.  PMID: 32500383
• Sa1708 SMALL INTESTINAL BACTERIAL OVERGROWTH IN REFRACTORY CONSTIPATION IS ASSOCIATED WITH DELAYED COLONIC TRANSIT, BUT NOT DYSSYNERGIC DEFECATION.  DOI: 10.1016/S0016-5085(20)31672-3
• Su1766 —DIFFERENCES IN CLINICAL PRESENTATION BETWEEN PATIENTS WITH AERODIGESTIVE TRACT SMALL INTESTINAL BACTERIAL OVERGROWTH (SIBO) AND COLIFORM SIBO
• Su1732 —OVERABUNDANCE OF HISTAMINE PRODUCING ENTEROBACTERIACEAE CONTRIBUTES TO GASTRIC PAIN IN PATIENTS WITH DIABETIC GASTROPARESIS

Causes/ Risk Factors
 
   Overview

• Risk Factors Associated With Upper Aerodigestive Tract or Coliform Bacterial Overgrowth of the Small Intestine in Symptomatic Patients. PMID: 30575635

    Antibiotics

• From IBS to ME – The dysbiotic march hypothesis. DOI: 10.1016/j.mehy.2020.109648   

   Chemotherapy

• The FOCCUS study: a prospective evaluation of the frequency, severity and treatable causes of gastrointestinal symptoms during and after chemotherapy. PMID: 32676853
• P-362 SIBO and lactose intolerance in patients receiving chemotherapy treatment for colorectal or gastric cancer. DOI: 10.1016/j.annonc.2020.04.444

   Diseases

• A proposed tailored investigational algorithm for women treated for gynaecological cancer with long-term gastrointestinal consequences. PMID: 31997018
• Small intestinal bacterial overgrowth and Celiac disease - coincidence or causation?  PMID: 32295433
• Su1743 —PREVALENCE AND SPECTRUM OF GI MOTILITY DISORDERS IN JOINT HYPERMOBILITY SYNDROME IN AN ACADEMIC REFERRAL CENTER
• Association between small intestinal bacterial overgrowth and beta-cell function of type 2 diabetes.  PMID: 32691685
• Advanced Pancreatic Ductal Adenocarcinoma: Moving Forward. DOI: 10.3390/cancers12071955. PMID: 32708493
• Is there an association between adult symptomatic intestinal malrotation and small intestinal bacterial overgrowth? PMID: 32674876
• A proposed tailored investigational algorithm for women treated for gynaecological cancer with long-term gastrointestinal consequences. PMID: 31997018
• Relation of endometriosis and neuromuscular disease of the gastrointestinal tract: new insights. PMID: 9660426
• Chronic diarrhoea in an oncology patient – Clinical assessment and decision making  doi.org/10.1016/j.bpg.2020.101708
• Radiation-induced damage in the upper gastrointestinal tract: clinical presentation, diagnostic tests and treatment options  doi.org/10.1016/j.bpg.2020.101711
• Cystic fibrosis: Physiopathology and the latest pharmacological treatments  doi.org/10.1016/j.phrs.2020.105267
• Nutritional status and predictors of weight loss in patients with systemic sclerosis  doi.org/10.1016/j.clnesp.2020.09.030

   Food/Water Poisoning

• Association between interstitial cells of Cajal and anti-vinculin antibody in human stomach. PMID: 32140042
• Microbiome and Its Role in Irritable Bowel Syndrome. PMID: 32026278
• Immunization with cytolethal distending toxin B produces autoantibodies to vinculin and small bowel bacterial changes in a rat model of postinfectious irritable bowel syndrome.  PMID: 32436301
• Mo1566 —ANTI-VINCULIN AND ANTI-CYTOLETHAL DISTENDING TOXIN B (CDTB) ANTIBODIES ARE LINKED DIRECTLY TO CHANGES IN THE MICROBIOME AND CYTOKINE EXPRESSION AS PART OF THE PATHOPHYSIOLOGY OF POST-INFECTIOUS IBS

    PPI's/Hypochlorhydria 

• The effects of proton pump inhibitors on the microbiome in young children. PMID: 32027402
• Study of Small Intestinal Bacterial Overgrowth in a Cohort of Patients with Abdominal Symptoms Who Underwent Bariatric Surgery. PMID: 32048154
• Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Case-Control Studies. PMID: 31913194
• Latest insights into the hot question of proton pump inhibitor safety – a narrative review.  DOI: 10.1016/j.dld.2020.04.020
• Su1202 QUANTITATIVE PCR AS A NOVEL APPROACH TO DETERMINE SMALL INTESTINAL BACTERIAL LOAD IN HEALTH AND DISEASE.  DOI: 10.1016/S0016-5085(20)32050-3
• Mo1792 EFFECTS OF SHORT-TERM PPI INTAKE ON PRODUCING SIBO AND BOWEL SYMPTOMS. A STUDY IN HEALTHY VOLUNTEERS.  DOI: 10.1016/S0016-5085(20)32992-9
• The effects of continuous proton pump inhibitor therapy on small intestinal bacterial overgrowth in elderly. PMID: 32838502
• The effects of proton pump inhibitors on the microbiome in young children. PMID: 32027402
• The Use and Misuse of Proton Pump Inhibitors: An Opportunity for Deprescribing.   PMID: 33321078
• [Proton Pump Inhibitors and their Microbiome-Mediated Side Effects].  PMID: 33327006

    Surgery 

• Diagnostic and Therapeutic Management of Post-Gastric Bypass Chronic Diarrhea: a Systematic Review. PMID: 31902043
• Study of Small Intestinal Bacterial Overgrowth in a Cohort of Patients with Abdominal Symptoms Who Underwent Bariatric Surgery. PMID: 32048154
• Systematic review: the effect of right hemicolectomy for cancer on postoperative bowel function.  PMID: 32430603
• Effects of Probiotics Supplementation on Gastrointestinal Symptoms and SIBO after Roux-en-Y Gastric Bypass: a Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. PMID: 32780258
• Measuring small intestinal bacterial overgrowth using the hydrogen breath test among postoperative patients with biliary atresia. PMID: 32950354
• Bariatric Surgery and Its Complications in Inflammatory Bowel Disease Patients. PMID: 31626698
• Changes to gastrointestinal function after surgery for colorectal cancer  doi.org/10.1016/j.bpg.2020.101705
• Small Intestinal Bacterial Overgrowth: Clinical Presentation in Patients with Roux-en-Y Gastric Bypass  PMID: 33047289
• Surgical Management of Small Intestinal Bacterial Overgrowth After Roux-en-Y Gastric Bypass.  PMID: 32594468

    Weight

• Role of Small Intestinal Bacterial Overgrowth (SIBO) and Inflammation in Obese Children. DOI: 10.3389/fped.2020.00369 PMID: 32733827

Associated Conditions

   General

• The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders.  PMID: 32429454

   Alzheimer’s

• Association of Intestinal Disorders with Parkinson's Disease and Alzheimer's Disease: A Systematic Review and Meta-Analysis. PMID: 31876406

   Anemia

• Predictors of Small Intestinal Bacterial Overgrowth in Symptomatic Patients Referred for Breath Testing.  PMID: 33029272

   Cancer

• Advanced Pancreatic Ductal Adenocarcinoma: Moving Forward. PMID: 32708493
• A proposed tailored investigational algorithm for women treated for gynaecological cancer with long-term gastrointestinal consequences. PMID: 31997018
• Chronic diarrhoea in an oncology patient – Clinical assessment and decision making  doi.org/10.1016/j.bpg.2020.101708
  • “In our late effects [oncology] clinic [SIBO] has been identified as a contributor for a variety of GI symptoms in 46% of patients and very commonly this includes chronic diarrhoea.”
• Radiation-induced damage in the upper gastrointestinal tract: clinical presentation, diagnostic tests and treatment options  doi.org/10.1016/j.bpg.2020.101711
• Changes to gastrointestinal function after surgery for colorectal cancer  doi.org/10.1016/j.bpg.2020.101705

   Celiac disease

• Small intestinal bacterial overgrowth and Celiac disease - coincidence or causation?  PMID: 32295433

• The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders.  PMID: 32429454

   Children (Pediatrics)

• THE IMPACT OF SMALL INTESTINAL BACTERIAL OVERGROWTH ON THE GROWTH OF CHILDREN AND ADOLESCENTS. PMID: 31939507
• The effects of proton pump inhibitors on the microbiome in young children. PMID: 32027402
• Factors Related to the Development of Small-Bowel Bacterial Overgrowth in Pediatric Intestinal Failure: A Retrospective Cohort Study. PMID: 32167608
• Tu1778 ROLE OF GLUCOSE BREATH TEST FOR SMALL INTESTINAL BACTERIAL OVERGROWTH IN CHILDREN WITH ABDOMINAL PAIN DISORDERS AND EFFICACY OF ANTIMICROBIAL TREATMENT.  DOI: 10.1016/S0016-5085(20)33566-6
• Role of Small Intestinal Bacterial Overgrowth (SIBO) and Inflammation in Obese Children. DOI: 10.3389/fped.2020.00369 PMID: 32733827
• The effects of proton pump inhibitors on the microbiome in young children. DOI: 10.1111/apa.15213 PMID: 32027402
• Enteral Nutrition in Pediatric Short-Bowel Syndrome. DOI: 10.1002/ncp.10565 PMID: 32815247

   Common Variable Immunodeficiency (CVID)

• Can concurrent lower gastrointestinal manifestations help the timely diagnosis of small intestinal bacterial overgrowth in CVID patients? PMID: 32186350

   Chronic Intestinal Pseudo Obstruction

• An international survey on clinicians' perspectives on the diagnosis and management of chronic intestinal pseudo-obstruction and enteric dysmotility. DOI: 10.1111/nmo.13937 PMID: 32696607

   Cystic Fibrosis

• Gastrointestinal complications of cystic fibrosis. DOI: 10.1016/j.paed.2020.07.002
• Choline in cystic fibrosis: relations to pancreas insufficiency, enterohepatic cycle, PEMT and intestinal microbiota.  PMID: 32797252
• Cystic fibrosis: Physiopathology and the latest pharmacological treatments  doi.org/10.1016/j.phrs.2020.105267

   Diabetes

• Association between small intestinal bacterial overgrowth and beta-cell function of type 2 diabetes. DOI: 10.1177/0300060520937866 PMID: 32691685

   Dyspepsia

• Gut Microbiota Dysbiosis in Functional Dyspepsia.  PMID: 32397332
• The Effect of Ursodeoxycholic Acid on Small Intestinal Bacterial Overgrowth in Patients with Functional Dyspepsia: A Pilot Randomized Controlled Trial.  PMID: 32422942
• High prevalence of small intestinal bacterial overgrowth among functional dyspepsia patients  PMID: 33011725

   Ehlers-Danlos Syndrome

• Su1743 —PREVALENCE AND SPECTRUM OF GI MOTILITY DISORDERS IN JOINT HYPERMOBILITY SYNDROME IN AN ACADEMIC REFERRAL CENTER
• An international survey on clinicians' perspectives on the diagnosis and management of chronic intestinal pseudo-obstruction and enteric dysmotility. PMID: 32696607

   Elderly

• Common Urinary and Bowel Disorders in the Geriatric Population. DOI: 10.1016/j.mcna.2020.06.009 PMID: 32773048

   Endometriosis

• Relation of endometriosis and neuromuscular disease of the gastrointestinal tract: new insights. PMID: 9660426

  Gallbladder Disease

• Measuring small intestinal bacterial overgrowth using the hydrogen breath test among postoperative patients with biliary atresia. PMID: 32950354

   Gastric Bypass

• Small Intestinal Bacterial Overgrowth: Clinical Presentation in Patients with Roux-en-Y Gastric Bypass  PMID: 33047289
• Surgical Management of Small Intestinal Bacterial Overgrowth After Roux-en-Y Gastric Bypass.  PMID: 32594468

   Gastroparesis

• Delayed Gastric Emptying Is Not Associated with a Microbiological Diagnosis of Small Intestinal Bacterial Overgrowth. PMID: 32124195

   GERD

• The effects of continuous proton pump inhibitor therapy on small intestinal bacterial overgrowth in elderly.  PMID: 32838502

   IBD

• Relationship between Small Intestinal Bacterial Overgrowth and Peripheral Blood ET, TLR2 and TLR4 in Ulcerative Colitis. PMID: 32169129
• The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders.  PMID: 32429454
• Bariatric Surgery and Its Complications in Inflammatory Bowel Disease Patients. DOI: 10.1093/ibd/izz246 PMID: 31626698
• Duodenal bacterial load as determined by quantitative polymerase chain reaction in asymptomatic controls, functional gastrointestinal disorders and inflammatory bowel disease. DOI: 10.1111/apt.15786 PMID: 32412673

   IBS / Post-Infectious IBS

• Microbiome and Its Role in Irritable Bowel Syndrome. PMID: 32026278
• ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth. PMID: 32023228
• Evidence of altered mucosa-associated and fecal microbiota composition in patients with Irritable Bowel Syndrome. PMID: 31953505
• Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Case-Control Studies. PMID: 31913194
• Mechanism of action and therapeutic benefit of rifaximin in patients with irritable bowel syndrome: a narrative review. PMID: 32047534
• Connaissez-vous le SIBO ? DOI: 10.1016/S1773-035X(20)30007-1
• The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders.  PMID: 32429454
• Short-course Rifaximin Therapy Efficacy and Lactulose Hydrogen Breath Test in Chinese Patients With Diarrhea-Predominant Irritable Bowel Syndrome.  PMID: 32532214
• A Meta-Analysis on Small Intestinal Bacterial Overgrowth in Patients With Different Subtypes of Irritable Bowel Syndrome.  PMID: 31750966
• Bacterial therapy for irritable bowel syndrome.  DOI: 10.1016/S2468-1253(20)30079-0
• Gut Microbial Dysbiosis in the Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Case-Control Studies.  DOI: 10.1016/j.jand.2019.05.015
• Mo1534 PREVALENCE OF METHANE POSITIVE SMALL INTESTINAL BACTERIAL OVERGROWTH IN IBS AND IBD: A SYSTEMATIC REVIEW AND METAANALYSIS.  DOI: 10.1016/S0016-5085(20)32900-0
• From IBS To ME – The Dysbiotic March Hypothesis.  DOI: 10.1016/j.mehy.2020.109648
• Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome - An Update.  PMID: 32754068
• Duodenal bacterial load as determined by quantitative polymerase chain reaction in asymptomatic controls, functional gastrointestinal disorders and inflammatory bowel disease.  PMID: 32412673  
• Molecular Mechanisms of Microbiota-Mediated Pathology in Irritable Bowel Syndrome.  PMID: 33212919
• The overlap between irritable bowel syndrome and organic gastrointestinal diseases  doi.org/10.1016/S2468-1253(20)30212-0
• Bidirectional association between irritable bowel syndrome and restless legs syndrome: a systematic review and meta-analysis  doi.org/10.1016/j.sleep.2020.12.002

   Impaired Spermatogenesis  NEW

• Small intestinal bacterial overgrowth (SIBO) as a potential cause of impaired spermatogenesis.  PMID: 32066624

   Large Intestine Dysbiosis  NEW

• Fecal bacteria can predict the efficacy of rifaximin in patients with diarrhea-predominant irritable bowel syndrome. PMID: 32470562

   Leaky Gut

• Intestinal permeability and small intestine bacterial overgrowth in excess weight adolescents  PMID: 33089672
• Leaky Gut and Gut-Liver Axis in Liver Cirrhosis: Clinical Studies Update.  PMID: 33071239

   Liver Disease

• Small Intestinal Bacterial Overgrowth Diagnosed by a Breath Test and Improved by Rifaximin in a Patient with Hepatic Encephalopathy and Alcoholic Liver Cirrhosis. PMID: 32321898
• Association of worsening of nonalcoholic fatty liver disease with cardiometabolic function and intestinal bacterial overgrowth: A cross-sectional study. PMID: 32845887
• Non-alcoholic Steatohepatitis: Comparison of Intestinal Microbiota between Different Metabolic Profiles. A Pilot Study.  PMID: 32830817
• Molecular Mechanism Contributing to Malnutrition and Sarcopenia in Patients with Liver Cirrhosis.  PMID: 32731496
• PERIPHERAL BLOOD ENDOTOXIN LEVELS ARE NOT ASSOCIATED WITH SMALL INTESTINAL BACTERIAL OVERGROWTH IN NONALCOHOLIC FATTY LIVER DISEASE WITHOUT CIRRHOSIS.  PMID: 33331479
• Active Vitamin D(3) Treatment Attenuated Bacterial Translocation via Improving Intestinal Barriers in Cirrhotic Rats.  PMID: 33258263
• Leaky Gut and Gut-Liver Axis in Liver Cirrhosis: Clinical Studies Update.  PMID: 33071239

   Malabsorption

• Maldigestion Versus Malabsorption in the Elderly.  PMID: 32500383
• Small intestinal bacterial overgrowth as a cause of protracted wound healing and vitamin D deficiency in a spinal cord injured patient with a sacral pressure sore: a case report. PMID: 32831031
• Choline in cystic fibrosis: relations to pancreas insufficiency, enterohepatic cycle, PEMT and intestinal microbiota. PMID: 32797252
• Jejunum: The understudied meeting place of dietary lipids and the microbiota. PMID: 32949677

    NASH/NAFLD

• Molecular Mechanisms: Connections between Nonalcoholic Fatty Liver Disease, Steatohepatitis and Hepatocellular Carcinoma. PMID: 32102237
• Small intestinal bacterial overgrowth and nonalcoholic fatty liver disease: a systematic review and meta-analysis.  PMID: 31567712
• The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders.  PMID: 32429454
• Small Intestinal Bacterial Overgrowth Diagnosed by a Breath Test and Improved by Rifaximin in a Patient with Hepatic Encephalopathy and Alcoholic Liver Cirrhosis: A Case Report.  PMID: 32321898

   Obesity

• The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders.  PMID: 32429454
• Role of Small Intestinal Bacterial Overgrowth (SIBO) and Inflammation in Obese Children.  PMID: 32733827
• Intestinal permeability and small intestine bacterial overgrowth in excess weight adolescents  PMID: 33089672

   Pancreatitis

• Association between increased breath hydrogen methane concentration and prevalence of glucose intolerance in acute pancreatitis. PMID: 31689699       

   Parkinson’s disease

• Bile acid abnormality induced by intestinal dysbiosis might explain lipid metabolism in Parkinson's disease. PMID: 31678900
• Association of Intestinal Disorders with Parkinson's Disease and Alzheimer's Disease: A Systematic Review and Meta-Analysis. PMID: 31876406
• The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders.  PMID: 32429454
• Targeting the microbiota in pharmacology of psychiatric disorders.  DOI: 10.1016/j.phrs.2020.104856
• Helicobacter pylori Eradication in Parkinson's Disease: A Randomized Placebo-Controlled Trial.  PMID: 32894625
• Effects of Helicobacter pylori on Levodopa Pharmacokinetics.  PMID: 33164946

   Pediatric Intestinal Failure

• Factors Related to the Development of Small-Bowel Bacterial Overgrowth in Pediatric Intestinal Failure: A Retrospective Cohort Study. PMID: 32167608

   Restless Legs Syndrome

• Bidirectional association between irritable bowel syndrome and restless legs syndrome: a systematic review and meta-analysis  doi.org/10.1016/j.sleep.2020.12.002

   Rosacea

• An altered fecal microbial profiling in rosacea patients compared to matched controls.  PMID: 32446756
• Rosacea and the gastrointestinal system. DOI: 10.1111/ajd.13401 PMID: 32761824
• Rosacea and the Microbiome: A Systematic Review.  PMID: 33170492

   Short Bowel Syndrome

• A comparison of small bowel and fecal microbiota in children with short bowel syndrome. PMID: 32063370
• Paradoxical Elevation of Both Serum B12 and Methylmalonic Acid Levels in Assessing B12 Status in Children With Short-Bowel Syndrome. PMID: 31985849
• Risk factors for renal dysfunction in adult patients with short bowel syndrome  doi.org/10.1016/j.clnesp.2020.09.062
• Antibiotic Stewardship Through Standardized Diagnosis and Treatment of Small Bowel Bacterial Overgrowth in Pediatric Patients With Short Bowel Syndrome Reduces Antibiotic Exposure and Improves Cost of Health Care.  PMID: 33334923

   Smoking  NEW

• Predictors of Small Intestinal Bacterial Overgrowth in Symptomatic Patients Referred for Breath Testing.  PMID: 33029272

   Systemic Sclerosis

• Effectiveness of Saccharomyces boulardii and Metronidazole for Small Intestinal Bacterial Overgrowth in Systemic Sclerosis. PMID: 31549334
• The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders.  PMID: 32429454
• The Role of Fecal Calprotectin in Patients with Systemic Sclerosis and Small Intestinal Bacterial Overgrowth (SIBO). DOI: 10.3390/diagnostics10080587 PMID: 32823752

Superior Mesenteric Artery Syndrome NEW

• Superior Mesenteric Artery Syndrome: A Potentially Fatal but Reversible Gastrointestinal Manifestation of Systemic Sclerosis. PMID: 32695548
• Revascularization of Isolated Superior Mesenteric Artery Dissection for Post Mesenteric Infarction Exudative enteropathy: The Contribution of a multidisciplinary Care Teamwork  doi.org/10.1016/j.avsg.2020.10.037

Testing

• [Influencing Factors on Lactulose Breath Test Results]. PMID: 31986570
• Breath Methane Does Not Correlate With Constipation Severity or Bloating in Patients With Constipation. PMID: 31306344
• ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth. PMID: 32023228

           Commentary: Defines SIBO as a clinical syndrome which includes both symptoms and a positive test.

• Evidence of altered mucosa-associated and fecal microbiota composition in patients with Irritable Bowel Syndrome. PMID: 31953505
• THE IMPACT OF SMALL INTESTINAL BACTERIAL OVERGROWTH ON THE GROWTH OF CHILDREN AND ADOLESCENTS. PMID: 31939507
• Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Case-Control Studies. PMID: 31913194
• Breath Tests for the Non-invasive Diagnosis of Small Intestinal Bacterial Overgrowth: A Systematic Review With Meta-analysis. PMID: 31743632
• Association between increased breath hydrogen methane concentration and prevalence of glucose intolerance in acute pancreatitis. PMID: 31689699
• Mo1789 A COMPARISON OF LACTULOSE BREATH TESTS TO DUODENAL ASPIRATES FOR THE DIAGNOSIS OF SMALL INTESTINAL BACTERIAL OVERGROWTH.  DOI: 10.1016/S0016-5085(20)32989-9 [appears on 10.1016/S0016-5085(20)32992-9]
• Mo1791 APPLICATION OF NORTH AMERICAN CONSENSUS CRITERIA TO A COMMERCIAL BREATH TEST FOR INTESTINAL BACTERIAL OVERGROWTH.  DOI: 10.1016/S0016-5085(20)32991-7 [appears on 10.1016/S0016-5085(20)32992-9]
• Small Intestinal Bacterial Overgrowth Diagnosed by a Breath Test and Improved by Rifaximin in a Patient with Hepatic Encephalopathy and Alcoholic Liver Cirrhosis: A Case Report.  PMID: 32321898
• The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders.  PMID: 32429454
• Short-course Rifaximin Therapy Efficacy and Lactulose Hydrogen Breath Test in Chinese Patients With Diarrhea-Predominant Irritable Bowel Syndrome.  PMID: 32532214
• A Meta-Analysis on Small Intestinal Bacterial Overgrowth in Patients With Different Subtypes of Irritable Bowel Syndrome.  PMID: 31750966
• Mo1534 PREVALENCE OF METHANE POSITIVE SMALL INTESTINAL BACTERIAL OVERGROWTH IN IBS AND IBD: A SYSTEMATIC REVIEW AND METAANALYSIS.  DOI: 10.1016/S0016-5085(20)32900-0
• Sa1732 PATTERN OF METHANE LEVELS WITH LACTULOSE BREATH TESTING; CAN WE SHORTEN TEST DURATION?  DOI: 10.1016/S0016-5085(20)31694-2
• Su1202 QUANTITATIVE PCR AS A NOVEL APPROACH TO DETERMINE SMALL INTESTINAL BACTERIAL LOAD IN HEALTH AND DISEASE.  DOI: 10.1016/S0016-5085(20)32050-3
• Mo1566 —ANTI-VINCULIN AND ANTI-CYTOLETHAL DISTENDING TOXIN B (CDTB) ANTIBODIES ARE LINKED DIRECTLY TO CHANGES IN THE MICROBIOME AND CYTOKINE EXPRESSION AS PART OF THE PATHOPHYSIOLOGY OF POST-INFECTIOUS IBS
• Mo1321 — 2020  AGA
  THE UTILITY OF GLUCOSE HYDROGEN BREATH TEST IN IRRITABLE BOWEL SYNDROME: A SYSTEMATIC REVIEW
• Su1761 —SMALL INTESTINAL BACTERIAL OVERGROWTH: IS IT TIME TO SHORTEN TESTING?
• Su1766 —DIFFERENCES IN CLINICAL PRESENTATION BETWEEN PATIENTS WITH AERODIGESTIVE TRACT SMALL INTESTINAL BACTERIAL OVERGROWTH (SIBO) AND COLIFORM SIBO
• Mo1790 —CLINICAL UTILITY AND DIAGNOSTIC YIELD OF DUODENAL VERSUS JEJUNAL ASPIRATES FOR SIBO OR SIFO
• Sa1912 —METHANOGEN ABUNDANCE THRESHOLDS DIFFERENTIATE METHANE AND NON-METHANE PRODUCERS
• Su1211 —THE FIRST STUDY TO DETERMINE THE NORMAL RANGE OF EXHALED HYDROGEN SULFIDE (H2S) USING A NOVEL 4-GAS BREATH TEST DEVICE IN HEALTHY SUBJECTS
• The duodenal microbiome is altered in small intestinal bacterial overgrowth. PMID: 32645011
• Early hydrogen excretion peaks during breath tests. Small intestinal bacterial overgrowth or accelerated transit? PMID: 32868214
• Diagnosing Small Intestinal Bacterial Overgrowth: A Comparison of Lactulose Breath Tests to Small Bowel Aspirates. PMID: 32681227
• Breath Test or Duodenal Aspirate for Small Intestinal Bacterial Overgrowth: Still No Breath of Fresh Air. PMID: 32816209
• The Role of Fecal Calprotectin in Patients with Systemic Sclerosis and Small Intestinal Bacterial Overgrowth (SIBO). PMID: 32823752
• Development of a Score to Predict Positive Colonic Histology in Chronic Diarrhea Assessed in Open-access Colonoscopy. PMID: 32833700
• Faecal calprotectin levels after rifaximin treatment in patients with irritable bowel syndrome with diarrhoea: A single-center prospective study.  PMID: 32928705
• Calprotectin, an available prognostic biomarker in systemic sclerosis: a systematic review  PMID: 33044726
• Small Intestinal Bacterial Overgrowth Syndrome: A Guide for the Appropriate Use of Breath Testing.  PMID: 33037967
• Hydrogen and methane breath test results are negatively associated with IBS and may reflect transit time in post-surgical patients.  PMID: 33184950
• pn-Heterojunction of the SWCNT/ZnO nanocomposite for temperature dependent reaction with hydrogen.  PMID: 33129166

Methane

• ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth. PMID: 32023228

          Commentary: Intestinal Methanogen Overgrowth (IMO) is proposed as a new name for Methane SIBO.

• Comparing the rates of methane production in patients with and without appendectomy: results from a large-scale cohort. PMID: 31964997
• Mo1534 PREVALENCE OF METHANE POSITIVE SMALL INTESTINAL BACTERIAL OVERGROWTH IN IBS AND IBD: A SYSTEMATIC REVIEW AND METAANALYSIS.  DOI: 10.1016/S0016-5085(20)32900-0
• Sa1708 SMALL INTESTINAL BACTERIAL OVERGROWTH IN REFRACTORY CONSTIPATION IS ASSOCIATED WITH DELAYED COLONIC TRANSIT, BUT NOT DYSSYNERGIC DEFECATION.  DOI: 10.1016/S0016-5085(20)31672-3
• Sa1732 PATTERN OF METHANE LEVELS WITH LACTULOSE BREATH TESTING; CAN WE SHORTEN TEST DURATION?  DOI: 10.1016/S0016-5085(20)31694-2
• Mo1786 ELEVATED BREATH METHANE ON LACTULOSE BREATH TEST FOR SIBO INDEPENDENTLY PREDICTS IMPROVED OUTCOME AT 1-YEAR FOLLOWUP: A LONGITUDINAL STUDY USING PATIENT REPORTED OUTCOMES MEASURES.  DOI: 10.1016/S0016-5085(20)32986-3
• Mo1547 —LHMBT POSITIVE IBS-D PATIENTS PRESENTED A BETTER RESPONSE ON RIFAXIMIN TREATMENT: A CLINICAL TRIAL BASED ON MICROTIOTICS
• Small Intestinal Bacterial Overgrowth: How to Diagnose and Treat (and Then Treat Again).  DOI: 10.1016/j.gtc.2020.04.010
• The Effect of Ursodeoxycholic Acid on Small Intestinal Bacterial Overgrowth in Patients with Functional Dyspepsia: A Pilot Randomized Controlled Trial.  PMID: 32422942
• Sa1912 —METHANOGEN ABUNDANCE THRESHOLDS DIFFERENTIATE METHANE AND NON-METHANE PRODUCERS

Hydrogen Sulfide

• ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth. PMID: 32023228
• Sa1215 —USING A NOVEL 4-GAS BREATH TEST DEVICE, MULTIVARIABLE ANALYSIS REVEALS AN ASSOCIATION BETWEEN EXCESSIVE HYDROGEN SULFIDE ON BREATH TESTING AND HEARTBURN
• Su1211 —THE FIRST STUDY TO DETERMINE THE NORMAL RANGE OF EXHALED HYDROGEN SULFIDE (H2S) USING A NOVEL 4-GAS BREATH TEST DEVICE IN HEALTHY SUBJECTS

 
Treatment 

• ACG Clinical Guideline: Management of Irritable Bowel Syndrome.  PMID: 33315591Small Intestinal Bacterial Overgrowth: How to Diagnose and Treat (and Then Treat Again).  DOI: 10.1016/j.gtc.2020.04.010
• The Effect of Ursodeoxycholic Acid on Small Intestinal Bacterial Overgrowth in Patients with Functional Dyspepsia: A Pilot Randomized Controlled Trial.  PMID: 32422942
• Ultraviolet A light effectively reduces bacteria and viruses including coronavirus.  PMID: 32673355

   Herbal Antibiotics

• Sa1908 —BERBERINE RESTORES MICROGLIA ACTIVATION INDUCED BY FECAL MICROBIOTA FROM IBS PATIENT IN GERM-FREE RATS WITH A DISTINCT EFFECT ON MICROBIOTA COMPARED WITH RIFAXIMIN
• Alternative Treatment Approaches to Small Intestinal Bacterial Overgrowth: A Systematic Review.  PMID: 33074705

   Antibiotics

• Study of Small Intestinal Bacterial Overgrowth in a Cohort of Patients with Abdominal Symptoms Who Underwent Bariatric Surgery. PMID: 32048154
• ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth. PMID: 32023228
• Effectiveness of Saccharomyces boulardii and Metronidazole for Small Intestinal Bacterial Overgrowth in Systemic Sclerosis. PMID: 31549334
• Mo1534 PREVALENCE OF METHANE POSITIVE SMALL INTESTINAL BACTERIAL OVERGROWTH IN IBS AND IBD: A SYSTEMATIC REVIEW AND METAANALYSIS.  DOI: 10.1016/S0016-5085(20)32900-0
• Mo1527 —ASSESSMENT OF REPONSE TO THERAPY IN SMALL INTESTINAL BACTERIAL OVERGROWTH (SIBO): AN ANALYSIS OF MULTIPLE VALIDATED PATIENT REPORTED OUTCOMES MEASURE INSTRUMENTS
• COLIGENTA treatment of small intestinal bacterial overgrowth. Results of an open study  PMID: 33229276

   Antibiotics: Rifaximin

• Use of Lactulose Breath Tests to Predict Response to Rifaximin in Irritable Bowel Syndrome With Diarrhea: The Positives and Negatives. PMID: 32118590
• Predicting Response to Rifaximin in Irritable Bowel Syndrome with Diarrhea: Is the Answer Blowing in the Wind? PMID: 32068023
• Current and emerging pharmacological approaches for treating diarrhea-predominant irritable bowel syndrome. PMID: 31738621
• Current US Food and Drug Administration-Approved Pharmacologic Therapies for the Treatment of Irritable Bowel Syndrome with Diarrhea. PMID: 31707713
• Efficacy of pharmacological therapies in patients with IBS with diarrhoea or mixed stool pattern: systematic review and network meta-analysis. PMID: 30996042
• ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth. PMID: 32023228
• Mechanism of action and therapeutic benefit of rifaximin in patients with irritable bowel syndrome: a narrative review. PMID: 32047534
• Small Intestinal Bacterial Overgrowth Diagnosed by a Breath Test and Improved by Rifaximin in a Patient with Hepatic Encephalopathy and Alcoholic Liver Cirrhosis: A Case Report.  PMID: 32321898
• Fecal bacteria can predict the efficacy of rifaximin in patients with diarrhea-predominant irritable bowel syndrome.  PMID: 32470562
• Mo1329 —RIFAXIMIN IS EFFICACIOUS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME WITH DIARRHEA (IBS-D) IN ADULTS PREVIOUSLY TREATED WITH OTHER IBS MEDICATIONS
• Short-course Rifaximin Therapy Efficacy and Lactulose Hydrogen Breath Test in Chinese Patients With Diarrhea-Predominant Irritable Bowel Syndrome.  PMID: 32532214
• Mo1544 IS SMALL INTESTINAL DYSBIOSIS (SIBO) RELATED TO IMPROVEMENT OF EPIGASTRIC PAIN, EARLY SATIETY AND POSTPRANDIAL PAIN IN RESPONSE TO ANTIMICROBIAL THERAPY WITH RIFAXIMIN IN PATIENTS WITH FUNCTIONAL GASTROINTESTINAL DISORDERS?  DOI: 10.1016/S0016-5085(20)32910-3
• Tu1778 ROLE OF GLUCOSE BREATH TEST FOR SMALL INTESTINAL BACTERIAL OVERGROWTH IN CHILDREN WITH ABDOMINAL PAIN DISORDERS AND EFFICACY OF ANTIMICROBIAL TREATMENT.  DOI: 10.1016/S0016-5085(20)33566-6
• Mo1547 —LHMBT POSITIVE IBS-D PATIENTS PRESENTED A BETTER RESPONSE ON RIFAXIMIN TREATMENT: A CLINICAL TRIAL BASED ON MICROTIOTICS
• Mo1338 —A POOLED ANALYSIS OF TWO PHASE 3, PLACEBO-CONTROLLED STUDIES ASSESSING THE IMPACT OF COLONOSCOPY TIMING ON RIAXIMIN EFFICACY IN IRRITABLE BOWEL SYNDROME WITH DIARRHEA (IBS-D)
• Sa1908 —BERBERINE RESTORES MICROGLIA ACTIVATION INDUCED BY FECAL MICROBIOTA FROM IBS PATIENT IN GERM-FREE RATS WITH A DISTINCT EFFECT ON MICROBIOTA COMPARED WITH RIFAXIMIN
• Adherence to Short-course Pharmacotherapy in Adults with Irritable Bowel Syndrome.  PMID: 31441709
• Increased Faecalibacterium abundance is associated with clinical improvement in patients receiving rifaximin treatment.  PMID: 32885687

   FMT (Fecal Microbiota Transplantation)

• Microbiome and Its Role in Irritable Bowel Syndrome. PMID: 32026278
• ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth. PMID: 32023228

   Prokinetics

• Prucalopride: Drugs and Lactation Database. PMID: 30694627
• Pharmacokinetics, Bioequivalence, and Safety Studies of Prucalopride in Healthy Chinese Subjects.  PMID: 31797570
• An international survey on clinicians' perspectives on the diagnosis and management of chronic intestinal pseudo-obstruction and enteric dysmotility. PMID: 32696607

   Probiotics

• ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth. PMID: 32023228
• Saccharomyces boulardii CNCM I-745: A Non-bacterial Microorganism Used as Probiotic Agent in Supporting Treatment of Selected Diseases.  PMID: 32472262
• Bacterial therapy for irritable bowel syndrome.  DOI: 10.1016/S2468-1253(20)30079-0
• Tu1931 — LACTOBACILLUS-CONTAINING PROBIOTICS ARE ASSOCIATED WITH CHANGES IN THE SMALL INTESTINAL MICROBIOME BUT NOT WITH SERUM INFLAMMATORY MARKERS: RESULTS FROM THE REIMAGINE STUDY
• Effects of Probiotics Supplementation on Gastrointestinal Symptoms and SIBO after Roux-en-Y Gastric Bypass: a Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. PMID: 32780258
• Alternative Treatment Approaches to Small Intestinal Bacterial Overgrowth: A Systematic Review.  PMID: 33074705

   Diet

• [The role of dietary diversity in the formation of syndrome intestinal bacterial overgrowth]. PMID: 32083825
• Evidence-based and mechanistic insights into exclusion diets for IBS. MID: 32123377
• Alternative Treatment Approaches to Small Intestinal Bacterial Overgrowth: A Systematic Review.  PMID: 33074705
• Food Additives, Gut Microbiota, and Irritable Bowel Syndrome: A Hidden Track.  PMID: 33260947
• Food and food products associated with food allergy and food intolerance - An overview.  Epub 2020 Oct 15. PMID: 33288166
• Dietary interventions and irritable bowel syndrome - what really works?  PMID: 33332914

   Diet: Gluten free

• Tu1910 — SUBJECTS ON A GLUTEN-FREE DIET HAVE SIGNIFICANT CHANGES IN THE SMALL BOWEL MICROBIOME ASSOCIATED WITH LOWER TNFα LEVELS: RESULTS FROM THE REIMAGINE STUDY

   Diet: Low FODMAP Diet

• Feasibility of Low Fermentable Oligosaccharide, Disaccharide, Monosaccharide, and Polyol Diet and Its Effects on Quality of Life in an Italian Cohort. PMID: 32182648
• Evidence-based and mechanistic insights into exclusion diets for IBS. PMID: 32123377
• The Low-FODMAP Diet Helps IBS Symptoms, but Questions Remain. PMID: 32101250
• Adherence to diet low in fermentable carbohydrates and traditional diet for irritable bowel syndrome. PMID: 32086111
• Low-FODMAP Diet for Irritable Bowel Syndrome: What We Know and What We Have Yet to Learn. PMID: 31986083
• Low FODMAP Diet: Evidence, Doubts, and Hopes. PMID: 31947991
• Effectiveness of Two Dietary Approaches on the Quality of Life and Gastrointestinal Symptoms of Individuals with Irritable Bowel Syndrome. PMID: 31906563
• The gut microbiome as a predictor of low fermentable oligosaccharides disaccharides monosaccharides and polyols diet efficacy in functional bowel disorders. PMID: 31850930
• Literature Review: Dietary Intervention Adherence and Adherence Barriers in Functional Gastrointestinal Disorder Studies. PMID: 31714332
• The long-term effect and adherence of a low fermentable oligosaccharides disaccharides monosaccharides and polyols (FODMAP) diet in patients with irritable bowel syndrome. PMID: 31637777
• Nutrient Intake, Diet Quality, and Diet Diversity in Irritable Bowel Syndrome and the Impact of the Low FODMAP Diet. PMID: 31029650
• Elimination of Fermentable Carbohydrates to Reduce Gastrointestinal Symptoms in Pediatric Patients With Irritable Bowel Syndrome: A Narrative Review. PMID: 30937981
• Microbiome and Its Role in Irritable Bowel Syndrome. PMID: 32026278
• ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth. PMID: 32023228
• Implementation of the low FODMAP diet in functional gastrointestinal symptoms: A real-world experience. PMID: 31571351
• Challenges of the low FODMAP diet for managing irritable bowel syndrome and approaches to their minimisation and mitigation.  PMID: 32468985
• Review Article: FODMAPS, Prebiotics and Gut Health. The FODMAP Hypothesis Revisited.  PMID: 32562590
• Low FODMAP diet significantly improves IBS symptoms: an Irish retrospective cohort study. DOI: 10.1007/s00394-019-02074-6 PMID: 31520160
• Low-FODMAP PMID: 32965895
• Review article: FODMAPS, prebiotics and gut health-the FODMAP hypothesis revisited. DOI: 10.1111/apt.15818 PMID: 32562590 Review.
• Is Bacillus coagulans supplementation plus low FODMAP diet superior to low FODMAP diet in irritable bowel syndrome management? DOI: 10.1007/s00394-019-02060-y PMID: 31327047
• A Low-FODMAP Diet for Irritable Bowel Syndrome: Some Answers to the Doubts from a Long-Term Follow-Up. DOI: 10.3390/nu12082360 PMID: 32784614
• Impaired cell surface expression and digestive function of sucrase-isomaltase gene variants are associated with reduced efficacy of low FODMAPs diet in patients with IBS-D. DOI: 10.1136/gutjnl-2019-319411 PMID: 31331993
• Feffect of Gluten Ingestion and Fodmap Restriction on Intestinal Epithelial Integrity in Patients with Irritable Bowel Syndrome and Self-reported Non-coeliac Gluten Sensitivity. DOI: 10.1002/mnfr.201901275 PMID: 32902928
• Does Fibre-fix provided to people with irritable bowel syndrome who are consuming a low FODMAP diet improve their gut health, gut microbiome, sleep and mental health? A double-blinded, randomised controlled trial. DOI: 10.1136/bmjgast-2020-000448 PMID: 32816830
• Food supplements and diet as treatment options in irritable bowel syndrome. DOI: 10.1111/nmo.13951 PMID: 32697018
• Characterization of the Extracellular Fructanase FruA in Lactobacillus crispatus and Its Contribution to Fructan Hydrolysis in Breadmaking. DOI: 10.1021/acs.jafc.0c02313 PMID: 32687341
• How fructophilic lactic acid bacteria may reduce the FODMAPs content in wheat-derived baked goods: a proof of concept. DOI: 10.1186/s12934-020-01438-6. PMID: 32943064
• Variability in yeast invertase activity determines the extent of fructan hydrolysis during wheat dough fermentation and final FODMAP levels in bread. DOI: 10.1016/j.ijfoodmicro.2020.108648 PMID: 32387971
• [Is the diet low in FODMAP really effective and safe for irritable bowel syndrome?: A scoping review]. PMID: 33153877
• Gut microbiota associations with diet in irritable bowel syndrome and the effect of low FODMAP diet and probiotics. PMID: 33183883
• Effects of Low and High FODMAP Diets on Human Gastrointestinal Microbiota Composition in Adults with Intestinal Diseases: A Systematic Review. PMID: 33114017
• Behavioral and Diet Therapies in Integrated Care for Patients With Irritable Bowel Syndrome. PMID: 33091411
• Management of Irritable Bowel Syndrome: Physician-Dietitian Collaboration. PMID: 32786046